[Single dose of antibiotic prophylaxis in elective cesarean sections].

INTRODUCTION: The aim of our study was to determine whether a single-dose preoperative administration of antibiotics was sufficient to prevent intra and postoperative infections in the parturients without a high risk of developing an infection, in whom the delivery was completed by cesarean section, as well as to answer whether the administered dose of antibiotics satisfied the requirements of therapeutic concentrations necessary to protect against infection in the period during the surgical procedure and during the first 6 postoperative hours. MATERIAL AND METHODS: All investigated pregnant women were planned to have elective cesarean section as a mode of delivery. They were distributed in groups depending on the type (cephalexin, gentamycin and cephazolin) of antibiotic prophylaxis administered as a single dose. In all patients the clinical postoperative course was followed for possible infection. The concentrations of antibiotics were estimated immediately and 6 h following the operation. The estimation of antibiotic concentrations was done by the method of liquid chromatography (for antibiotics belonging to the group of cephalosporins), i.e. RIA method for antibiotics from the group of aminoglycosides. RESULTS AND CONCLUSION: The total number of infections in investigated groups was 5.18%. The measured mean concentrations of administered antibiotics following the operation and 6 h later were above MIC. This is a proof that the obtained antibiotic prophylaxis by a single dose administration of anbtibiotic is sufficient to prevent the invasion of pathogenic microorganisms from the skin.

[The history and development of obstetrics and gynecology services in Vrbas].

INTRODUCTION: This is a brief historical review of the development of the town of Vrbas, of the Obstetrics and Gynecology Department in the town's hospital. FIRST EDUCATED GYNECOLOGIST IN VRBAS: This paper provides detailed description of the development of the Obstetrics and Gynecology Department which dates back to 1945, when the first educated professionals (the midwifes and doctors) came to Vrbas. A great contribution to the development of the Department was made by doctor Zoran Radivojevic, (gynecologist) in 1959, when he was appointed Chief of the Department. WOMEN'S HEALTH CENTERS: This paper also presents the development of the women's health centers in Vrbas. Obstetrics and Gynecology Department was part of the hospital surgery department and at the beginning it was under the supervision of surgeons. However, later on, it was separated fom the surgery and became an independent department. Today, the Obstetrics and Gynecology Department in Vrbas is located in the General Hospital and it is a modern and well equipped health facility. All women from the municipalitY of Vrbas and this region use the services of this department.