[Hematocele and hemoperitoneum as initial manifestation of hepatocellular carcinoma. Report of one case]. / Hematocele y hemoperitoneo como manifestación inicial de carcinoma hepatocelular: Caso clínico.

Hepatocellular carcinoma (HCC) rupture is a rare complication, with a higher prevalence in countries of Asia and Europe. Its clinical manifestations can be nonspecific, from abdominal pain and bloating to hemodynamic involvement. We report a 70-year-old male patient with a history of chronic liver disease, presenting with an enlargement and ecchymosis of the scrotum, associated with abdominal bloating. The initial abdominal ultrasound study showed increased liquid content in the scrotal sac and regional edema. A CT of the abdomen and pelvis showed a liver mass with characteristics of hepatocellular carcinoma, associated with extensive hemoperitoneum that drained into the scrotal sac. The patient was treated with embolization of the right hepatic artery and later with surgical resection of the tumor mass, with a good clinical evolution.

Hematocele y hemoperitoneo como manifestación inicial de carcinoma hepatocelular: caso clínico / Hematocele and hemoperitoneum as initial manifestation of hepatocellular carcinoma: report of one case

Hepatocellular carcinoma (HCC) rupture is a rare complication, with a higher prevalence in countries of Asia and Europe. Its clinical manifestations can be nonspecific, from abdominal pain and bloating to hemodynamic involvement. We report a 70-year-old male patient with a history of chronic liver disease, presenting with an enlargement and ecchymosis of the scrotum, associated with abdominal bloating. The initial abdominal ultrasound study showed increased liquid content in the scrotal sac and regional edema. A CT of the abdomen and pelvis showed a liver mass with characteristics of hepatocellular carcinoma, associated with extensive hemoperitoneum that drained into the scrotal sac. The patient was treated with embolization of the right hepatic artery and later with surgical resection of the tumor mass, with a good clinical evolution.

Corrigendum to "In Vitro Determination of Genotoxicity Induced by Brackets Alloys in Cultures of Human Gingival Fibroblasts".

[This corrects the article DOI: 10.1155/2020/1467456.].

In Vitro Determination of Genotoxicity Induced by Brackets Alloys in Cultures of Human Gingival Fibroblasts.

Orthodontic brackets release ions that can be reabsorbed in the oral mucosa, potentially causing complications, including cytotoxic effects and mutagenic alterations. The aim was to evaluate the genotoxicity induced by orthodontic appliance alloys in cultures of human gingival fibroblasts by comet assay. Eluates were obtained from the following brackets alloys: EconoLine (SS: stainless steel), MiniMirage (Ni-Ti: nickel-titanium), Nu-Edge (Co-Cr: cobalt-chromium), In-Vu (PC-polycrystals (PC) aluminum oxide), and Monocrystal IZE (monocrystalline (MC) aluminum oxide). Each bracket was sterilized and exposed to a corrosive process for 35 days. The obtained eluates were tested for genotoxicity of human gingival fibroblasts (HGFA) by the alkaline comet assay. All study groups showed genotoxic effects; there was a significant difference (p < 0.0001) among groups. The eluates obtained from Ni-Ti showed a 16-times greater genotoxic effect. There were differences in genotoxicity after comparing the Ni-Ti with SS (p < 0.01) and Co-Cr brackets (p < 0.001). The ceramic was more genotoxic than metallic brackets (SS and Co-Cr), but less than the Ni-Ti. This in vitro model will be useful for further study of early DNA damage caused by brackets and other biomaterials used in the oral cavity before their introduction into the clinical setting.

Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review.

The purpose of this statement is to debate the recommendations of the American Heart Association (AHA) for the prevention of infective endocarditis through an antibiotic prophylaxis protocol and its relation with bacterial resistance to antibiotics. Since dental infections involve biofilms that include several bacterial species (Gram-negative and Gram-positive), it is essential, from the dental point of view, to consider the frequency, magnitude, and duration of bacteremia associated with active dental infections before applying antibiotic prophylaxis. The actual guidelines for antibiotic prophylaxis should be revised according to recent evidence of bacterial resistance. Amoxicillin/clavulanic acid and moxifloxacin should be considered due to their effectiveness against bacteria associated with oral, GU, and GI infections and the low rates of antibiotic resistance associated with these antibiotics, instead of the actual protocol, which includes amoxicillin (2 g) or clindamycin (600 mg) administered an hour before the dental procedures. The breaking point to test the antibiotic bacterial resistance (ABR) had a wide range in the different studies that were analyzed, which could explain the widely varied ABR percentages reported for the various antibiotics used for antibiotic prophylaxis.

Antimicrobial activity of endodontic sealers and medications containing chitosan and silver nanoparticles against Enterococcus faecalis.

BACKGROUND: The main microorganism associated with the failure of endodontic treatments is Enterococcus faecalis. Although several endodontic therapeutics have demonstrated antimicrobial activity against E. faecalis, the antimicrobial effectiveness of chitosan (CsNPs) and silver nanoparticles (AgNPs) included into conventional endodontic sealers for endodontic therapies is still unclear. AIM: The objective of this study was to evaluate the antibacterial activity increment (AAI) of endodontic sealers containing CsNPs and AgNPs as well as some chemical components against E. faecalis by direct contact assays. METHODS: CsNPs and AgNPs were synthesized by reduction and ionic gelation methods, respectively. Nanoparticles were characterized by dynamic light scattering and energy dispersive X-ray analysis. The bactericidal activity was tested on monolayers on agar plates and collagen membrane surface assays against E. faecalis. RESULTS: The size of CsNPs was 70.6±14.8 nm and zeta potential was 52.0±5.4 mV; the size of AgNPs was 54.2±8.5 nm, and zeta potential was -48.4±6.9 mV. All materials, single or combined, showed an AAI, especially when CsNPs, chlorhexidine (Chx), and the combination of CsNPs-Chx were added. However, the combination of CsNPs-Chx showed the highest (55%) AAI, followed by Chx (35.5%) and CsNPs (11.1%), respectively. There was a significant statistical difference in all comparisons (p < 0.05). Tubliseal (40%) and AH Plus (32%) sealants showed a higher AAI on E. faecalis in the monolayer test and collagen membrane assay analyzed by scanning electron microscopy. CONCLUSIONS: Tubliseal and AH plus sealers combined with nanoparticles, especially CsNPs-Chx, could be used for conventional endodontic treatments in the control of E. faecalis bacteria.

Influencia de los vasoconstrictores añadidos a la anestesia dental en la frecuencia cardiaca y la tensión arterial / Influence of vasoconstrictors added to dental anesthetics on blood pressure and heart rate

Introduction: vasoconstrictors are substances added to local anesthetics to lengthen their time of action, reduce their toxicity and enhance their local hemostatic effect. There is controversy about whether the use of vasoconstrictors in dental anesthetics has a negative effect on blood pressure and heart rate. Objective: determine the influence of vasoconstrictors added to dental anesthetics on blood pressure and heart rate. Methods: an experimental study was conducted with 120 patients divided in two groups of 60. These patients attended clinics in the Dental Academic Unit of the Autonomous University of Guerrero from July to December 2015. Group A was given just 3 percent mepivacaine, whereas Group B was given mepivacaine with epinephrine at a concentration of 1:100 000. Measurements were taken of the patients' heart rate, systolic blood pressure and diastolic blood pressure at two moments: at baseline before infiltration and 5 minutes after infiltration. Statistical analysis was based on Student's t-test for independent samples. Results: heart rate and systolic blood pressure did not yield any statistically significant value. Diastolic blood pressure was the only hemodynamic parameter showing a statistically significant difference (t= 2.3; p= 0.02). Conclusions: the results obtained coincide with those reported by similar studies. At the doses recommended, epinephrine is safe for healthy patients as well as for those with controlled cardiovascular conditions(AU)

Introducción: los vasoconstrictores son substancias que han sido añadidas a los anestésicos locales con la finalidad de aumentar su tiempo de acción, disminuir su toxicidad y aprovechar su efecto hemostático local. Existe controversia sobre si el uso de vasoconstrictores en los anestésicos dentales produce efectos negativos en la tensión arterial y la frecuencia cardiaca. Objetivo: determinar la influencia de los vasoconstrictores añadidos a la anestesia dental en la frecuencia cardiaca y la tensión arterial. Métodos: se realizó un estudio experimental en 120 pacientes divididos en dos grupos de 60, que acudieron a las clínicas de la Unidad Académica de Odontología de la Universidad Autónoma de Guerrero en el periodo julio-diciembre de 2015. Al grupo A se le administró mepivacaína simple al 3 por ciento, y al grupo B se le administró mepivacaína con epinefrina a una concentración de 1:100 000. Se realizaron tomas de frecuencia cardiaca, tensión arterial sistólica y tensión arterial diastólica en dos momentos. Se realizó una toma basal de frecuencia cardiaca, tensión arterial sistólica y diastólica antes de la infiltración, y una segunda toma 5 min posteriores a la infiltración. Se realizó la prueba estadística t de Student para grupos independientes. Resultados: la frecuencia cardiaca y la tensión arterial sistólica no obtuvieron significancia estadística. El único parámetro hemodinámico que tuvo una diferencia estadísticamente significativa fue la tensión arterial diastólica (t= 2,3; p= 0,02). Conclusiones : los resultados obtenidos en esta investigación, coinciden con los reportados en otros estudios similares. La epinefrina puede ser utilizada de manera segura a las dosis recomendadas tanto en pacientes sin enfermedad cardiovascular, como en pacientes con compromiso cardiovascular en control(AU)

Influencia de los vasoconstrictores añadidos a la anestesia dental en la frecuencia cardiaca y la tensión arterial / Influence of vasoconstrictors added to dental anesthetics on blood pressure and heart rate

Introduction: vasoconstrictors are substances added to local anesthetics to lengthen their time of action, reduce their toxicity and enhance their local hemostatic effect. There is controversy about whether the use of vasoconstrictors in dental anesthetics has a negative effect on blood pressure and heart rate. Objective: determine the influence of vasoconstrictors added to dental anesthetics on blood pressure and heart rate. Methods: an experimental study was conducted with 120 patients divided in two groups of 60. These patients attended clinics in the Dental Academic Unit of the Autonomous University of Guerrero from July to December 2015. Group A was given just 3 percent mepivacaine, whereas Group B was given mepivacaine with epinephrine at a concentration of 1:100 000. Measurements were taken of the patients' heart rate, systolic blood pressure and diastolic blood pressure at two moments: at baseline before infiltration and 5 minutes after infiltration. Statistical analysis was based on Student's t-test for independent samples. Results: heart rate and systolic blood pressure did not yield any statistically significant value. Diastolic blood pressure was the only hemodynamic parameter showing a statistically significant difference (t= 2.3; p= 0.02). Conclusions: the results obtained coincide with those reported by similar studies. At the doses recommended, epinephrine is safe for healthy patients as well as for those with controlled cardiovascular conditions(AU)

Introducción: los vasoconstrictores son substancias que han sido añadidas a los anestésicos locales con la finalidad de aumentar su tiempo de acción, disminuir su toxicidad y aprovechar su efecto hemostático local. Existe controversia sobre si el uso de vasoconstrictores en los anestésicos dentales produce efectos negativos en la tensión arterial y la frecuencia cardiaca. Objetivo: determinar la influencia de los vasoconstrictores añadidos a la anestesia dental en la frecuencia cardiaca y la tensión arterial. Métodos: se realizó un estudio experimental en 120 pacientes divididos en dos grupos de 60, que acudieron a las clínicas de la Unidad Académica de Odontología de la Universidad Autónoma de Guerrero en el periodo julio-diciembre de 2015. Al grupo A se le administró mepivacaína simple al 3 por ciento, y al grupo B se le administró mepivacaína con epinefrina a una concentración de 1:100 000. Se realizaron tomas de frecuencia cardiaca, tensión arterial sistólica y tensión arterial diastólica en dos momentos. Se realizó una toma basal de frecuencia cardiaca, tensión arterial sistólica y diastólica antes de la infiltración, y una segunda toma 5 min posteriores a la infiltración. Se realizó la prueba estadística t de Student para grupos independientes. Resultados: la frecuencia cardiaca y la tensión arterial sistólica no obtuvieron significancia estadística. El único parámetro hemodinámico que tuvo una diferencia estadísticamente significativa fue la tensión arterial diastólica (t= 2,3; p= 0,02). Conclusiones : los resultados obtenidos en esta investigación, coinciden con los reportados en otros estudios similares. La epinefrina puede ser utilizada de manera segura a las dosis recomendadas tanto en pacientes sin enfermedad cardiovascular, como en pacientes con compromiso cardiovascular en control(AU)

Evaluación de la filtración corono-apical en la obturación endodóntica cuando se utilizan diferentes métodos de barrera

Este estudio contempla el análisis y comparación del sellado intracoronal en 50 órganos dentarios unirradiculares humanos extraídos, a los que se les realizó tratamiento endodóntico; posteriormente se dividieron en 5 grupos, de 10 cada uno, aplicando en 4 de los grupos los materiales utilizados como método barrera: Cavit G, Ketac Molar, Perma Seal, Single Bond y 1 grupo aparte de control que fue conformado sin ningún tipo de material de barrera. Luego fueron sumergidos en saliva artificial durante 1 mes; transcurrido este tiempo fueron teñidos con azul de metileno al 2% y se procedió a realizar los cortes para su estudio, evaluando la filtración corono apical en 7 secciones de 1mm cada una en toda la longitud radicular, inmediatamente después del material utilizado como método de barrera. Resultados: Se encontró que el adhesivo Single Bond fue el más eficaz como material barrera y que evitó la filtración corono apical.

This study analizes and compares the intracoronal sealing of 50 extracted, single rooted, human dental organs that underwent endodontic treatment; they were divided in 5 groups of 10 each, applying the materials used as barrier method: Cavit G, Ketac Molar, Perma Seal, Single Bond and to 4 groups and leaving one control group without any barrier material. Afterwards they were submerged in artificial saliva for 1 month; after this time they were stained with methylene blue at 2% and proceeded to make the cuts for their study, evaluating crown-apical filtration in 7 sections of 1 mm each along the entire root length starting immediately after the material used as a barrier method. Results: found that the adhesive Single Bond was the most effective as material barrier to avoid crown-apical filtration

Sustentabilidad en los servicios de salud bucal en México

La problemática de salud bucal en México se expresa como un verdadero mosaico epidemiológico, donde la satisfacción de las necesidades de salud bucal de la población está determinada por el cumplimiento de factores sociales como el acceso equitativo a los servicios de salud bucal. El enfoque del Desarrollo Humano Sustentable constituye la construcción de entornos en los cuales se manifieste la libertad de poder desplegar las capacidades u oportunidades y las más preciadas aspiraciones de los seres humanos; con esta visión se considera el análisis los factores del DHS que beneficiarán el transitar a un mayor desarrollo en las sociedades latinoamericanas.

The problem of oral health in Mexico is expressed as a true epidemiological mosaic where the satisfaction of the oral health needs of the population is determined by the fulfillment of social factors such as equitable access to oral health services. The approach of Sustainable Human Development constitutes the construction of environments in which the freedom to deploy the capabilities or opportunities and the most precious aspirations of human beings is manifested; With this vision, the analysis will consider the factors of the DHS that will benefit to move to a greater development in the Latin American societies.

Determining similarity of scientific entities in annotation datasets.

Linked Open Data initiatives have made available a diversity of scientific collections where scientists have annotated entities in the datasets with controlled vocabulary terms from ontologies. Annotations encode scientific knowledge, which is captured in annotation datasets. Determining relatedness between annotated entities becomes a building block for pattern mining, e.g. identifying drug-drug relationships may depend on the similarity of the targets that interact with each drug. A diversity of similarity measures has been proposed in the literature to compute relatedness between a pair of entities. Each measure exploits some knowledge including the name, function, relationships with other entities, taxonomic neighborhood and semantic knowledge. We propose a novel general-purpose annotation similarity measure called 'AnnSim' that measures the relatedness between two entities based on the similarity of their annotations. We model AnnSim as a 1-1 maximum weight bipartite match and exploit properties of existing solvers to provide an efficient solution. We empirically study the performance of AnnSim on real-world datasets of drugs and disease associations from clinical trials and relationships between drugs and (genomic) targets. Using baselines that include a variety of measures, we identify where AnnSim can provide a deeper understanding of the semantics underlying the relatedness of a pair of entities or where it could lead to predicting new links or identifying potential novel patterns. Although AnnSim does not exploit knowledge or properties of a particular domain, its performance compares well with a variety of state-of-the-art domain-specific measures. Database URL: http://www.yeastgenome.org/

Caries dental y los determinantes sociales de la salud en México / Dental caries and social determinants of health in Mexico

La caries dental es una enfermedad multifactorial que representa un problema de salud pública global y nacional. Se conocen los factores de riesgo individual, no así los asociados con su ocurrencia poblacional; no es claro por qué algunos países o regiones presentan mayor prevalencia que otros. Es necesario analizar los determinantes sociales de la salud (DSS) asociados. El objetivo de este estudio fue explorar la asociación entre algunos determinantes poblacionales y la prevalencia de caries dental en la población infantil mexicana. Se realizó un estudio de casos de carácter ecológico cuyas unidades de observación fueron las 32 entidades federativas de la República mexicana. Se realizó un análisis comparativo cualitativo (Qualitative Comparative Analysis, QCA por sus siglas en inglés) usando datos de la Encuesta Nacional de Caries Dental 2001, e información oficial sobre desigualdad en el ingreso (G), producto interno bruto (P), porcentaje de población analfabeta (A), porcentaje de población rural (R), porcentaje de población indígena (I), tasa migratoria neta (L), distribución indicada de sal yodada fluorada (F) por estado. Las configuraciones más frecuentes fueron GpARIlF (17,86 por ciento de los estados); gPariLF (14,29 por ciento); GpARIlf (10,71 por ciento) y gPariLf (7,14 por ciento). Al realizar la reducción a un Benchmark de 0,80, se obtuvo una consistencia de 0,900 y una cobertura de 0,463 con diez configuraciones. A un Benchmark de 0,90 se obtuvo una consistencia de 0,974 y una cobertura de 0,223 con cuatro configuraciones. La desigualdad en el ingreso participa consistentemente en los modelos causales de prevalencia de caries, la distribución de sal yodada y fluorada participa pero negativamente, indicando su presencia como factor protector ante la enfermedad. Se sugiere apoyar acciones que disminuyan la desigualdad en el ingreso, así como el continuar con la política de distribución de sal yodada y fluorada(AU)

Dental caries is a multifactorial disease which represents a public health problem globally and nationally. There are known individual risk factors, not the population associated with its occurrence; it is not clear why some countries or regions have higher prevalence than others. It is necessary to analyze the Social Determinants of Health (SDH) associated. The aim of this study was to explore the association between some population determinants and the prevalence of dental caries in Mexican children. A case study of ecological character whose observation units were the 32 states of Mexico was conducted. A qualitative comparative analysis was conducted, using data from 2001National Survey of Dental Caries, and official data on income inequality (G), gross domestic product (P), percentage of illiterate population (A), percentage of rural population (R), percentage of indigenous population (I), net migration rate (L), indicated distribution of iodized salt fluoridated by state(F). The most common settings were GpARIlF (17.86 percent of the states); gPariLF (14.29 percent); GpARIlf (10.71 percent) and gPariLf (7.14 percent). When reducing a 0.80Benchmark, 0.900 and consistency and 0.463 of coverage were obtained with ten settings. A 0.90 Benchmark, 0.974 of consistency and 0.223 of coverage were obtained with four settings. The income inequality consistently participates in causal models of caries prevalence; distribution of iodized and fluoridated salt was negatively involved indicating its presence as a protective factor against the disease. It is suggested supporting actions to reduce income inequality, as well as to continue the distribution policy of fluoridated and iodized salt(AU)

Use of the light absorption coefficient to monitor elemental carbon and PM2.5--example of Santiago de Chile.

The optical absorption coefficient, particulate matter with an aerodynamic diameter <2.5 microm, and elemental carbon (EC) have been measured simultaneously during winter and spring of 2000 in the western part of Santiago, Chile (Pudahuel district). The optical measurements were carried out with a low-cost instrument recently developed at the University of Santiago. From the data, a site-specific mass absorption coefficient of 4.45+/-0.01 m2/g has been found for EC. In addition, a mass absorption coefficient of 1.02+/-0.03 m2/g has been obtained for PM2.5. These coefficients can be used during the colder months (May-August) to obtain EC concentration or PM2.5 from a measurement of the light absorption coefficient (sigmaa). The high correlation that has been found between these variables indicates that sigmaa is a good indicator of the degree of contamination of urbanized areas. The data also show an increase in PM2.5 and EC concentration during winter and an increase in the ratio of EC to PM2.5. When the EC/PM2.5 ratio is calculated during rush hour (7:00 a.m.-11:00 a.m.) and during part of the night (9:00 p.m.-2:00 a.m.), it is found that the increase is caused by higher concentration levels of EC at night. These results suggest that the rise in the EC concentration is caused by emissions from heating and air mass transport of pollution from other parts of the city, while traffic contribution remains approximately constant.