RESUMO
The management of progressive unresectable low-grade glioma remains controversial. Treatment options have included radiotherapy, and more recently chemotherapy, usually following an initial period of observation. Within this context, we evaluated vinorelbine, a semi-synthetic vinca alkaloid that has shown evidence of activity against glioma. From July 2007 an institutional protocol with vinorelbine (30 mg/m(2) days 0, 8, 22) for a total of 18 cycles, has been conducted at IOP/GRAACC/UNIFESP for children with optic pathway glioma (OPG). The main objectives were clinical and radiological response, as well as toxicity profile. Twenty-three patients with progressive OPG with a mean age of 69 months (4-179) were enrolled. Three patients had a diagnosis of neurofibromatosis type 1. Twenty-two patients were assessable for response with an overall objective response rate of 63 %, with eight patients showing stable disease. The most important toxicity was hematologic (grade III/IV neutropenia) observed in four patients. Gastrointestinal toxicity (grade I/II vomiting) was observed in seven patients and only 1 patient showed grade I peripheral neuropathy. The median progression-free survival (PFS) was 33 months (6.9-69) with a 3 and 5 year PFS of 64 ± 19 and 37 ± 20 %, respectively, for an overall 3 and 5 year-survival of 95 ± 10 %. This study suggests that vinorelbine may be an interesting option for pediatric low-grade gliomas, showing low toxicity profile and providing a good quality of life for patients with such chronic disease.
Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Glioma do Nervo Óptico/tratamento farmacológico , Vimblastina/análogos & derivados , Adolescente , Antineoplásicos Fitogênicos/toxicidade , Encéfalo/efeitos dos fármacos , Encéfalo/patologia , Encéfalo/efeitos da radiação , Criança , Pré-Escolar , Progressão da Doença , Feminino , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Glioma do Nervo Óptico/patologia , Glioma do Nervo Óptico/fisiopatologia , Glioma do Nervo Óptico/radioterapia , Análise de Sobrevida , Resultado do Tratamento , Vimblastina/uso terapêutico , Vimblastina/toxicidade , VinorelbinaRESUMO
O objetivo deste artigo é relatar a experiência de implantação do modelo de prática avançada de enfermagem por meio da incorporação do enfermeiro clínico especialista na composição do quadro de enfermagem. As autoras apresentam o conceito desse modelo e descrevem seu processo de implantação em uma instituição de referência no cuidado à criança e ao adolescente com câncer da cidade de São Paulo, Brasil. Na avaliação das enfermeiras clínicas especialistas, o principal resultado obtido com a adoção do modelo refere-se ao fortalecimento do papel do enfermeiro como profissional de referência para a articulação das diferentes demandas de cuidado à criança, ao adolescente e ao adulto jovem com câncer e sua família. Também destacam a satisfação dos usuários com o estreitamento da relação paciente, família e enfermeira clínica, em todas as etapas do processo de cuidar.
El objetivo de este artículo es relatar la experiencia de implantación de un modelo de práctica avanzada en enfermería, por medio de la incorporación del enfermero clínico especialista en la composición del cuadro de personal de enfermería. Las autoras presentan el concepto de este modelo y describen el proceso de implantación en una institución de referencia para el cuidado de niños y adolescentes con cáncer de la ciudad de São Paulo, Brasil. Las enfermeras clínicas especialistas evalúan que el principal resultado de la adopción de este modelo fue el fortalecimiento del rol del enfermero como profesional de referencia para la articulación de las diferentes demandas de cuidado para la atención a los niños, adolescentes y adultos jóvenes con cáncer y su familia. También se destaca la satisfacción de los usuarios por el estrechamiento de la relación paciente, familia y enfermero clínico, en todas las etapas del proceso de cuidar.
The objective of this paper is to report the experience of implementing a model of advanced nursing practice that integrates a clinical nurse specialist into the nursing staff. The authors describe the concept of this model and the process of its implementation in a pediatric oncology reference institution in the city of São Paulo, Brazil. The main result achieved in evaluating the clinical nurse specialist was strengthening of the role of the nurse as a reference professional for the articulation of the various demands of care in assisting the child, adolescent or young adult with cancer and his/her family. The satisfaction of these users due to the closer relationship between the patient, family and clinical nurse in all stages of the caring process also stands out.
Assuntos
Modelos de Enfermagem , Enfermeiros Clínicos , Enfermagem Oncológica , Enfermagem Pediátrica , BrasilRESUMO
The objective of this paper is to report the experience of implementing a model of advanced nursing practice that integrates a clinical nurse specialist into the nursing staff. The authors describe the concept of this model and the process of its implementation in a pediatric oncology reference institution in the city of São Paulo, Brazil. The main result achieved in evaluating the clinical nurse specialist was strengthening of the role of the nurse as a reference professional for the articulation of the various demands of care in assisting the child, adolescent or young adult with cancer and his/her family. The satisfaction of these users due to the closer relationship between the patient, family and clinical nurse in all stages of the caring process also stands out.