RESUMO
Vibrio fluvialis is a Gram-negative, oxidase-producing, halophilic bacterium that, as a pathogen, has been implicated mainly as a cause of gastroenteritis. We describe a case of V. fluvialis peritonitis after a traffic accident that is, to our knowledge, the 1st report of non-continuous ambulatory peritoneal dialysis-related acute peritonitis caused by this organism.
Assuntos
Peritonite/microbiologia , Vibrioses/microbiologia , Vibrio/isolamento & purificação , Acidentes de Trânsito , Doença Aguda , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Evolução Fatal , Feminino , Humanos , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Peritonite/tratamento farmacológico , Vibrio/classificação , Vibrio/efeitos dos fármacos , Vibrio/genética , Vibrioses/tratamento farmacológicoRESUMO
BACKGROUND AND AIM: Based on our previous studies that Artemisia asiatica extracts exert either antioxidative or cytoprotective actions against non-steroidal anti-inflammatory drugs or Helicobacter pylori-induced gastric mucosal injury, or imposes qualified ulcer healing in an acetic acid-induced gastric ulcer model, we investigated the protective effects of Artemisia asiatica extracts against ethanol-induced gastric mucosal injury. METHODS: Sprague-Dawley rats received 4 g/kg body weight (BW) of absolute ethanol intragastrically, which produced visible hemorrhagic gastric lesions 60 min later. RESULTS: In this animal setting, the pretreatment of Artemisia extracts (30 or 100 mg/kg BW), 1 h before ethanol administration, significantly attenuated the source of gastric injury, which was assessed with gross and microscopic analysis (P < 0.01). Protection from alcohol-induced damage with Artemisia pretreatment was associated with significantly decreased lipid peroxidation, protecting gastric mucosa from glutathione depletion, as well as the inhibition of the cytochrome 2E1 ethanol-metabolizing enzyme. It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates. CONCLUSION: The data suggest that the ethanol extracts of Artemisia asiatica exerted significant protection from alcohol-induced gastric mucosal injury through bio-regulation, which is essential for cytoprotection and anti-inflammation.
