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Clin Transplant ; 38(8): e15429, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39113667

RESUMO

INTRODUCTION: To facilitate the implementation of controlled donation after circulatory death (cDCD) programs even in hospitals not equipped with a local extracorporeal membrane oxygenation (ECMO) team, some countries have launched a local cDCD network with an ECMO mobile team for normothermic regional perfusion (NRP). In the Tuscany region, in 2021, the Regional Transplant Authority launched a cDCD program to make the cDCD pathway feasible even in peripheral hospitals with NRP mobile teams, which were "converted" existing ECMO mobile teams, composed of highly skilled and experienced personnel. METHODS: We describe the Tuscany cDCD program, (2021-2023), for cDCD from peripheral hospitals with NRP mobile teams. RESULTS: Twenty-six cDCDs (26/40, 65%) came from peripheral hospitals. Following the launch of the cDCD program, cDCDs from peripheral hospitals increased, from 33% (2021) to 75% (2022 and 2023) of the overall cDCDs. The mean age was 63 years, with older donors (>75 years) in half the cases. The median warm ischemia time was 45 min (20 min are required by the Italian law for death certification), ranging from 35 to 59 min. Among the 20 livers retrieved and 18 kidneys retrieved, 16 livers, and 11 kidneys (single kidney transplantation) were transplanted, after ex vivo reperfusion, respectively. CONCLUSIONS: The use of NRP mobile teams proved to be feasible and safe in the management of cDCD in peripheral hospitals. No complications were reported with NRP despite the advanced age of most cDCDs.


Assuntos
Preservação de Órgãos , Perfusão , Doadores de Tecidos , Obtenção de Tecidos e Órgãos , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Obtenção de Tecidos e Órgãos/organização & administração , Obtenção de Tecidos e Órgãos/métodos , Preservação de Órgãos/métodos , Itália , Perfusão/métodos , Idoso , Adulto , Doadores de Tecidos/provisão & distribuição , Seguimentos , Oxigenação por Membrana Extracorpórea , Prognóstico , Transplante de Rim , Transplante de Fígado , Sobrevivência de Enxerto , Coleta de Tecidos e Órgãos/métodos
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