Sex contextualism in laboratory research: Enhancing rigor and precision in the study of sex-related variables.

Understanding sex-related variation in health and illness requires rigorous and precise approaches to revealing underlying mechanisms. A first step is to recognize that sex is not in and of itself a causal mechanism; rather, it is a classification system comprising a set of categories, usually assigned according to a range of varying traits. Moving beyond sex as a system of classification to working with concrete and measurable sex-related variables is necessary for precision. Whether and how these sex-related variables matter-and what patterns of difference they contribute to-will vary in context-specific ways. Second, when researchers incorporate these sex-related variables into research designs, rigorous analytical methods are needed to allow strongly supported conclusions. Third, the interpretation and reporting of sex-related variation require care to ensure that basic and preclinical research advance health equity for all.

Gendering strategic action fields in sports governance.

How do meso-level field relations shape the ways that sports organizations act on gender equality? In this paper, we approach international sports governance as comprised of meso-level fields of strategic action in which male dominance and relations of masculinity are centrally at stake. We focus on the Union Cycliste Internationale (UCI), showing how the organization's efforts to address gender inequality are shaped by its relations with adjacent actors in the field. These actors jockey to form strategic coalitions as they struggle over the influence and resources to define the field configuration of international cycling, with challenges to the gendered status quo requiring careful management. Based on semi-structured interviews with individuals who held an elected or staff position within the UCI between 2005 and 2020, we show how field relations shaped the work of the UCI Women's Committee during this period as well as the experiences of women who succeeded in accessing decision-making roles. The UCI emerges in our analysis as a central governance unit via which the historical accumulation of advantage to men is preserved. We suggest that studying meso-level fields of strategic action can advance sociological research more broadly on how sports organizations are shaped by their contingent, dynamic, and (gender) unequal context.

Advancing feminist innovation in sport studies: A transdisciplinary dialogue on gender, health and wellbeing.

Athlete health and wellbeing requires a holistic, multidimensional approach to understanding, supporting, and treating individual athletes. Building more supportive, inclusive, and equitable environments for the health and wellbeing of women and gender expansive people further requires gender-responsive approaches that promote broader cultural change. Feminist sport and exercise medicine practitioners, sports scientists, and social science researchers are increasingly coming together in their efforts to do this work. However, working across disciplines inevitably includes an array of ontological, epistemological, and political challenges. In this paper, we offer a curated 'dialogue' with a group of feminist scholars engaged in research and practice across disciplines, bringing them together to discuss some of the most pressing gendered issues in sport today (i.e., ACL injury, concussion, menstruation in sport, mental health, gender categories). In so doing, we amplify the voices of those working (empirically and clinically) at the disciplinary intersections of gender, sport and health, and learn about some of the current and future possibilities for transdisciplinary innovations and strategies for building (responsiveness to) cultural change.

Lost in translation? Beyond sex as a biological variable in animal research.

In this article, I develop a feminist posthumanist account of biomedical policymaking as a material-discursive intervention that shapes the emergence of phenomena in the scientific laboratory. The setting is United States (U.S.) biomedicine, where a recent policy of the National Institutes of Health has mandated the consideration of sex in basic and preclinical research. Called Sex as a Biological Variable (SABV), the mandate configures cell lines and animal models as the next frontier in the project of advancing gender equity in biomedical research. Given sex and gender are increasingly recognised as having complex, entangled, and dynamic effects on human health and illness, how do laboratory animals respond to their attempted enrolment in this regulatory intervention? Through a qualitative analysis of this policy domain, I show how laboratory animals reveal the context-specific character of sex, its multiplicity and elusiveness as a so-called biological variable, and the considerable work needed to shore up human ideologies of sex as a pervasive cross-species form of binary difference. I suggest that while regulatory interventions constrain patterns of mattering, they also serve as agential openings in which laboratory animals can 'kick back' and reconfigure the pursuit of knowledge, particularly as it relates to difference and health.

Co-production, multiplied: Enactments of sex as a biological variable in US biomedicine.

In 2016 the US National Institutes of Health introduced a policy mandating consideration of Sex as a Biological Variable (SABV) in preclinical research. In this article, I ask what, precisely, is meant by the designation of sex as a 'biological variable', and how has its inclusion come to take the form of a policy mandate? Given the well documented complexity of 'sex' and the degree to which it is politically and scientifically contested, its enactment via policy as a biological variable is not a given. I explore how sex is multiply enacted in efforts to legitimate and realize the SABV policy and consider how the analytical lens of co-production sheds light on how and why this occurs. I show that the policy works to reassert scientific and political order by addressing two institutional concerns: the so-called reproducibility crisis in preclinical research, and pervasive gender inequality across the institution of biomedicine. From here, the entity that underpins this effort - sex as a biological variable - becomes more than one thing, with enactments ranging from an assigned category, to an outcome, to a causal biological force in its own right. Sex emerges as simultaneously entangled with yet distinct from gender, and binary (female/male) yet complex in its variation. I suggest that it is in the very attempt to delineate natural from social order, and in the process create the conditions to privilege a particular kind of science and account of embodied difference, that ontological multiplicity becomes readily visible. That this multiplicity goes unrecognized points to the unifying role of an overarching ideological commitment to sex as a presumed binary and biological scientific object, the institutional dominance of which is never guaranteed.