Giant GIST of the mesocolon: report of a case.

UNLABELLED: Gastrointestinal stromal tumors are rare neoplasms arising from mesenchymal cells of the gastrointestinal tract, that strongly express a class III receptor tyrosine kinase, called KIT, due to some mutations in the KIT proto-oncogene. Two thirds of GISTs are found in the stomach, 20% to 50% in the small bowel (one third in the duodenum), and 5% to 15% in colon and rectum; GISTs, however, may rarely be found also in the oesophagus, omentum, mesentery or the retroperitoneum. Their treatment is strictly surgical, and only R0 resection can achieve good RESULTS: Treatment with Imatinib seems to be promising in case of unresectable or metastatic GIST, even if some trials are studying its effects after curative resection. GIST of the mesocolon are rare, and as in the other locations, require extensive surgery. The Autohrs report a case of giant malignant GIST arising from transverse mesocolon, treated by en-bloc resection of the tumor with a segment of transverse colon and great omentum.

[Synchronous lung cancer; clinical case of triple lung carcinoma]. / Cancro del polmone sincrono: caso clinico di triplice carcinoma polmonare.

The case of a 57-year-old man with three synchronous malignancies of the lung (adenocarcinoma, small cell carcinoma, squamous carcinoma in situ) is presented. This is one of the few cases reported in the literature with three different histologic types in the same pulmonary lobe.