RESUMO
The paper presents the results of a retrospective analysis of the chemoradiotherapy of 393 infant patients with Hodgkin's disease.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doença de Hodgkin/tratamento farmacológico , Doença de Hodgkin/radioterapia , Adolescente , Adulto , Quimioterapia Adjuvante/efeitos adversos , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Masculino , Segunda Neoplasia Primária/etiologia , Dosagem Radioterapêutica , Radioterapia Adjuvante/efeitos adversos , Estudos Retrospectivos , Análise de Sobrevida , Resultado do Tratamento , Adulto JovemAssuntos
Doença de Hodgkin/radioterapia , Adolescente , Adulto , Fatores Etários , Amenorreia/diagnóstico por imagem , Pré-Escolar , Radioisótopos de Cobalto/uso terapêutico , Europa (Continente) , Feminino , Humanos , Estudos Multicêntricos como Assunto , Recidiva Local de Neoplasia , Cintilografia , Radioterapia/efeitos adversos , Dosagem Radioterapêutica , Ensaios Clínicos Controlados Aleatórios como Assunto , Fatores de Risco , Federação Russa , Fatores de TempoRESUMO
Radiation or chemoradiation therapy was performed in 97 children with diffusely growing brainstem tumors. A reduction in the severity of neurological disorders was achieved in 92 (94.8%) patients. The course of the disease was traced in 79 patients. Control studies recorded no complete tumor regression. Following 4-8 months, there was growth resumption of a tumor with its lysis and cyst formation in most children. The principal cause of death was local tumor progression. Six-month survivors were 64 (81%) patients; one-, two-, and three-survivors were 21 (26.5%), 8 (10.1%), and 3 (7.65) patients, respectively; one (2.8%) patient survived 5 years. A combination of radiotherapy and monochemotherapy with temodal, vincristine, oncofer, and theraloc failed to improve immediate and long-term results
Assuntos
Neoplasias do Tronco Encefálico/terapia , Anticorpos Monoclonais/uso terapêutico , Anticorpos Monoclonais Humanizados , Antineoplásicos/uso terapêutico , Neoplasias do Tronco Encefálico/tratamento farmacológico , Neoplasias do Tronco Encefálico/mortalidade , Neoplasias do Tronco Encefálico/radioterapia , Quimioterapia Adjuvante , Criança , Dacarbazina/análogos & derivados , Dacarbazina/uso terapêutico , Progressão da Doença , Humanos , Temozolomida , Resultado do Tratamento , Vincristina/uso terapêuticoRESUMO
The incidence of secondary malignancies (SM) was studied in a population of 219 patients in late periods (3-29 years) after childhood and adolescence chemoradiotherapy for Hodgkin's lymphoma (HL). SMs were found in 15 (6.8%) patients. These were solid neoplasms located in the irradiated areas in 12 of them, including 4 patients with thyroid cancer and 2 with gastric cancer. All 3 cases of acute leukemia had occurred after chemoradiotherapy performed by extended programs that consisted of a large number of chemotherapy cycles. The detection rate of SM did not significantly depend on the dose of radiation, age at start of treatment, and a child's gender. The findings suggest that there is a need for the maximum concentration of an irradiation beam in the area of thyroid lesion and exposure, for limited cytotoxic therapy programs, and lifetime medical observation of the patients treated for HL in childhood.
Assuntos
Doença de Hodgkin/terapia , Neoplasias Induzidas por Radiação/epidemiologia , Segunda Neoplasia Primária/epidemiologia , Adolescente , Criança , Pré-Escolar , Relação Dose-Resposta à Radiação , Feminino , Doença de Hodgkin/tratamento farmacológico , Doença de Hodgkin/radioterapia , Humanos , Incidência , Masculino , Neoplasias Induzidas por Radiação/prevenção & controle , Segunda Neoplasia Primária/prevenção & controleAssuntos
Doença de Hodgkin/radioterapia , Neoplasias Induzidas por Radiação/epidemiologia , Neoplasias da Glândula Tireoide/epidemiologia , Adulto , Criança , Relação Dose-Resposta à Radiação , Feminino , Humanos , Masculino , Neoplasias Induzidas por Radiação/etiologia , Fatores de Risco , Fatores Sexuais , Neoplasias da Glândula Tireoide/etiologia , Nódulo da Glândula Tireoide/epidemiologia , Nódulo da Glândula Tireoide/etiologiaRESUMO
Out of 108 children with brain tumors, aged 3-15, receiving radiotherapy in 191-1997, cerebral medulloblastoma was identified in 37 (34%). After total or subtotal excision of tumor, the latter were given 4-12 cycles of polychemotherapy. The brain and spinal marrow was exposed to 30-35 Gy followed by aiming 50-55 Gy irradiation of posterior cranial fossa. Three patients received radiation for recurrent tumor. One patient suffered demyelination as complication after repeated exposure. Out of 32 follow-up patients, 19 have survived an average of 33 months while 13 died having survived an average of 21 months. The main causes of failed therapy proved local progression of tumor and dissemination via liquor. Radical extent of surgery was used as the main prognostic factor.
Assuntos
Neoplasias Cerebelares/radioterapia , Meduloblastoma/radioterapia , Adolescente , Neoplasias Encefálicas/radioterapia , Neoplasias Cerebelares/cirurgia , Criança , Pré-Escolar , Progressão da Doença , Feminino , Germinoma/radioterapia , Glioma/radioterapia , Humanos , Masculino , Meduloblastoma/cirurgia , Recidiva Local de Neoplasia/radioterapia , Tumores Neuroectodérmicos/radioterapia , Dosagem Radioterapêutica , Radioterapia Adjuvante , Análise de Sobrevida , Resultado do TratamentoRESUMO
The efficacy of combined treatment of 176 children of different age has been analyzed. All the children suffered from Hodgkin's disease which was treated according to protocols COPP, MOPP, DVPP, +radiotherapy, maintenance chemotherapy. The response to the treatment got worse at the age of prepuberty and puberty, e. g. younger children had recurrences in 19.2% of the cases, adolescents had in 33.3%. The latter more frequently died of the malignancy progression. It is concluded that children older than 13 years are at greater risk of bad Hodgkin's disease outcomes and need more intensive treatment programs.