RESUMO
Advanced graphene-based materials have been proficiently incorporated into next-generation solar cells and supercapacitors because of their high electrical conductivity, large surface area, excellent charge-transport ability, and exceptional optical properties. Herein, we report the synthesis of graphene nanosheets (GNs) from waste cardboard via pyrolysis, with ethyl alcohol as the growth initiator. Additionally, we demonstrated the use of GNs in energy conversion and storage applications. Using the GN electrode in perovskite solar cells resulted in an excellent power conversion efficiency of â¼10.41 % for an active area of 1 cm2, indicating an enhancement of approximately 27 % compared to conventional electrodes. Furthermore, the GNs were used as active electrode materials in supercapacitors with excellent electrochemical performance and a high gravimetric specific capacitance of 167.5 F/g at a scan rate of 2 mV/s. The developed GNs can be efficiently used for energy storage, conversion, and electrochemical sensing applications.
RESUMO
Background: The purpose of this study is to explore the effect of vitamin B complex supplementation following periodontal flap surgery on clinical and microbiological parameters. Materials and Methods: A randomized controlled trial on 10 patients with periodontitis in split-mouth design was undertaken to find the effect of vitamin B complex supplementation with open flap debridement on periodontal wound healing. Multiplex polymerase chain reaction (PCR) for Tannerella forsythus and Porphyromonas gingivalis was done using subgingival plaque samples at 0 and 90th day. Results: The results showed a significant reduction (P < 0.01) of clinical (plaque index, gingival index, gingival bleeding index, probing pocket depth, and relative attachment level) and microbial profile in both treatment groups, whereas on intergroup analysis, more reduction in all clinical parameters were observed in the test group, but statistically, the results were insignificant.
RESUMO
Metabolic reprogramming occurs to meet cancer cells' high energy demand. Its function is essential to the survival of malignancies. Comparing cancer cells to non-malignant cells has revealed that cancer cells have altered metabolism. Several pathways, particularly mTOR, Akt, PI3K, and HIF-1 (hypoxia-inducible factor-1) modulate the metabolism of cancer. Among other aspects of cancer biology, gene expression in metabolism, survival, invasion, proliferation, and angiogenesis of cells are controlled by HIF-1, a vital controller of cellular responsiveness to hypoxia. This article examines various cancer cell metabolisms, metabolic alterations that can take place in cancer cells, metabolic pathways, and molecular aspects of metabolic alteration in cancer cells placing special attention on the consequences of hypoxia-inducible factor and summarising some of their novel targets in the treatment of cancer including leukemia. A brief description of HIF-1α's role and target in a few common types of hematological malignancies (leukemia) is also elucidated in the present article.
Assuntos
Leucemia , Humanos , Leucemia/metabolismo , Leucemia/patologia , Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo , Fator 1 Induzível por Hipóxia/metabolismo , Animais , Transdução de SinaisRESUMO
Buerger's disease (BD) remains a debilitating condition and early diagnosis is paramount for its effective management. Despite many published diagnostic criteria for BD, selective criteria have been utilized in different vascular centers to manage patients with BD worldwide. A recent international Delphi Consensus Study on the diagnostic criteria of BD showed that none of these published diagnostic criteria have been universally accepted as a gold standard. Apart from the presence of smoking, these published diagnostic criteria have distinct differences between them, rendering the direct comparison of patient outcomes difficult. Hence, the expert committees from the Working Group of the VAS-European Independent Foundation in Angiology/Vascular Medicine critically reviewed the findings from the Delphi study and provided practical recommendations on the diagnostic criteria for BD, facilitating its universal use. We recommend that the 'definitive' diagnosis of BD must require the presence of three features (history of smoking, typical angiographic features and typical histopathological features) and the use of a combination of major and minor criteria for the 'suspected' diagnosis of BD. The major criterion is the history of active tobacco smoking. The five minor criteria are disease onset at age less than 45 years, ischemic involvement of the lower limbs, ischemic involvement of one or both of the upper limbs, thrombophlebitis migrans and red-blue shade of purple discoloration on edematous toes or fingers. We recommend that a 'suspected' diagnosis of BD is confirmed in the presence of a major criterion plus four or more minor criteria. In the absence of the major criterion or in cases of fewer than four minor criteria, imaging and laboratory data could facilitate the diagnosis. Validation studies on the use of these major and minor criteria are underway.
Assuntos
Tromboangiite Obliterante , Humanos , Pessoa de Meia-Idade , Tromboangiite Obliterante/diagnóstico , Fumar , AngiografiaRESUMO
Background Inflammation plays a very important role in the pathogenesis of a wide range of diseases, such as atherosclerosis myocardial infarction, sepsis, rheumatoid arthritis, and cancer. This study aimed to investigate the association of IL-8 in T-cell acute lymphoblastic leukemia (T-ALL) patients. Methodology IL-8 levels were estimated in 52 individuals. Of the study population, 26 were T-ALL patients (all phases of leukemia were included in the study) and 26 were disease-free healthy volunteers. In this study, we employed flow cytometry, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction test, and western blot analysis. Results IL-8 was significantly higher in all T-ALL patients than in healthy volunteers. IL-8 levels showed a significant positive correlation in T-ALL patients at the genomic and proteomic levels. Conclusions Higher serum IL-8 levels were associated with the advanced disease stage of the clinicopathological parameters. Our results indicate that monitoring IL-8 has a role in modulating disease sensing in T-ALL and may represent a target for innovative diagnostic and therapeutic strategies.
RESUMO
Perovskite single crystals are actively studied as X-ray detection materials with enhanced sensitivity. Moreover, the feasibility of using perovskites for self-powered devices such as photodetectors, UV detectors, and X-ray detectors can significantly expand their application range. In this work, the charge carrier transport and photocurrent properties of MAPbBr3 single crystals (MSCs) are improved by the mechanochemical surface treatment using glycerin combined with an additional electrode design that forms an ohmic contact. The sensitivity of MSC-based detectors and pulse shape generated by X-rays are enhanced at various bias voltages. The synthesized MSC detectors generate direction-dependent photocurrents, which indicate the presence of a polarization-induced internal electric field. In addition, photocurrent signals are produced by X-rays with energies greater than 1 MeV under a zero-bias voltage. This work demonstrates a high application potential of perovskites as self-powered detectors for X-rays with energies exceeding 1 MeV.
RESUMO
Presently, carbon-based nanomaterials have shown tremendous potential for energy conversion applications. Especially, carbon-based materials have emerged as excellent candidates for the fabrication of halide perovskite-based solar cells, which may lead to their commercialization. In the last decade, PSCs have rapidly developed, and these hybrid devices demonstrate a comparable performance to silicon-based solar cells in terms of power conversion efficiency (PCE). However, PSCs lag behind silicon-based solar cells due to their poor stability and durability. Generally, noble metals such gold and silver are employed as back electrode materials during the fabrication of PSCs. However, the use of these expensive rare metals is associated with some issues, urgently necessitating the search for cost-effective materials, which can realize the commercial applications of PSCs due to their interesting properties. Thus, the present review shows how carbon-based materials can become the main candidates for the development of highly efficient and stable PSCs. Carbon-based materials such as carbon black, graphite, graphene nanosheets (2D/3D), carbon nanotubes (CNTs), carbon dots, graphene quantum dots (GQDs) and carbon nanosheets show potential for the laboratory and large-scale fabrication of solar cells and modules. Carbon-based PSCs can achieve efficient and long-term stability for both rigid and flexible substrates because of their high conductivity and excellent hydrophobicity, thus showing good results in comparison to metal electrode-based PSCs. Thus, the present review also demonstrates and discusses the latest state-of-the-art and recent advances for carbon-based PSCs. Furthermore, we present perspectives on the cost-effective synthesis of carbon-based materials for the broader view of the future sustainability of carbon-based PSCs.
RESUMO
OBJECTIVES: This study was aimed to compare the stability of stainless steel and titanium miniscrew implants of the same diameter and length during en masse retraction of maxillary and mandibular anterior teeth. MATERIALS AND METHODS: Forty miniscrew implants (1.3 mm diameter and 8 mm length) were placed in 10 patients (20 titanium and 20 stainless steel). Stability was checked at insertion (T0), at one month (T1), and at sixth months (T2) and the amount of retraction was recorded in millimeters. RESULTS: Titanium and stainless steel implants were equally stable at the time of insertion. At T1, three titanium miniscrew implants showed grade 2 mobility, whereas seven stainless steel miniscrew implants showed grade 2 mobility. For T2, none of the titanium miniscrew implants had grade 2 mobility while four stainless steel miniscrew implants resulted in grade 2 mobility. Both had an equal frequency of grade 3 and grade 4 mobility. However, the difference in the stability was not statistically significant. No statistical significance was found when the amount of retraction achieved by titanium and stainless steel miniscrew implants was compared between the maxillary and mandibular arches. CONCLUSION: Both titanium and stainless steel miniscrew implants provide good anchorage and remain stable during en masse retraction of maxillary and mandibular anterior teeth. Thus, both miniscrews are clinically effective.
RESUMO
We report the effect of incorporating functionalized graphene oxide (terephthalic acid functionalized GO; GO-g-TPA) on the thermal and mechanical properties of Hytrel (HTL; a thermoplastic elastomeric polymer). Initially, the synthesis of GO-g-TPA was performed via chemical methods and subsequently characterized using various spectroscopic and imaging techniques. The melt mixing technique was executed in preparing the nanocomposites of HTL/GO and HTL/GO-g-TPA. An excellent GO dispersion was observed in the HTL polymeric matrix, which could be attributed to the significant effect of hydrogen bonding and π-π interaction between the HTL and GO-g-TPA. As a result of incorporating GO and GO-g-TPA into the HTL matrix, the overall mechanical and thermal properties of the nanocomposites were significantly improved. For the HTL/5 wt% GO-g-TPA nanocomposite, the tensile strength and storage modulus significantly increased by 61% and 224%, respectively. In addition, the melting temperature and crystalline temperature are increased by a notable 20 °C and 21 °C, respectively. Thus, the current study found that by improving the dispersion ability of the GO sheets, the properties of the HTL can be significantly enhanced and the prepared composite materials can be relevant for a wide range of applications including sports goods, hose jackets, wire and cable jackets, electronics, fluid power, sheeting belting seals, and footwear, etc.
RESUMO
This position paper, written by members of International Union of Angiology (IUA) Youth Committee and senior experts, shows an overview of therapeutical approaches for patients with chronic limb-threatening ischemia (CLTI) and absence of 'standard' solutions for revascularization. The aim was to demonstrate the accurate management of the 'no-option' CLTI patient including the wound treatment and the rehabilitation, considering always the goal of the increase of quality of life of the patients.
Assuntos
Cardiologia , Doença Arterial Periférica , Adolescente , Humanos , Amputação Cirúrgica , Doença Crônica , Isquemia Crônica Crítica de Membro , Isquemia/diagnóstico , Isquemia/terapia , Salvamento de Membro , Doença Arterial Periférica/diagnóstico , Doença Arterial Periférica/terapia , Qualidade de Vida , Estudos Retrospectivos , Fatores de Risco , Resultado do TratamentoRESUMO
Depression is one of the significant mental health issues affecting all age groups globally. While it has been widely recognized to be one of the major disease burdens in populations, complexities in definitive diagnosis present a major challenge. Usually, trained psychologists utilize conventional methods including individualized interview assessment and manually administered PHQ-8 scoring. However, heterogeneity in symptomatic presentations, which span somatic to affective complaints, impart substantial subjectivity in its diagnosis. Diagnostic accuracy is further compounded by the cross-sectional nature of sporadic assessment methods during physician-office visits, especially since depressive symptoms/severity may evolve over time. With widespread acceptance of smart wearable devices and smartphones, passive monitoring of depression traits using behavioral signals such as speech presents a unique opportunity as companion diagnostics to assist the trained clinicians in objective assessment over time. Therefore, we propose a framework for automated depression classification leveraging alterations in speech patterns in the well documented and extensively studied DAIC-WOZ depression dataset. This novel tensor-based approach requires a substantially simpler implementation architecture and extracts discriminative features for depression recognition with high f1 score and accuracy. We posit that such algorithms, which use significantly less compute load would allow effective onboard deployment in wearables for improve diagnostics accuracy and real-time monitoring of depressive disorders.
Assuntos
Depressão , Dispositivos Eletrônicos Vestíveis , Algoritmos , Estudos Transversais , Depressão/diagnóstico , FalaRESUMO
The effect of organic solvents on alkaline proteases was assessed for native, recombinant, and metagenomically derived alkaline proteases. Their stability and the effects of physicochemical parameters were studied in the presence of hexane. The native enzyme was comparatively more resistant against the organic solvents than the recombinant counterparts. On the other hand, the metagenomically derived alkaline protease was minimally resistant against solvents. A similar trend was apparent for the stability of enzyme in organic solvents. The novelty of this study lies in the fact that the majority of the studies on the solvent tolerance have focused on the mesophilic enzymes, while those from the haloalkaliphilic bacteria have received little attention. The comparative tolerance of the native, recombinant, and metagenomic alkaline proteases against the organic solvent has practical importance. The phylogenetic relatedness among the various protease sequences will be described.
Assuntos
Hexanos , Peptídeo Hidrolases , Estabilidade Enzimática , Filogenia , Solventes/farmacologia , CatáliseRESUMO
This position paper, written by members of International Union of Angiology (IUA) Youth Committee, shows an overview of coagulation system and laboratory tests, analysis of medical therapies (older and newer), medication discontinuation/restart recommendations, bridging therapy recommendations, and an overview of hemostatic agents used in the operating room.
Assuntos
Cardiologia , Hemostáticos , Adolescente , Humanos , Hemostasia , Procedimentos Cirúrgicos Vasculares/efeitos adversosRESUMO
BACKGROUND: Buerger's disease (BD) remains a debilitating condition. Despite multiple published diagnostic criteria for BD, none is universally accepted as a gold standard. METHODS: We conducted a 2-round modified Delphi consensus study to establish a consensus on the diagnostic. The questionnaire included statements from several commonly used diagnostic criteria for BD. Qualitative and quantitative analysis methods were performed. An agreement level of 70% was applied. RESULTS: Twenty nine experts from 18 countries participated in this study. Overall, 75 statements were circulated in Round 1. Of these, 28% of statements were accepted. Following comments, 21 statements were recirculated in Round 2 and 90% were accepted. Although more than 90% of the experts did not agree that the diagnosis of BD can be based only on clinical manifestation, none of the nonclinical manifestations of BD were agreed as a part of the diagnostic criteria. There was an agreement that a history of tobacco consumption in any form, not necessarily confined to the current use, should be a part of the diagnostic criteria of BD. The history of thrombophlebitis migrans, even if not present at presentation, was accepted as a clue for BD diagnosis. It was also agreed that discoloration of the toes or fingers could be included in the diagnostic criteria of BD. Experts agreed that histology results could differentiate BD from atherosclerosis obliterans and other types of vasculitis. The presence of corkscrew collaterals on imaging and burning pain reached the agreement at the first round but not at the second. There was no consensus regarding age cut-off, the requirement of normal lipid profile, and normal blood glucose for BD diagnosis. CONCLUSIONS: The present study demonstrated discrepancies in the various published diagnostic criteria for BD and their selective utilization in routine clinical practice worldwide. We propose that all published diagnostic criteria for BD be re-evaluated for harmonization and universal use.
Assuntos
Tromboangiite Obliterante , Glicemia , Técnica Delphi , Humanos , Lipídeos , Tromboangiite Obliterante/diagnóstico , Resultado do TratamentoRESUMO
Purpose: The purpose of the study was to evaluate whether the rigid fixation at one site and functional fixation at other site is enough in double mandibular fractures (DMF). The specific aim of the study was assessment of masticatory function on the basis of bite force and other clinical parameters. Methods: A prospective, randomized controlled trial was conducted on patients having DMF. The patients were randomized into 3 groups. Group-1, managed with 2-miniplates at anterior and 1-miniplate at posterior site, group-2 patients managed with one 2.4 mm reconstruction plate at anterior and 1-miniplate at posterior site and in group-3, both fractures were managed with 1-reconstruction plate. Primary outcome variable was bite force. Secondary outcome variables were type of fracture, pain, swelling, mobility between fracture segments, occlusal discrepancy, paresthesia, implant exposure/fracture. Results: The study sample included 60 (20 in each group) patients with mean age of 29.28 ± 12.35 years. Statistically significant difference was seen in bite force from preoperative to follow-up (p = 0.0) in all the groups. Difference in bite force was statistically significant between group 1 and 2 (p = 0.0) and group 1 and 3 (p = 0.0) at follow-up but the difference was statistically insignificant between group 2 and 3. Conclusion: The present study concludes that treatment of DMF with rigid fixation at one site and functional fixation at other fracture site provides enough fixation.
RESUMO
Introduction: Prolotherapy is a nonsurgical regenerative injection technique and effective treatment method for the treatment of temporomandibular joint (TMJ) dislocation. Autologous blood and dextrose are commonly used agents for prolotherapy and the aim of this study is to compare the autologous blood injection prolotherapy and 25% dextrose prolotherapy for the treatment of chronic recurrent TMJ dislocation. Method: This is a retrospective cohort study of 20 patients with chronic recurrent TMJ dislocation who were treated by either autologous blood (Group A) or 25% dextrose Prolotherapy (Group B). After prolotherapy, the patients were kept on follow-up and evaluated for maximum mouth opening (MMO), pain at visual analog scale (VAS), mandibular movements, frequency of dislocation, and TMJ sound. The collected data were then statistically analyzed. Results: Group A showed better results in terms of reduction in MMO, mandibular movements as compared to Group B, and a statistically significant difference was found starting from 2 weeks post prolotherapy till 6 months follow-up. Whereas group B showed better results regarding reduction in pain intensity on VAS Scale at all follow-up visits. No statistically significant difference was found between both groups regarding reduction in the frequency of dislocation and TMJ sounds. Conclusion: Both autologous and dextrose prolotherapy gives promising results for the treatment of recurrent TMJ dislocation, however, regarding reduction in MMO and improvement in lateral and protrusive mandibular movements, autologous blood gave better results whereas 25% Dextrose was found to be more effective in terms of reduction of pain in recurrent TMJ dislocation cases.
RESUMO
Even today thromboangiitis obliterans has disease features that remain misunderstood or underappreciated. The epidemiology, etiology and pathophysiology of the disease are still unclear. Biomarkers and disease activity markers are lacking, thus clinical assessment is difficult. We are still struggling to establish unique diagnostic, staging and treatment criteria. This is an academic-collaborative effort to describe the pathophysiology, the clinical manifestations, the diagnostic approach, and the challenges of management of patients with TAO. A systematic search for relevant studies dating from 1900 to the end of 2020 was performed on the PubMed, SCOPUS, and Science Direct databases. Given the intriguing nature of presentation of TAO, its management, to some extent is not only different in different regions of the world but also varies within the same region. Following this project, we discovered ambiguity, overlap and lack of clear-cut criteria for management of TAO. An international group of experts however came to one conclusion. They all agree that management of TAO needs a call for action for a renewed global look with multi-center studies, to update the geographical distribution of the disease and to establish a unique set of diagnostic criteria and a consensus-based guideline for best treatment based on current evidence.
Assuntos
Cardiologia , Tromboangiite Obliterante , Humanos , Tromboangiite Obliterante/diagnóstico , Tromboangiite Obliterante/epidemiologia , Tromboangiite Obliterante/terapiaRESUMO
The present study reports the upcycling process of waste plastics into value-added product graphene nanosheets (GNs) and their subsequent applications in dye sensitized solar cells (DSSCs) and supercapacitors. Bentonite nanoclay has been used as an agent for the degradation of waste plastics with two step pyrolysis processes at 450 °C and 945 °C in an inert atmosphere of N2 gas to obtain GNs. The GNs with few layers were confirmed by the RAMAN spectroscopy, XRD and HRTEM analyses. Further, FT-IR and EDX analyses also performed for the identification and quantitative analysis of functional groups in GNs. The GNs thus synthesized from plastic waste have been used for the fabrication of DSSCs and supercapacitors. The DSSC fabrication with GNs as part of photo-anode with polymeric electrolyte showed a high fill factor of 86.4% and high Voc of 0.77 V, which were also supported by the computational findings. On the other hand, the utilization of GNs as an active layer material of supercapacitor electrodes offered a high specific capacitance of 398 F/g with a scan rate of 0.005 V/s. The supercapacitor also exhibited significant energy density (Ed) and power density (Pd) of 38 Wh/kg and 1009.74 W/kg, respectively. Thus, the process illustrated the utility of waste plastics upcycling for conservation of EEE i.e., ecology, economy and energy for better tomorrow.
RESUMO
Herein, we report the first time application of waste plastic derived 3D graphene nanosheets (GNs) for hole transport material (HTM) free perovskite solar cells (PSCs), where 3D GNs have been employed as an electrode dopant material in monolithic carbon electrode based mesoscopic PSCs. Waste plastics were upcycled into high-quality 3D GNs by using two-step pyrolysis processes, where, a nickel (99.99%) metal mesh was taken as the catalytic and degradation template to get an acid free route for the synthesis of 3D GNs. Raman spectroscopy, HRTEM analysis and XRD analysis show the presence of 1-2 graphene layers within the 3D GNs. Further, the optical band gap study has also been performed to analyze the applicability of 3D GNs for PSCs. The optimized device with 3D GNs shows a power conversion efficiency (PCE) of 12.40%, whereas the carbon-based control device shows a PCE of 11.04%. Further, all other device parameters such as short circuit current (J sc), open circuit voltage (V oc) and fill factor (FF) have been improved with the addition of 3D GNs. The performance enhancement in 3D GN doped HTM free PSC solar cells is attributed to the enhancement in conductivity and reduced recombination within the device. Further, the photocurrent study shows that the 3D GN device shows better performance as compared to the reference device due to the larger diffusion current. Thus, the upcycling of waste plastics into 3D GNs and their exploitation for application in energy conversion show an effective and potential way to convert waste into energy.
RESUMO
OBJECTIVE: Esophageal schwannoma (ES) are rare and mostly benign neurogenic tumors. The clinical misdiagnosis rate of it is high. In this study, the clinicopathologic features of ES in mainland China were studied to better understand the disease and improve the diagnosis and treatment rate. METHODS: A systematic review was conducted in accordance with PRISMA guidelines. The keywords "esophageal schwannoma", "esophageal neurinoma" and "esophageal neurilemoma" were searched for databases such as Pubmed, EMbase, Wanfang Database and Chinese National Knowledge Infrastructure. The search time frame for database was until July 2019. Combined with our patient, the clinicopathological data and the diagnosis and treatment of ES were summarized. RESULTS: ES occurs in the upper part of the mediastinum and in the thoracic esophagus in most patients in the neck, upper and middle segments. CT and PET/CT examinations can be used for diagnosis, but the differentiation value of both benign and malignant ES is similar. The histopathological findings of forceps biopsy specimens are often difficult to diagnose, and deep tissue biopsies may increase pathological accuracy. EUS-FNA is also recommended for ES diagnosis, but it may also be misdiagnosed. Pathological features include a fusiform arrangement in a palisade-like structure or a tumor cell arranged in a network to form a loose structure. ES characteristic immunohistochemistry results showed that S-100 protein has strong immunological activity. CONCLUSION: The definitive diagnosis requires immunohistochemistry, especially immunological reaction with S-100 protein. The appropriate treatment plan should be selected according to the diameter of the lesion. The overall prognosis of ES is good, but attention should be paid to follow-up.