Assuntos
Miopia Degenerativa , Miopia , Descolamento Retiniano , Perfurações Retinianas , Retinosquise , Humanos , Miopia/diagnóstico , Miopia Degenerativa/diagnóstico , Miopia Degenerativa/cirurgia , Descolamento Retiniano/cirurgia , Perfurações Retinianas/cirurgia , Retinosquise/diagnóstico , Retinosquise/cirurgia , Óleos de Silicone , Tomografia de Coerência Óptica , VitrectomiaAssuntos
Corioide/irrigação sanguínea , Neovascularização de Coroide/diagnóstico , Miopia Degenerativa/diagnóstico , Varizes/diagnóstico , Angiofluoresceinografia , Humanos , Masculino , Pessoa de Meia-Idade , Esclera/irrigação sanguínea , Microscopia com Lâmpada de Fenda , Tomografia de Coerência Óptica , Acuidade Visual/fisiologiaRESUMO
The purpose of the study was to report a case of migration of a dexamethasone intravitreal implant (Ozurdex®) into anterior chamber and review the literature pertaining to the anterior chamber migration of implant. Clinical data were collected from a patient, in whom a dexamethasone intravitreal implant migrated to anterior chamber. A review of literature was conducted to analyze additional reports. A 59-year-old aphakic patient with recalcitrant cystoid macular edema due to chronic idiopathic uveitis was treated with intravitreal injection of dexamethasone implant. Migration of the implant into anterior chamber was noted after a month of injection. Since his cornea was clear and intraocular pressure was normal, he was managed conservatively. Sixteen such reports of migration of implant into anterior chamber was analyzed to look into the possible etiologies and outcome. Disruption of lens capsule, large basal iridectomy, and prior vitrectomy are the primary risk factors for migration of dexamethasone implant into the anterior chamber.
Assuntos
Artralgia/complicações , Febre/complicações , Lúpus Eritematoso Sistêmico/complicações , Mialgia/complicações , Retina/patologia , Doenças Retinianas/etiologia , Adolescente , Feminino , Angiofluoresceinografia/métodos , Fundo de Olho , Humanos , Doenças Retinianas/diagnóstico , Tomografia de Coerência Óptica/métodos , Acuidade VisualRESUMO
BACKGROUND: Choroidal metastases being the sole presenting feature of lung cancer is rare. Erlotinib, a tyrosine kinase inhibitor (TKI), is used in the treatment of lung adenocarcinoma where tumor cells exhibit epidermal growth factor receptor (EGFR) mutations. We report a case of metastatic non-small-cell lung cancer (NSCLC) with choroidal metastasis, which was the sole presenting feature and which responded to erlotinib. METHODS: We performed a retrospective case review. CASE: A 78-year-old man presented with a choroidal mass which was found to be the presenting feature of metastatic NSCLC. Our patient, a nonsmoker, had disseminated bony metastases, and therefore was advised to undergo palliative chemotherapy, which he refused. He was therefore instituted on oral erlotinib. RESULTS: Tumor cells expressing EGFR mutations are known to be susceptible to TKIs. Even though the tumor in our case showed no mutation, i.e. was classified as 'wild-type', our patient showed a dramatic response to erlotinib. At 1 year, the choroidal lesion had regressed and visual acuity had recovered. CONCLUSIONS: TKIs may be beneficial in patients with choroidal metastases from NSCLC, especially those in which an EGFR mutation is noted. Even in the absence of such mutations, choroidal metastases may show a favorable effect in response to TKIs, such as erlotinib.
RESUMO
Vincristine is used in the treatment of leukemias, solid tumors, and lymphomas. A case of a 2-year-old boy undergoing treatment for leukemia who developed sudden onset bilateral ptosis and ophthalmoplegia along with generalized neuropathy due to vincristine's neurotoxic effects is presented. He was successfully treated with pyridoxine and pyridostigmine. The possible mechanisms of action and the treatment for vincristine-induced neuropathy are discussed. Prompt treatment and close follow-up is needed, especially in children because prolonged ptosis and motility restriction may have a profound effect on a child's visual function.