RESUMO
Nanostructuration and 2D patterning of thin films are common strategies to fabricate biomimetic surfaces and components for microfluidic, microelectronic or photonic applications. This work presents the fundamentals of a surface nanotechnology procedure for laterally tailoring the nanostructure and crystalline structure of thin films that are plasma deposited onto acoustically excited piezoelectric substrates. Using magnetron sputtering as plasma technique and TiO2 as case example, it is demonstrated that the deposited films depict a sub-millimetre 2D pattern that, characterized by large lateral differences in nanostructure, density (up to 50%), thickness, and physical properties between porous and dense zones, reproduces the wave features distribution of the generated acoustic waves (AW). Simulation modelling of the AW propagation and deposition experiments carried out without plasma and under alternative experimental conditions reveal that patterning is not driven by the collision of ad-species with mechanically excited lattice atoms of the substrate, but emerges from their interaction with plasma sheath ions locally accelerated by the AW-induced electrical polarization field developed at the substrate surface and growing film. The possibilities of the AW activation as a general approach for the tailored control of nanostructure, pattern size, and properties of thin films are demonstrated through the systematic variation of deposition conditions and the adjustment of AW operating parameters.
Assuntos
Nanoestruturas , Condutividade Elétrica , Eletricidade , Nanotecnologia , SomRESUMO
The scientific interest in the growth of nanostructured surfaces and thin films by means of physical vapor deposition (PVD) techniques has undoubtedly increased in the last decade [...].
RESUMO
Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (DePuy Synthes) and a pseudo-rectangular bone plate extracted from a patient were coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments were performed: Analysis of bacterial adhesion and biofilm formation, and osteoblasts-bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior toward osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.
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El exantema fijo medicamentoso es una toxicodermia caracterizada por la aparición de una lesión cutánea en forma de mácula de color rojizo o violáceo, redonda u oval, edematosa, bien delimitada, y que presenta recurrencias tras la administración del agente causal, generalmente un fármaco. Puede ser producido por una gran variedad de fármacos, entre ellos el paracetamol. El paracetamol es un medicamento con propiedades analgésicas y antipiréticas ampliamente conocido y utilizado por su amplio margen de seguridad y elevada biodisponibilidad. Sin embargo, se han descrito reacciones cutáneas adversas de diferentes tipos e intensidad tras su administración, fundamentalmente urticaria y angioedema, y con menor frecuencia eritema multiforme, necrólisis epidérmica tóxica, exantema fijo y púrpura de Henoch-Schönlein. Se presenta el caso de un usuario tipo con exantema fijo medicamentoso relacionado con el consumo de paracetamol. Se ha realizado una revisión bibliográfica sobre los diversos hallazgos clínicos y el diagnóstico diferencial entre las diferentes toxicodermias, así como el manejo y abordaje de las lesiones basado en el concepto TIME
Fixed drug eruption is a toxicodermia characterized by the appearance of a well-circumscribed reddish or violet, circular or oval, edematous skin lesion which can present recurrences after taking the causal agent, usually a drug. It can be produced by a wide variety of drugs, including acetaminophen. Acetaminophen is a drug with analgesic and antipyretic properties widely known and used for its wide range of safety and high bio-availability. However, different types and intensity of adverse skin reactions have been reported following administration, mainly urticaria and angioedema, and less frequently erythema multiforme, toxic epidermal necrolysis, fixed exanthema and Henoch-Schönlein purpura. We present the case of a role model user with fixed drug exanthema after acetaminophen consumption. A bibliographic review has been made on the various clinical findings and the differential diagnosis between different toxicodermias, as well as the management and approach of the lesions based on the TIME concept
Assuntos
Humanos , Feminino , Idoso , Exantema/induzido quimicamente , Exantema/complicações , Acetaminofen/uso terapêutico , Traumatismos da Perna/induzido quimicamente , Traumatismos da Perna/complicações , Nitrofurazona/uso terapêutico , Vesícula/induzido quimicamente , Acetaminofen/efeitos adversos , Traumatismos da Perna/terapia , Vesícula/terapiaRESUMO
Objetivo: Evaluar la efectividad en términos de cicatrización de un copolímero acrílico con un grupo amino modificado para el tratamiento de heridas cutáneas de diferente etiología en el ámbito de la atención primaria de salud. Metodología: Se llevó a cabo un estudio prospectivo observacional, abierto, de medidas repetidas en una cohorte de pacientes que presentaban heridas cutáneas de diferente etiología. Se realizó un seguimiento de 4 semanas o hasta la cicatrización. Se estableció un procedimiento de curas cada 3 días, y contempló: limpieza, aplicación del producto de evaluación, cobertura con un tul graso, aplicación de gasa hidrófila y fijación con adhesivo de tejido no tejido. Resultados: Se incluyeron 16 lesiones y hubo tres pérdidas, por lo que se obtuvo una muestra final de 13 lesiones (5 lesiones por quemaduras de grado II, 3 lesiones traumáticas y 5 lesiones de evolución crónica). El 35,7% eran mujeres y la edad media de los pacientes era de 64,71 ± 19,37 (DE) años. De las 13 lesiones, 11 cicatrizaron en menos de 4 semanas, con una tasa de cicatrización del 99,4%, y 2 lesiones cicatrizaron a los 32 días. El tiempo medio hasta la cicatrización fue de 16 ± 22,03 (DE) días. Conclusiones: A pesar de disponer de una muestra muy reducida y lesiones heterogéneas por la etiología, los resultados han mostrado una elevada tasa de cicatrización y un buen comportamiento en el manejo del dolor
Objective: To evaluate the effectiveness an acrylic copolymer with a modified amino group, in wound healing of diverse aetiology skin lesions in Primary Healthcare setting. Methods: We performed a prospective, observational, open study with repeated measures on a cohort of patients with skin lesions of different aetiology. We monitored them for 4 weeks or until the wounds healed. The dressing procedure was performed every 3 days, and involved wound cleaning, application of the evaluation product, coverage with a tulle grass dressing, application of hydrophilic gauze and fixation with a non-woven adhesive bandage. Results: Of the 16 lesions initially included, 3 were lost during the study, leaving a final sample of 13 lesions (5 second-degree burns, 3 traumatic lesions, 5 chronic lesions). 35.7% of the sample were women, and the mean age of the patients was 64.71 ± 19.37 years. 11 out of 14 lesions healed within 4 weeks, with a total wound-healing rate of 99.4%, and 2 lesions healed at day 32. The mean healing time was 16 ± 22.03 days. Conclusions: Despite the small sample size and wound heterogeneity, the results have shown a high healing rate and a good behavior in pain management
Assuntos
Humanos , Polímeros/uso terapêutico , Ferimentos Penetrantes/terapia , Técnicas de Fechamento de Ferimentos , Úlcera Cutânea/terapia , Bandagens , Estudos Prospectivos , Atenção Primária à Saúde , Resultado do Tratamento , Materiais Biocompatíveis/análiseRESUMO
The fabrication of black-gold coatings using sputtering is reported here. Glancing angle deposition with a rotating substrate is needed to obtain vertical nanostructures. Enhanced light absorption is obtained in the samples prepared in the ballistic regime with high tilt angles. Under these conditions the diameter distribution of the nanostructures is centered at about 60 nm and the standard deviation is large enough to obtain black-metal behavior in the visible range.
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Bacterial colonization and biofilm formation on orthopedic implants is one of the worst scenarios in orthopedic surgery, in terms of both patient prognosis and healthcare costs. Tailoring the surfaces of implants at the nanoscale to actively promote bone bonding while avoiding bacterial colonization represents an interesting challenge to achieving better clinical outcomes. Herein, a Ti6Al4V alloy of medical grade has been coated with Ti nanostructures employing the glancing angle deposition technique by magnetron sputtering. The resulting surfaces have a high density of nanocolumnar structures, which exhibit strongly impaired bacterial adhesion that inhibits biofilm formation, while osteoblasts exhibit good cell response with similar behavior to the initial substrates. These results are discussed on the basis of a "lotus leaf effect" induced by the surface nanostructures and the different sizes and biological characteristics of osteoblasts and Staphylococcus aureus.
Assuntos
Materiais Revestidos Biocompatíveis/farmacologia , Nanoestruturas/química , Osteoblastos/citologia , Staphylococcus aureus/citologia , Ligas , Aderência Bacteriana/efeitos dos fármacos , Adesão Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Humanos , Microscopia de Força Atômica , Microscopia Confocal , Nanoestruturas/ultraestrutura , Osteoblastos/efeitos dos fármacos , Osteoblastos/ultraestrutura , Espectroscopia de Infravermelho com Transformada de Fourier , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/crescimento & desenvolvimento , Staphylococcus aureus/ultraestrutura , Titânio/farmacologia , Difração de Raios XRESUMO
El origen de las enfermedades metabólicas como ladiabetes mellitus (DM) representa la mayor epidemiaque se ha conocido hasta ahora. El pie diabético esun síndrome que engloba las alteraciones anatómicasy / o funcionales que ocurren en las extremidadesinferiores de las personas con diabetes, y presentanuna elevada morbilidad. El riesgo de una persona condiabetes a desarrollar a lo largo de su vida una úlceraen el pie es más del 25% y un 70% de las amputacionesde las extremidades inferiores se asocian con estaenfermedad. La clave para el enfoque del pie diabéticoes abordar el problema desde su etiopatogenia. Mediantela exploración de los pies se detectan muchasalteraciones secundarias de la neuropatía. Conociendolos elementos que intervienen en la patogénesis de laslesiones y las úlceras localizadas en el pie diabéticose clasifican como: neuropáticas, isquémicas y mixtas(neuroisquémicas) estás corresponden al 80% de lasúlceras en pacientes con DM. El tratamiento localTIME de las lesiones del pie requiere un enfoqueglobal, que nos permita eliminar los obstáculos parala curación y la aplicación de medidas que faciliten elcierre de las heridas crónicas mediante la aplicaciónde nuevos productos y materiales basados en la curaen ambiente húmedo. La aplicación de factores decrecimiento y otros productos que realizan funcionessimilares como es el caso de los apósitos de hialuronatode zinc (AHZn) son una alternativa terapéutica degran valor en lesiones tan complejas como las del piediabético. El AHZn está implicado en funciones comola vascularización, la morfogénesis, la reparación y laintegridad general de la matriz extracelular(AU)
The origin of metabolic diseases such as diabetes mellitus(DM) poses the biggest epidemic that has beenknown until now. The diabetic foot is a syndromethat encompasses the anatomical abnormalities and/ or functional occurring at the feet of people withdiabetes with high morbidity. The risk of a person withdiabetes to develop throughout their lives an ulcer inthe foot is over 25% and the 70% of leg amputationsare associated with this disease. The key to the approachof the diabetic foot is to approach the problemfrom a etiopatogenics. Through the exploration ofthe foot are detected many disturbances as a resultof neuropathy. Knowing that they are neuropathyand peripheral vascular disease. The componentsinvolved in the pathogenesis of the lesions and ulcersare classified as: neuropathy, ischemic and mixed (ischemicneuropathy) is implicated in 80% of ulcers inpatients with DM. The local treatment TIME of footinjuries requiring a global approach, which helps usto remove obstacles to healing and to implement measuresto facilitate closure of chronic wounds throughthe application of new products and materials basedon the principles of cure in wet environment. Theapplication of growth factors and other products thatsimilar functions such as hyaluronate Zinc dressing(AHZn), is an alternative therapies are of great valuein such complex lesions such as diabetic foot. TheAHZn is involved in functions such as vascularization,cellular morphogenesis, repair and overall integrityof the extra cellular matrix(AU)
Assuntos
Humanos , Pé Diabético/terapia , Ácido Hialurônico/uso terapêutico , Equipe de Assistência ao Paciente/tendências , Zinco/uso terapêutico , Anti-Infecciosos Locais/uso terapêutico , Matriz ExtracelularRESUMO
The ADDERMIS protective cream has these properties: it prevents skin maceration, exercises a regenerative effect, has bacteriostatic and bactericide activity, possesses a noted anti-inflammatory effect and reduces the risk of mycotic infections. Its application is indicated for use in cases of: skin lesions, such as bed sores or leg ulcers, which require the use of a barrier product; dermatitis lesions in zones of skin folds or due to diaper use; to prevent friction zones; fragile skin; peeling, zones where cracks in the skin appear...and to use for cases of incontinence when diapers are required.
Assuntos
Antibacterianos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Dermatopatias/prevenção & controle , Idoso , Envelhecimento/fisiologia , Humanos , Dermatopatias/etiologia , Dermatopatias/fisiopatologia , Incontinência Urinária/complicaçõesRESUMO
The authors made an observational study to evaluate the efficiency of Jaloplast (hyaluronic acid AH) as treatment for skin injuries having different etiologies. The authors highlight its results regarding cicatrisation (69%) and the improvement of lesions (15.38%). Moreover 80% of lesions have cicatrized in a time less than 11 weeks, without showing any adverse effects nor secondary effects. From these observations, the authors deduce the importance of this molecule formed by glucosamine glycane (hyalyuronate) at the organic level in general and specifically in the process of cicatrisation.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Ácido Hialurônico/uso terapêutico , Pele/lesões , Humanos , Ferimentos e Lesões/tratamento farmacológicoRESUMO
La crema protectora ADDERMIS presenta las siguientes propiedades: evita la maceración cutánea, ejerce un efecto regenerador, tiene actividad bacterioestática y bactericida, posee un destacado efecto antiinflamatorio y reduce el riesgo de infecciones micóticas. Se indica su aplicación en caso de: lesiones cutáneas que necesiten la utilización de un producto barrera (úlceras por presión, úlceras de pierna); lesiones por dermatitis (zona de pliegues cutáneos, del pañal); prevención en zonas de fricción; pieles frágiles, descamativas, zonas de grietas ; utilización de dispositivos de incontinencia (pañal)
The ADDERMIS protective cream has these properties: it prevents skin maceration, exercises a regenerative effect, has bacteriostatic and bactericide activity; possesses a noted anti-inflammatory effect and reduces the risk of mycotic infections. Its application is indicated for use in cases of: skin lesions, such as bed sores or leg ulcers, which require the use of a barrier product; dermatitis lesions in zones of skin folds or due to diaper use; to prevent friction zones; fragile skin; peeling; zones where cracks in the skin appear...and to use for cases of incontinence when diapers are required
Assuntos
Idoso , Humanos , Antibacterianos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Dermatopatias/prevenção & controle , Envelhecimento/fisiologia , Dermatopatias/etiologia , Dermatopatias/fisiopatologia , Incontinência Urinária/complicaçõesRESUMO
Estudio observacional para evaluar la eficacia de Jaloplast® (ácido hialurónico -AH-) en el tratamiento de heridas cutáneas de diferente etiología. Destacan sus resultados en cuanto a la cicatrización (69%) y mejora de las lesiones (15,38%). Además, un 80% de las lesiones ha cicatrizado en un tiempo inferior a las 11 semanas, sin presentar reacciones adversas o efectos secundarios. De todo ello se deduce la importancia de esta molécula de la familia de los glucosaminoglicanos (hialuronato) a nivel orgánico en general y específicamente en el proceso de cicatrización
The authors made an observational study to evaluate the efficiency of Jaloplast (hyaluronic acid AH) as treatment for skin injuries having different etiologies. The authors highlight its results regarding cicatrisation (69%) and the improvement of lesions (15.38%). Moreover 80% of lesions have cicatrized in a time less than 11 weeks, without showing any adverse effects nor secondary effects. From these observations, the authors deduce the importance of this molecule formed by glucosamine glycane (hyalyuronate) at the organic level in general and specifically in the process of cicatrisation