[The clinico-immunological characteristics of the treatment of patients with a severe course of bronchial asthma using the method of the extracorporeal incorporation of pig donor spleen]. / Kliniko-immunologicheskaia kharakteristika lecheniia bol'nykh s tiazhelym techeniem bronkhial'noi astmy metodom ékstrakorporal'nogo podkliucheniia donorskoi selezenki svin'i.

A comprehensive clinical-and-immunological evaluation was done of efficiency of treatment of patients with severe forms of bronchial asthma (BA) by hemosorption through donor porcine spleen, xenosorption (XS), in 63 patients. XS was found out to have a marked positive clinical effect manifested by a considerable decrease of frequency of asphyxiation bouts and amounts of inhalation broncholytics being taken within the first 24 hours after the procedure. By day 14 from the start of XS we succeeded in lowering the systemic corticosteroids maintenance dose on the average 2.5 times as little. Positive clinical dynamics correlated with positive immunologic changes which revealed themselves in normalization of numbers as well as functional activity of T-cells, rise in T-helpers, normalization of content of serum immunoglobulins A, M and G, with the parameters characterizing the system of phagocytosis approaching the norm, the processes of autoimmunization getting more attenuated.

[The comparative efficacy of hemosorption and xenosorption in bronchial asthma patients]. / Sravnitel'naiaéffektivnost' gemosorbtsii i ksenosorbtsii u bol'nykh bronkhial'noi astmoi.

The authors studied comparative clinical, immunologic, laboratory and functional effectiveness of hemosorption (HS) on charcoals and xenosorption (XS) on donor pig spleen in bronchial asthma patients. XS was administered in 60 patients, HS was applied to 91 patient. There was no significant difference in immunologic characteristics between the patient groups. However, XS had a more apparent positive influence on the external respiratory function, degree of allergy and unspecific inflammation, as well as on general clinical effectiveness.

[The clinico-immunological characteristics of bronchial asthma patients undergoing autologous ultraviolet blood irradiation]. / Kliniko-immunologicheskaia kharakteristika bol'nykh bronkhial'noi astmoi pri ul'trafioletovom obluchenii autokrovi.

Ultraviolet irradiation of blood studied in 201 patients with various forms of bronchial asthma proved to be the most effective in "aspirin" and infectious-allergic forms of the disease. Analysis of immunological changes showed that ultraviolet irradiation of blood brings to the norm content of IgG in serum, influence beneficially quantity and functional activity of T-lymphocytes, reduces auto-immunization and sensibilization to Streptococcus.