Psychological Impact of TP53-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort.

Counselling and genetic testing (CGT) after neonatal screening may increase depression and anxiety (DA) levels during cancer surveillance. This study assessed the DA scores in mothers of newborns from Paraná state, Southern Brazil, carrying the TP53 p.R337H variant. To understand and adjust DA conditions during term of pregnancy, we initially detected sociodemographic covariates [marital status (MS), number of children (NC), and/or education level (EL): MS-NC-EL] on an independent group of pregnant women (not subjected to genetic testing). The Hospital Anxiety and Depression Scale (HADS) was used to assess risk factors in pregnant (cross-sectional analysis) and unrelated mothers (at 2-month intervals, longitudinal study) of TP53 p.R337H-tested newborns (three sessions of HADS analysis) using Wilcoxon (Mann-Whitney) and Kruskal-Wallis nonparametric tests. Lower anxiety levels were observed in mothers of noncarriers (without MS-NC-EL = 6.91 ± 1.19; with MS-NC-EL = 6.82 ± 0.93) than in mothers of p.R337H carriers in the first session (without MS-NC-EL = 6.82 = 8.49 ± 0.6025, with MS-NC-EL = 6.82 = 9.21 ± 0.66). The anxiety levels significantly decreased 4 months after CGT (third session) in mothers of p.R337H carriers. We did not find a significant change in depression scores. Mothers with mental health instability requiring medications need periodical psychological support during and after CGT.

Efeito da clorexidina com carbonato de cálcio no tratamento da mucosite em crianças com neoplasias malignas / The effect of chlorhexidine plus calcium carbonate for treatment of mucositis in children with malignant disease

Objetivo: Determinar a eficácia da pasta clorexidina com carbonato de cálcio no tratamento da mucosite de crianças com neoplasias malignas. Métodos: foram selecionados dois grupos de pacientes com neoplasias malignas que apresentaram mucosite oral durante a internação, em dois hospitais de referência, entre outubro de 2002 e janeirode 2004. O grupo A, com 9 casos foi tratado com pasta de carbonato de cálcio / Objective: to determine the efficacy of chloorhexidine plus calcium carbonate in children with malignant disease that developed oral mucositis. Methods: twenty-three inpatients with malignant disease and oral mucositis from two reference hospitals were analyzed from October 2002 to January 2004...

Expressão dos marcadores mielóides e prognóstico das leucemias / myeloid markers expression and prognosis of acute lymphoid leukemia

Objetivos: avaliar os marcadores mielóides positivos como fator de risco para a sobrevida livre de doença e mortalidade em crianças com leucemia linfóide aguda. Casuística e métodos: d=foram revisados 84 prontuários de crianças com leucemia linfóide aguda do Hospital Pequeno Princípe de Curitiva, PR ...