[Importance of the qualitative composition of dietary proteins in the dietotherapy of ischemic heart disease patients]. / Znachenie kachestvennogo sostava pishchevykh belkov v dietoterapii bol'nykh ishemicheskoi bolezn'iu serdtsa.

The effects of two isocaloric antiatherosclerotic diets (containing 120 g protein) differing in the amino acid composition of protein sources introduced were studied and compared in patients with coronary heart disease. Conventional protein sources were used in the first diet, whereas in the second diet, 15% of protein (by weight) was replaced by soybean protein isolate. A study was also made of the effect of dietetic management on lipid metabolism in blood serum. Hemocoagulation, capillary permeability, the kallikrein-kinin system, and immune responsiveness. An increase in the hypolipidemic effect of the diet was noted together with a decrease in the activity of the kallikrein-kinin system, capillary permeability, and body autosensitization upon introduction into the diet of soybean protein isolate. The increase of the protein quota as well as that attained by means of introducing in the diet of soybean protein isolate reduces the therapeutic effect of the diet on hemostasis.

[Effect of dietotherapy on the magnesium content of the blood serum of ischemic heart disease patients]. / Vliianie dietoterapii na soderzhanie magniia v syvorotke krovi bol'nykh ishemicheskoi bolezn'iu serdtsa.

Examination of patients with chronic coronary heart disease who suffered myocardial infarction has shown that most of them had a high blood serum content of magnesium. The magnesium content was lowered in 25% of the examined and was maximal in serum of the patients under 40 years. A positive correlation of the magnesium content to the serum content of beta-cholesterol and a negative one to the content of pre-beta-cholesterol and triglycerides were noted. After dietetic management a tendency was observed toward a 24% decrease in the magnesium content in obese patients and a 20% decrease in patients with normal body weight. Both groups demonstrated a reduction (but within normal) in the high magnesium content and a moderate elevation of the initially lowered content. The measurement of the magnesium content in blood serum cannot be regarded as an informative enough test for revealing the role of magnesium in the pathogenesis of coronary heart disease.

[Value of using dietary factors in the prevention and treatment of ischemic heart disease]. / Znachenie primeneniia alimentarnogo faktora v pofilaktike i lechenii ishemicheskoi bolezni serdtsa.

Influence of differentiated use of the alimentary factors on the lipemia level, hemocoagulation activity, arterial pressure level, carbohydrate tolerance and catecholamine content in the blood plasma of CHD patients was shown under the conditions of controlled dietotherapy. Incorporation of diet in multimodality therapy and prevention of this disease under inpatient, sanatorium-prophylactic and outpatient conditions was emphasized.

[Effect of diet therapy on indices of the activity of the plasma kallikrein-kinin system of young and middle-aged ischemic heart disease patients]. / Vliianie dietoterapii na pokazateli aktivnosti kallikrein-kininovoi sistemy plazmy krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa molodogo i srednego vozrasta.

Young and middle-aged patients with coronary heart disease manifested an increase in the activity of kallikrein and BAEE-esterase together with a reduction in the levels of prekallikrein and alpha 2-macroglobulin. The maximal shifts were seen in young patients and in patients who sustained myocardial infarction less than a year before examination. High kallikrein level was associated with hypertriglyceridemia and disordered fibrinolytic activity. Dietetics promoted the normalization of the disordered parameters, particularly in patients whose diet included soybean.

[Status of the kallikrein-kinin system of the blood in young and middle-aged patients with ischemic heart disease]. / O sostoianii kallikrein-kininovoi sistemy krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa molodogo i srednego vozrasta.

Increase in BAEE-esterase and kallikrein activities, simultaneously with decrease in alpha 2-macroglobulin and prekallikrein activities were found in blood plasma of young and middle age patients with heart ischemic disease. The maximal alterations were observed in young patients as well as in patients, subjected to heart infarction less than a year before the examination. Maximal activity of kallikrein was accompanied by deterioration of fibrinolytic activity, by hypertriglyceridemia and by increase in adrenaline excretion. Dietetics normalized partially the state of kallikrein-kinin system, especially, in patients ration of which contained soybean products.

[Comparative evaluation of the role of protein in the diet therapy of ischemic heart disease and rheumatism with a slight degree of activity]. / Sravnitel'naia otsenka roli belka v dietoterapil boly'nykh ishemicheskoi bolezn'iu serdtsa i revmatizmom s maloi stepen'iu aktivnosti protsessa.

The patients with chronic heart disease (265 subjects) and with little active rheumatic fever (145 subjects) received two variants of isocaloric diets which differed only in protein quota. The former diet contained the physiological norm of protein (100 g) and the latter one a higher quota (130 g). As a result of the treatment the subjective sensations and objective status of all the patients improved. Evaluation of the time course of lipid metabolism, the system of hemostasis, capillary permeability and immunological reactivity showed that the diet containing the physiological norm of protein appeared the most effective in patients with ischemic heart disease, whereas that with a higher protein quota turned out the most adequate in patients with rheumatic fever.

[Effect of a reducing diet on metabolic disorders in ischemic heart disease patients having excess weight]. / Vliianie redutsirovannoi diety na nekotorye metabolicheskie narusheniia u bol'nykh ishemicheskoi bolezn'iu serdtsa, imeiushchikh izbytochnuiu massu.

The paper concerns the effect of the diet with a strongly reduced content of carbohydrates, with a restriction of table salt and extractive substances on lipid and carbohydrate metabolism, on catecholamine secretion and exocrine pancreatic function in patients with ischemic heart disease accompanied by overweight and disturbed carbohydrate tolerance. Dietetics has a normalizing action on the body overweight, lipid composition and lipoproteid spectrum, as well as on the enhanced activity of serum trypsin. Moreover, it makes the blood content of immunoreactive insulin return partially to normal.

[Effect of diets with a varying protein content on fibrinolysis in ischemic heart disease]. / Vliianie diet s razlichnym soderzhaniem belka na fibrinoliz u bol'nykh ishemicheskoi bolezn'iu serdtsa.

A comparative influence of an antiatherosclerotic diet with a reduced proportion of protein (65--70 g) and of a diet with an amount of protein in line with the physiological standard (100--110 g) on the fibrinolysis and lipids spectrum of the blood was studied in 60 patients with ischemic heart disease. The antiatherosclerotic diet is shown to have most favourable effect both on the fibrinolytic system and on the lipids metabolism with the protein proportion of 100--110 g, i.e. in keeping with the physiological standards. A reduction of the protein content in the diet of patients with ischemic heart disease lowers the effect of treatment and does not have any positive influence on the function of the fibrinolytic system.

[Excretion of catecholamines and DOPA in lipid metabolism disorders]. / Ekskretsiia katekholaminov i DOFA pri narusheniiakh metabolizma lipidov.

Excretion of catecholamines and DOPA was impaired in patients with metabolic-alimentary obesity, with ischemic disease of heart, with atherosclerosis and excessive weight. Distinct decrease in content of adrenaline, noradrenaline and DOPA was observed in patients with obesity; the phenomenon was less pronounced in ischemic disease of heart, mainly in aged patients. Correlation was found between the rate of excretion of catecholamines and DOPA and the extent of hyperlipidemia. Dietetics did not normalize completely the impairments studied. Additional administration of pyridoxine caused a favorable effect.

[Effect of an anti-atherosclerotic diet with different protein content on catecholamine and DOPA excretion in patients with ischemic heart disease and excess weight]. / Vliianie protivoateroskleroticheskoi diety s razlichnym soderzhaniem belka na ékskretsiiu katekholaminov i DOFA u bol'nykh ishemicheskoi bolezn'iu serdtsa s izbytochnya vesom.

In patients with ischemic heart disease (IHD) with excess body weight the excretion of catecholamines and DOPA was investigated. In patients of middle and advanced age the excretion of norepinephrine was found to be down, while in those of the young age the excretion of epinephrine and norepinephrine proved to be up. There exist a correlation between the rising level of norepinephrine and hyperlipidemia. In patients with IHD the blood serotonin content is elevated. The use of an antiatherosclerotic diet with a higher protein content tends to bring down the level of the norepinephrine and, partially, also of epinephrine excretion. With patients kept on an antiatherosclerotic diet with protein content the excretion of norepinephrine sharply decreases and that of epinephrine rises. Administration of pyridoxine superimposed upon dietary variants acts favorably on the catecholamines excretion. Under the effect of the diets in question the blood serotonin remains unchanged. The implication is that both the high- and low-protein quotas in the composition of antiatherosclerotic diets do not produce an optimal effect on the catecholamines and DOPA metabolism in patients with IHD and an excess body weight.

[Influence of an anti-atherosclerotic diet containing a protein enricher on the clinico-biochemical indices of patients with ischemic heart disease]. / Vliianie protivoateroskleroticheskoi diety, soderzhashchei belkovyi obogatitel', na kliniko-biokhimicheskie pokazateli bol'nykh ishemicheskoi bolezn'iu serdtsa.

Observations covered two groups of patients with ischemic heart disease (IHD). The first, control group (50 patients) received a course of treatment with antiatherosclerotic diet, while the second (50) was kept on a curative diet that included a protein enrichment agent. It was found that the patients of the lastly named group demonstrated, along with an improved general condition and diminution of basic clinical manifestation of IHD, a more noticeable fall of all the lipid fractions and also a more distinct and significant reduction of an elevated permeability of the capillaries to protein. The results obtained justify recommending inclusion of the protein enrichment agent in the diet of patients with IHD, to increase the biological value of the ration and the effect of the ongoing dietotherapy.