Effects of dynamic and rigid implantation on biomechanical characteristics of different sagittal alignment lumbar after single- or double-level spinal fixations: a finite-element modeling study.

BACKGROUND: Although it is critical to understand the accelerated degeneration of adjacent segments after fusion, the biomechanical properties of the spine have not been thoroughly studied after various fusion techniques. This study investigates whether four Roussouly's sagittal alignment morphotypes have different biomechanical characteristics after different single- or double-level spinal fixations. METHODS: The parametric finite element (FE) models of Roussouly's type (1-4) were developed based on the radiological data of 625 Chinese community population. The four Roussouly's type models were reassembled into four fusion models: single-level L4-5 Coflex fixation model, single-level L4-5 Fusion (pedicle screw fixation) model, double-level Coflex (L4-5) + Fusion (L5-S1) model, and double-level Fusion (L4-5) + Fusion (L4-5) model. A pure moment of 7.5 Nm was applied to simulate the physiological activities of flexion, extension, lateral bending and axial rotation. RESULTS: Both single-level and double-level spinal fixation had the greatest effect on lumbar range of motion, disc pressure, and annulus fibrosis stress in flexion, followed by lateral bending, extension, and axial rotation. In all models, the upper adjacent segment was the most influenced by the implantation and bore the most compensation from the fixed segment. For Type 2 lumbar, the L4-L5 Coflex effectively reduced the disc pressure and annulus fibrosis stress in adjacent segments compared to the L4-L5 Fusion. Similarly, the L4-L5 Coflex offered considerable advantages in preserving the biomechanical properties of adjacent segments for Type 1 lumbar. For Type 4 lumbar, the L4-L5 Coflex did not have superiority over the L4-L5 Fusion, resulting in a greater increase in range of motion at adjacent segments in flexion and extension. The difference between the two fixations was not apparent in Type 3 lumbar. Compared to the single-level Fusion, the changes in motion and mechanics of the lumbar increased after both the double-level Coflex + Fusion and Fusion + Fusion fixations, while the differences between two double-level fixation methods on adjacent segments of the four lumbar models were similar to that of the single-level fixation. CONCLUSION: Type 3 and Type 4 lumbar have good compensatory ability and therefore allow for a wider range of surgical options, whereas surgical options for small lordotic Type 1 and Type 2 lumbar are more limited and severe.

Construction and Validation of a Nomogram Clinical Prediction Model for Predicting Osteoporosis in an Asymptomatic Elderly Population in Beijing.

BACKGROUND: Based on the high prevalence and occult-onset of osteoporosis, the development of novel early screening tools was imminent. Therefore, this study attempted to construct a nomogram clinical prediction model for predicting osteoporosis. METHODS: Asymptomatic elderly residents in the training (n = 438) and validation groups (n = 146) were recruited. BMD examinations were performed and clinical data were collected for the participants. Logistic regression analyses were performed. A logistic nomogram clinical prediction model and an online dynamic nomogram clinical prediction model were constructed. The nomogram model was validated by means of ROC curves, calibration curves, DCA curves, and clinical impact curves. RESULTS: The nomogram clinical prediction model constructed based on gender, education level, and body weight was well generalized and had moderate predictive value (AUC > 0.7), better calibration, and better clinical benefit. An online dynamic nomogram was constructed. CONCLUSIONS: The nomogram clinical prediction model was easy to generalize, and could help family physicians and primary community healthcare institutions to better screen for osteoporosis in the general elderly population and achieve early detection and diagnosis of the disease.

Morphology of paraspinal muscles in frail and non-frail older adults evaluated through FRAIL scale.

BACKGROUND: Frailty is a condition characterized by the progressive deterioration of physiological functioning, which is closely related to adverse events. Multiple previous investigations applied frailty scales for spine research, and the purpose of this study is to investigate the differences in the morphology of the paraspinal muscles in frail and non-frail older adults evaluated through FRAIL scale. METHODS: The sample of this retrospectively cross-sectional study consisted of individuals who were ≥ 60 years of age and with lumbar degenerative disease. We divided patients into two groups (0-2 = non-Frail, 3-5 = Frail) according to the FRAIL scale. The cross-sectional area (CSA) and percentage of the fatty infiltration (FI%) of the paraspinal muscles were compared between the two groups. RESULTS: The fCSA (functional cross-sectional area) of the non-Frail group (32.78 [28.52, 38.28]) (cm2) was significantly greater than that of the Frail group (28.50 [24.11, 34.77]) (p < 0.001). The ES FI% (erector spinae fatty infiltration rate) (24.83 ± 6.61 vs. 29.60 ± 7.92, p < 0.001) and MF FI% (multifidus fatty infiltration rate) (31.68 ± 5.63 vs. 41.12 ± 7.04, p < 0.001) of the non-Frail group were significantly lower than that of Frail group. CONCLUSIONS: The paraspinal muscles of elderly Frail patients screened by the FRAIL scale are worse than those of the non-Frail patients, and the ability of the FRAIL scale to distinguish paraspinal muscle morphology has important clinical significance.

A Comprehensive Analysis of the Behavior of Pelvic Incidence After Different Posterior Spinal Procedures in Elderly Patients With Spinal Deformity.

STUDY DESIGN: A retrospective case-control study. OBJECTIVE: To evaluate the behavior of pelvic incidence (PI) after different posterior spinal procedures in elderly patients with adult spinal deformity (ASD), to determine the potential associated factors with the variability in PI after spinal surgery and to comprehensively analyze its mechanisms. METHODS: Elderly patients underwent long fusion to sacrum with and without pelvic fixation were assigned to Group L+P and Group L-P, respectively. In Group L-P, those with severe sagittal deformity were selected as Group A. 20 elderly patients with severe sagittal deformity underwent short lumbar fusion were included as Group B. The following radiographic parameters were evaluated: thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), lumbar lordosis (LL), PI-LL, sagittal vertical axis (SVA), T1 pelvic angle (TPA), and pelvic parameters. PI changing more than 5° (△PI > 5°) was considered as substantially changed. RESULTS: For the whole cohort and in Group L+P, PI were not substantially changed (△PI ≤ 5°) after surgery. Besides the severer sagittal malalignment in patients with △PI > 5° in Group L-P, relatively larger mean age, greater proportion of female and lower preoperative PI were found than those in patients with △PI ≤ 5°. 70.8% of patients had substantial increase of PI in Group A, while only 10% of patients had in Group B (P < 0.001). CONCLUSION: PI behaves differently under different conditions in elderly ASD patients. Besides severe sagittal deformity, aging, female and low preoperative PI are also the potential risk factors of PI increasing after long fusion to sacrum.

Biomechanical comparative analysis of effects of dynamic and rigid fusion on lumbar motion with different sagittal parameters: An in vitro study.

Background: Although the management of the lumbar disease is highly dependent on the severity of the patient's condition, optimal surgical techniques to reduce the risk of adjacent degeneration disease (ADS) remain elusive. Based on in vitro biomechanical tests of the cadaver spine, this study aimed to comparatively analyze the kinematic responses of the spine with dynamic and rigid fixations (i.e., Coflex fixation and posterolateral fusion) after single-or double-level lumbar fusion in daily activities. Methods: Six human lumbar specimens (L1-S1) were selected for this experiment, and the sagittal parameters of each lumbar specimen were measured in the 3D model. The specimens were successively reconstructed into five groups of models: intact model, single-level L4-5 Coflex fixation model, single-level L4-5 Fusion (posterior pedicle screw fixation) model, double-level L4-5 Coflex + L5-S1 Fusion model; and double-level L4-5 Fusion + L5-S1 Fusion model. The pure moment was applied to the specimen model to simulate physiological activities in daily life through a custom-built robot testing device with an optical tracking system. Results: For single-level lumbar fusion, compared to the traditional Fusion fixation, the Coflex dynamic fixation mainly restricted the extension of L4-L5, partially retained the range of motion (ROM) of the L4-L5 segment, and reduced the motion compensation of the upper adjacent segment. For the double-level lumbar fixation, the ROM of adjacent segments in the Coflex + Fusion was significantly decreased compared to the Fusion + Fusion fixation, but there was no significant difference. In addition, PT was the only sagittal parameter of the preoperative lumbar associated with the ROM under extension loading. The Coflex fixation had little effect on the original sagittal alignment of the lumbar spine. Conclusion: The Coflex was an effective lumbar surgical technique with a less altering kinematic motion of the lumbar both at the index segment and adjacent segments. However, when the Coflex was combined with the fusion fixation, this ability to protect adjacent segments remained elusive in slowing the accelerated degradation of adjacent segments.

Age- and sex-dependent differences in the morphology and composition of paraspinal muscles between subjects with and without lumbar degenerative diseases.

BACKGROUND: The quality of the paraspinal muscles has been recommended as a surrogate marker for the evaluation of the severity of the lumbar degenerative diseases (LDD). The purpose of this study is to determine the age- and sex-dependent differences in the morphology and composition of the paraspinal muscles between LDD and asymptomatic subjects. METHODS: We analyzed data from 370 patients and 327 asymptomatic volunteers aged between 18-85 years. The measurement of the cross-sectional area (CSA) of the erector spinae, multifidus, and psoas at the L4/5-disc level was performed by the magnetic resonance imaging (MRI). The fatty infiltration ratio (FI %) of the multifidus and erector spinae was calculated. RESULTS: FI % of the lumbar paraspinal muscles were significantly and positively correlated with the severity of LDD instead of the CSA. Males had greater CSA than females, and females showed higher FI % than males in the paraspinal muscles. With the increase of age, the CSA of the lumbar paraspinal muscles gradually decreased, and the psoas showed the most significant decreasing trend. However, the FI % gradually increased in both LDD and asymptomatic groups with aging. CONCLUSION: Age- and sex-dependent differences were found in the morphology and composition of the paraspinal muscles between subjects with and without LDD. Further long-term follow up investigations and basic studies will continue to confirm the natural history of the paraspinal muscles with aging and their association with LDD.

Predictors for the restoration of the sagittal spinal malalignment in patients with lumbar stenosis after short-segment decompression and fusion surgery.

BACKGROUND: To explore the predictors for the restoration of the sagittal spinal malalignment in the elderly patients with lumbar spinal stenosis (LSS) after short-segment decompression and fusion surgery. METHODS: We retrospectively reviewed 82 LSS patients with sagittal malalignment (SVA ≥ 50 mm or PT ≥ 20° or PI-LL ≥ 20°) who underwent short-segment decompression and fusion surgery between January 2019 and March 2021. Patients' characteristic, radiographic and paravertebral muscle parameters were assessed. The patients were divided into group A (postoperative malalignment) and B (postoperative alignment) according to whether the postoperative restoration of the sagittal alignment was achieved. RESULTS: There existed more males in group B than in group A (p = 0.002). The age of group A (73.36 ± 8.02) was greater than that of group B (69.08 ± 6.07, p = 0.009). Preoperative PT in group A (27.40 ± 5.82) was greater than that in group B (19.30 ± 7.32, p < 0.001). The functional cross-sectional area (fCSA) in group A (28.73 ± 4.23) was lower than that in group B (36.94 ± 7.81, p < 0.001). And the fatty infiltration rate (FI) of group A (27.16% ± 5.58%) was higher than that of group B (22.61% ± 5.81%, p = 0.001). The fCSA was negatively correlated with the postoperative PT and PTr (p < 0.05). CONCLUSION: Stronger lumbar paravertebral muscles, smaller preoperative PI, PT or PI-LL, male and younger age are the predictors for the restoration of the sagittal spinal malalignment in the elderly LSS patients after short-segment decompression and fusion surgery.

Influence of Sagittal Lumbopelvic Morphotypes on the Range of Motion of Human Lumbar Spine: An In Vitro Cadaveric Study.

BACKGROUND: Although spinopelvic radiographs analysis is the standard for a pathological diagnosis, it cannot explain the activities of the spine in daily life. This study investigates the correlation between sagittal parameters and spinal range of motion (ROM) to find morphological parameters with kinetic implications. METHODS: Six L1-S1 human lumbar specimens were tested with a robotic testing device. Eight sagittal parameters were measured in the three-dimensional model. Pure moments were applied to simulate the physiological activities in daily life. RESULTS: The correlation between sagittal parameters and the ROM was moderate in flexion and extension, but weak in lateral bending and rotation. In flexion-extension, the ROM was moderately correlated with SS and LL. SS was the only parameter correlated with the ROM under all loading conditions. The intervertebral rotation distribution showed that the maximal ROM frequently occurred at the L5-S1 segment. The minimal ROM often appeared near the apex point of the lumbar. CONCLUSION: Sagittal alignment mainly affected the ROM of the lumbar in flexion and extension. SS and apex may have had kinetic significance. Our findings suggest that the effect of sagittal parameters on lumbar ROM is important information for assessing spinal activity.

Does the sagittal spinal profile differ between the elderly Chinese populations with and without lumbar disc herniation?

OBJECTIVE: To explore the characteristics of the sagittal spinopelvic profile in the elderly Chinese population with lumbar disc herniation (LDH) and to evaluate its influence on the severity, location and number of disc degeneration. METHODS: A retrospective analysis was conducted on 212 elderly Chinese patients with LDH and 213 asymptomatic volunteers with matched age and sex. Sagittal spinopelvic parameters were measured on the full-length X-ray and the sagittal profiles were determined according to the Roussouly classification. The severity, location and number of lumbar disc degeneration were evaluated from the L12 to L5S1 discs on the MRI images. RESULTS: There were no significant differences in BMI between the two groups. Patients with LDH were found to have significantly smaller TK, LL, and SS than those in the asymptomatic population (P < 0.05), while contradicting observations were obtained of PT and TPA (P < 0.05). In the LDH group, Roussouly type 1 and type 2 (50.4% and 28.7%, respectively) were predominant and the proportion of type 1 in the elderly LDH population was further increased compared to the younger LDH population. LDH population with Roussouly type 1 and 2 showed more caudal herniated locations and fewer herniated numbers than those with type 3 and 4. CONCLUSION: The sagittal spinopelvic profile was significantly different between the elderly Chinese population with and without LDH. There were significant differences in the Roussouly distribution between the elderly and the younger groups and different Roussouly types have different effects on the lumbar disc degeneration patterns.

Characteristics of the sagittal spinal balance in the asymptomatic elderly Chinese population.

PURPOSE: To investigate the normal values of the sagittal spinal parameters and analyze the distribution of the global spinal profiles in a Chinese population with age over 75. METHODS: Two hundred and twelve sets of the whole spine lateral radiographs were obtained from a database of an asymptomatic elderly population. Global and regional spinal parameters were measured. Sagittal profiles were determined according to the Roussouly classification compared with previous studies involving different populations. RESULTS: A total of 102 elderly subjects (≥ 75 years) were enrolled with an average age of 79.24 ± 3.53 years. The mean values of the spinopelvic parameters were 42.89 ± 11.64° for TK, 13.84 ± 10.78° for TLK, 44.48 ± 12.88° for LL, 44.76 ± 9.84° for PI, 17.19 ± 8.08° for PT, 28.35 ± 7.94° for SS, 3.47 ± 3.56 cm for SVA, 14.75 ± 7.85° for TPA, -0.27 ± 11.95° for PI-LL, respectively. Subjects ≥ 75 years were found to have significantly smaller LL and SS, but greater TLK, PT, SVA, TPA, and PI-LL than those 60-74 years (p < 0.05). Significant age- and sex-dependent differences were found in the Roussouly classification's distribution between the two subgroups. CONCLUSIONS: The normal values of the sagittal parameters were presented in the elderly Chinese asymptomatic population (≥ 75 years). Ethnic, age, and sex displayed significant effects on the behaviors of the sagittal spinal balance and profiles. These results could be served as physiological references for the planning of surgical strategies in elderly Chinese patients over 75 years.

Sex-Dependent Estimation of Spinal Loads During Static Manual Material Handling Activities-Combined in vivo and in silico Analyses.

Manual material handling (MMH) is considered as one of the main contributors to low back pain. While males traditionally perform MMH tasks, recently the number of females who undertake these physically-demanding activities is also increasing. To evaluate the risk of mechanical injuries, the majority of previous studies have estimated spinal forces using different modeling approaches that mostly focus on male individuals. Notable sex-dependent differences have, however, been reported in torso muscle strength and anatomy, segmental mass distribution, as well as lifting strategy during MMH. Therefore, this study aimed to use sex-specific models to estimate lumbar spinal and muscle forces during static MHH tasks in 10 healthy males and 10 females. Motion-capture, surface electromyographic from select trunk muscles, and ground reaction force data were simultaneously collected while subjects performed twelve symmetric and asymmetric static lifting (10 kg) tasks. AnyBody Modeling System was used to develop base-models (subject-specific segmental length, muscle architecture, and kinematics data) for both sexes. For females, female-specific models were also developed by taking into account for the female's muscle physiological cross-sectional areas, segmental mass distributions, and body fat percentage. Males showed higher absolute L5-S1 compressive and shear loads as compared to both female base-models (25.3% compressive and 14% shear) and female-specific models (41% compressive and 23.6% shear). When the predicted spine loads were normalized to subjects' body weight, however, female base-models showed larger loads (9% compressive and 16.2% shear on average), and female-specific models showed 2.4% smaller and 9.4% larger loads than males. Females showed larger forces in oblique abdominal muscles during both symmetric and asymmetric lifting tasks, while males had larger back extensor muscle forces during symmetric lifting tasks. A stronger correlation between measured and predicted muscle activities was found in females than males. Results indicate that female-specific characteristics affect the predicted spinal loads and must be considered in musculoskeletal models. Neglecting sex-specific parameters in these models could lead to the overestimation of spinal loads in females.

Characteristics of Lumbar Flexion Rhythm at Different Arm Positions.

BACKGROUND: The lumbar spine displays its greatest mobility in ventral flexion, which is a potential risk factor for low back pain. The relative contribution of each segment to the complete flexion is denoted the spine rhythm, which is required to distinguish between normal and abnormal spinal profiles, and as well to calculate the spinal forces in musculoskeletal models. Nevertheless, different spine rhythms have been reported in literature and the effect of arm position has not been demonstrated. We therefore aimed to investigate the effects of different arm positions on spine rhythm during ventral flexion. METHODS: A nonradiologic back measurement device was used to determine the real-time back lordosis during ventral flexion while participants (10 male and 10 female without low back pain) held their arms at 6 different positions. RESULTS: During flexion with the arms naturally hanging down at both sides, the lumbar range of flexion was 52.6° ± 13.1°. Different arm positions displayed nonsignificant effect on lumbar range of flexion (P > 0.05). The middle and lower levels contributed more to the whole lumbar range of flexion than the upper level (P < 0.05), which is independent of arm position. CONCLUSIONS: The lumbar spine displayed greater flexion in the middle and lower levels and its flexion rhythm remained unchanged at different arm positions. These results strike importance to explore for more reasons explaining the different lumbar flexion rhythms reported in literature.

Engineered collagen-binding bone morphogenetic protein-2 incorporated with platelet-rich plasma accelerates lumbar fusion in aged rats with osteopenia.

In aged individuals, osteopenia is a great concern for achieving solid spinal fusion. Spinal malunion could lead to various implant-related complications and reduce postoperative quality of life. This study aims to investigate the efficacy of collagen-binding bone morphogenetic protein-2 (CBD-BMP-2) on the treatment of lumbar inter-transverse defects and to explore whether platelet-rich plasma could help CBD-BMP-2 to achieve a better outcome in terms of osteogenesis in senile rats with osteopenia. In vitro experiment proved the angiogenic function of platelet-rich plasma and osteogenic effect of CBD-BMP-2. Rats were performed posterolateral lumbar inter-transverse fusion. Rats implanted with CBD-BMP-2 + platelet-rich plasma were assigned to Group A (n = 20), rats implanted with CBD-BMP-2 were assigned to Group B (n = 20), and those with platelet-rich plasma were assigned to Group C (n = 20). Four weeks after implantation, radiographic assessment, manual palpation, and histological evaluation were performed. In vivo experiments showed satisfactory therapeutic effect on lumbar inter-transverse fusion in both Groups A and B and better results of bone microarchitecture in Group A. Solid fusion rate was 77.8% in Group A, 66.7% in Group B, and 0% in Group C (P < 0.001). Our study indicated that CBD-BMP-2 could effectively facilitate the lumbar inter-transverse fusion in aged rats with osteopenia and platelet-rich plasma could help CBD-BMP-2 to enhance the bone healing of vertebral defects.

The sagittal sways of back lordosis and sacral orientation during still standing at different arm positions.

Lumbo-pelvic parameters in the sagittal plane are normally measured from lateral radiographs obtained at a single time point during upright standing with arms held forward to expose anatomical bony structures. However, the human trunk naturally sways during still standing, which potentially alters the targeted parameters. We therefore aimed to investigate the effect of postural sway on lumbo-pelvic parameters during still standing at different arm positions. A non-radiological back measurement device was used to determine the absolute changes of back lordosis and sacral orientation during one-minute still standing while participants (10 males and 10 females without low back pain) held their arms at eight different positions. When the arms were freely hanging down at both sides, males displayed median values of 25.2° (range: 15.6-45.0°) and 7.4° (range: 2.0-26.7°) for back lordosis and sacral orientation, which were smaller than those of 33.1° (range: 11.9-41.9°) and 16.1° (range: 0.8-22.8°) for females, respectively (P < 0.05). At the same arm position, the median values were 2.7° (range: 1.3-5.2°) and 2.9° (range: 1.6-4.5°) for change of back lordosis and change of sacral orientation, respectively. Sex displayed no significant influence for both measures. Different arm positions non-significantly affected the change of back lordosis. When hands rested on horizontal bars, the change of sacral orientation was significantly less than during other arm positions (P < 0.05). Hence, back lordosis and sacral orientation inherently change during still standing, independently of sex and arm position, which could compromise the reliability of measurements at a single time point. When categorizing subjects into groups with normal or abnormal lumbo-pelvic balance, this variability should be taken into consideration.

Lumbar Muscle Fat Content Has More Correlations with Living Quality than Sagittal Vertical Axis in Elderly Patients with Degenerative Lumbar Disorders.

PURPOSE: As the most poorly tolerated and debilitating form of spinal malalignment, sagittal imbalance is becoming an increasingly recognized cause of pain and disability in adults. However, there is evidence showing that sagittal imbalance has a weak or no correlation with health-related quality-of-life (HRQoL) outcomes. The objective of this study was to describe the direct factor associated with HRQoL in terms of Oswestry Disability Index (ODI) assessment. PATIENTS AND METHODS: This study retrospectively evaluated the clinical and radiographic information of 179 elderly patients with degenerative lumbar disorders and suboptimal sagittal standing posture (sagittal vertical axis>50 mm). Patient-reported outcomes were assessed using ODI. Patients with ODI≥40% were assigned to Group D (disability), while those with ODI<40% were assigned to Group ND (non-disability). RESULTS: Compared with Group ND (n=104), patients in Group D (n=75) had greater thoracolumbar kyphosis, pelvic incidence-lumbar lordosis (PI-LL), sagittal vertical axis (SVA), T1 pelvic angle, and fat infiltration, and smaller LL and muscle mass ratio. Pearson analysis revealed a high correlation between the percentage of fat infiltrated and ODI (r=768, P<0.01) and moderate correlation between SVA and ODI (r=0.408, P<0.001). Linear regression results indicated that fat infiltration was an independent factor associated with ODI. ODI significantly correlated with SVA in patients with major fat infiltration (r=0.328, P=0.001), while having no correlation with SVA in those with moderate or minor fat infiltration (r=0.083, P=0.464). CONCLUSION: Lumbar muscle fat infiltration is an independent factor associated with the living quality in terms of ODI assessment in the elderly population with degenerative lumbar disorders, which has more correlations with ODI scores than the sagittal imbalance. The relationship between HRQoL outcomes and sagittal imbalance depends on the quality of lumbar muscle.

No consensus on causality of spine postures or physical exposure and low back pain: A systematic review of systematic reviews.

Specific spinal postures and physical activities have been linked to low back pain (LBP) but previous reviews have produced contrasting outcomes. This umbrella review examined (1) what relationship, if any, is evident between specific spinal postures or physical activities and LBP; (2) the quality of existing systematic reviews in this area; and (3) the extent to which previous systematic reviews demonstrate causality. Five electronic databases and reference lists of relevant articles were searched from January 1990 to June 2018. Systematic reviews and meta-analyses on spine posture or physical exposure and LBP symptoms (self-report) or outcomes (e.g. work absence, medical consultation) were included. The AMSTAR and the Bradford Hill Criteria were utilised to critically appraise the quality of included systematic reviews and to determine the extent to which these reviews demonstrated causality. Two independent reviewers screened 4285 publications with 41 reviews included in the final review. Both positive and null associations between spine posture, prolonged standing, sitting, bending and twisting, awkward postures, whole body vibration, and components of heavy physical work were reported. Results from meta-analyses were more consistently in favour of an association, whereas systematic reviews that included only prospective studies were less able to provide consistent conclusions. Evidence that these factors precede first time LBP or have a dose response relationship with LBP outcomes was mixed. Despite the availability of many reviews, there is no consensus regarding causality of physical exposure to LBP. Association has been documented but does not provide a causal explanation for LBP.

Which is the best-suited landmark to assess the thoracic orientation?

Several skin surface-based techniques exist to non-invasively determine the spinal kinematics. However, the accuracy of these techniques is limited by soft-tissue artefacts. Furthermore, structures like the thorax are frequently assumed to be rigid but display considerable mobility within itself. This study aimed to quantify the accuracy at different thoracic landmarks for measuring mobility in healthy individuals during different activities to provide a recommendation for the best suited measurement location. The locations of 29 landmarks were continuously captured on 19 individuals (age: 25-59 years) during sitting, standing, walking, jumping, intra-thoracic motions, and different breathing depths using reflective markers. Marker triplets were used at every landmark to calculate their orientations by first backtracking the rigid-body motion (RBM) of the thorax in general, and subsequently calculating the RBM of each rigid marker triplet. Of the latter, the maximum axis angle for each exercise was statistically evaluated. Landmarks at the middle of the clavicles displayed the largest overall errors (approximately 90° during worst case scenario). However, the variability of errors among the investigated exercises was large. Landmarks at the cranial sternal region (particularly at the "Louis angle") and at the T3 spinous process showed the smallest errors for all subjects and tasks (e.g., <5° and <11°, respectively, during normal breathing). When only one sensor is to be used, it is recommended to use the cranial sternal region to assess the thoracic orientation. Study results highly sensitive to thoracic orientation should be considered with care or performed using more appropriate methods.

Sex-dependent differences in lumbo-pelvic coordination for different lifting tasks: A study on asymptomatic adults.

During manual material lifting, the sagittal motion is mainly characterized through the lumbo-pelvic coordination, which is quantified by the ratio between the lumbar and hip rotations (L/P ratio). Alteration in the L/P ratio is an important indicator for low back pain (LBP). Previous studies demonstrated sex-dependent differences in LBP prevalence during lifting activities. However, the sex-dependent differences in the L/P ratio during different lifting tasks has to data not been investigated. An optoelectronic system was used to measure the sagittal lumbo-pelvic motion in 10 males and 10 females. Task A was lifting one weight from the ground in front of the body to three target heights with straight knees (A1-3: abdomen, chest and head levels, respectively). Task B was lifting two identical weights from the ground at the sides of the body to three target angles with bended knees (B1-3: arms close and 45° and 90° abducted to the trunk, respectively). Lifts of 10 kg (males and females) and 20 kg (males only) were performed and three phases were investigated: Phase 1 - pure flexion without load, Phase 2 - lifting up weights, Phase 3 - lowering down weights. Females generally displayed a smaller L/P ratio than males. In Phases 2 and 3, the L/P ratio was greater than in Phase 1 for Tasks A and B. The L/P ratio increased with a greater lifting height for Task B, but displayed no difference neither between lifting 10 kg and 20 kg, nor between weight lifting and lowering for both tasks. These results can provide indications for sex-specific recommendations for safer lifting activities.

How reproducible do we stand and sit? Indications for a reliable sagittal spinal assessment.

BACKGROUND: Currently, an upright standing posture is normally adopted for evaluations of spinal alignment, which is however sensitive to posture variations. Thus, finding a reproducible reference is essential. This study aimed to evaluate the reproducibility of standing and sitting postures at different arm positions in five consecutive repetitions. METHODS: 22 asymptomatic subjects (11 males; 11 females) aged 20-35 years were included. Subjects were repeatedly asked to adopt different arm positions in standing and sitting. The absolute reposition errors of lumbar lordosis and sacral orientation between two consecutive repetitions were assessed with a non-radiological back measurement system. FINDINGS: During standing at the relaxed arm position, the median absolute reposition errors of lumbar lordosis and sacral orientation were 1.14° (range 0.23°-3.80°) and 0.92° (range 0.17°-3.27°), respectively, which increased to 1.75° (range 0.21-4.97°) and 1.36° (range 0.35°-4.08°) during sitting (P < 0.01). The absolute reposition error of lumbar lordosis was non-significantly lower at the relaxed and clasped arm positions than at other arm positions. Between the first two repetitions, the absolute reposition errors of both, lumbar lordosis and sacral orientation, were greater than between the remaining two consecutive repetitions (P < 0.01). Both during standing and sitting, lumbar lordosis was smallest when hands holding two bars (P < 0.05). INTERPRETATION: Sitting showed a worse reproducibility than standing. When assessing sagittal spinal balance, the clasped arm position during standing is recommended and an initial trial can help to reduce inception irreproducibility.

Effect of age and sex on lumbar lordosis and the range of motion. A systematic review and meta-analysis.

Lumbar lordosis (LL) and the range of motion (RoM) are important physiological measurements when initiating any diagnosis and treatment plan for patients with low back pain. Numerous studies reported differences in LL and the RoM due to age and sex. However, these findings remain contradictory. A systematic review and meta-analysis were performed to synthesize mean values and the differences in LL and the RoM because of age and sex. The quality assessment tool for quantitative studies was applied to assess the methodological quality of the studies included. We identified 2372 papers through electronic (2309) and physical (63) searches. We assessed 218 full-text studies reporting measurements of LL or the RoM. In total, 65 studies were included, and a normative database for LL and the RoM is provided as supplementary material. Among these, 11 were included in the meta-analysis. LL and the RoM displayed non-monotonic variations with significant age and sex differences. Young females showed a significantly greater LL and the range of extension (RoE), whereas young males exhibited a greater range of flexion (RoF). Sex differences in the range of lateral bending (RoLB) were small but were significant for the axial rotation (RoAR). For the RoF, RoE and RoLB, differences because of age were significant among most of the age groups in both sexes, whereas for the RoAR, differences were significant only between the 20s vs the 30s-40s (males) and 40s vs 50s (females). Significant differences because of age/sex were identified. However, the age-dependent reduction in LL and the RoM was non-monotonic and differed in both sexes. These findings will help to better distinguish between functional deficits caused by spinal disorders and natural factors/conditions related to age and sex.