[State of the liver in patients with obesity at distant periods after formation of a "small stomach"]. / Sostoianie pecheni u bol'nykh ozhireniem v otdalennye sroki posle operatsii formirovaniia "malogo zheludka".

Histological study of biopsy specimens taken from the liver of 96 patients during operation for formation of a "small stomach" revealed fatty dystrophy of the liver in 93 patients (96.9%) which was attended by marked inflammatory and fibrous changes in 68 (70.8%) of them and by disturbed lobar structure of the liver (cirrhosis) in 2 patients (2.1%). Biochemical blood tests failed to show the pattern of the pathological changes before the operation. Study of the hepatobiliary system with methionine-75Se was the only method by which protein and pigment metabolism in the liver could be appraised. Examination of patients during 3 postoperative years showed a positive dynamics of changes in biochemical blood tests and improved protein metabolism in the hepatocytes according to the results of scanning of the liver with methionine-75Se. Thirteen repeated studies of the hepatic tissue collected from patients in different periods after operation for the formation of a "small stomach" showed a significant diminution of fatty dystrophy and inflammation of the parenchyma. The level of portal tract inflammation and portal fibrosis did not change. The findings suggest that there is an improved functional and morphological condition of the liver in weight loss caused by operation for the formation of a "small stomach", which allows this type of surgical intervention to be recommended for the treatment of patients with alimentary-constitutional obesity and initially diminished compensatory capacities of the liver.

[Study of the hepatobiliary system using 75Se-methionine in chronic hepatitis in remission]. / Issledovanie gepatobiliarnoi sistemy s 75Se-metioninom pri khronicheskom gepatite v period remissii.

The investigation of 43 patients with diffuse liver diseases in remission has shown that the results of studies on the hepatobiliary system using 75Se-methionine possess the highest informative value. These results were compared with those of a biochemical blood analysis and echolocation. In the absence of evident deviations from the results of biochemical blood tests and suspected diseases of the liver and biliary tracts the authors recommended first an investigation with methionine, and then depending on results, the use of other methods.

[In vivo 75Se methionine metabolism in diseases of the hepatobiliary system]. / Issledovanie in vivo obmena 75Se metionina pri porazheniiakh gepatobiliarnoi sistemy.

A study of the hepatobiliary system with 75Se-methionine in 100 patients with different diffuse and focal diseases of the liver and biliary tract has shown that a study of the tissue metabolism of biologically active substances holds promise from the view-point of early diagnosis and rational therapy.

[The ventilation-perfusion process in the lungs following inhalation administration of 133Xe]. / Issledovanie ventiliatsionno-perfuzionnogo protsessa v legkikh pri ingaliatsionnom vvedenii 133Xe.

A study of the ventilation-perfusion process in 33 patients with various pulmonary diseases has shown the advantages of 133Xe administration by inhalation over i.v. administration. This method for the study of the ventilation-perfusion process in the lungs adequately reflects pathological changes in them; it is not traumatic, easy to perform and permits one to considerably lessen the radiation exposure of the patient and the staff.

[Study of different states of iodine metabolism in rats by means of whole-body radiometry]. / Izuchenie razlichnykh sostoianii iodnogo obmena u krys metodom radiometrii vsego tela

The authors present the principal concepts necessary for the use of the method of radiometry of the whole body in studying the iodine metabolism in vivo in the intact and thyroidectomized rats and also in experimental hyperthyroidism resulting from TTH or thyroidin administration. The iodine metabolism indices in euthyroidism and athyroidism in rats proved to be adequate to the corresponding curves of the iodine metabolism indices in healthy persons and those suffering from myxedema. Experimental hyperthyroidism in rats, similarly to hyperthyroidism in man, was characterized by an increase in tissue metabolism of the hormonal iodine. However, it was accompanied by an accelerated clearance of the organism from an excess of thyroid hormones; due to this it could not serve as an adequate model of thyrotoxicosis in man.

[The state of iodine metabolism in vegeto-vascular dystonia and neurasthenia]. / Sostoianie iodnogo obmena pri vegeto-sosudistoi distonii i nevrastenii

A method of radiometry of the whole body was applied to the study of iodine metabolism in 288 patients directed for examination with a preliminary diagnosis of thyrotoxicosis. The state of iodine metabolism was disturbed in half of them. In 9.1 per cent the changes corresponded to thyrotoxicosis, hypothyroidism. In the rest--disturbances followed the type of dissociation of iodine metabolism, i.e. only one of its phases altered, with a normal value of the rest. A total of 4 dissociation types were noted. The most frequent were the following: normal accumulation of iodine in the thyroid gland in combination with reduced level of organic iodine in the body and increased ioding content in the thyroid gland in combination with the normal organic iodine level in the body.