Human radiation for medicine, spiritism and hypnosis in Argentina: scientific controversies around vital radiations (1880-1930).

In the mid-nineteenth century, magnetic theories penetrated other recognized medical practices in Argentina in order to rationalize their procedures, in a culture that accepted and validated magnetism as a positive science. At the start of the twentieth century, mesmerists created a society, published books and journals, and carried out a large welfare programme; there were public lectures, and magnetic treatment for spiritualists and the general public, emphasizing the therapeutic properties of mesmerism. Magnetologists/mesmerists measured vital radiation and built devices using sensitive objects as 'physical' evidence of it. There was an interest in acquiring and using artefacts to measure human radiation useful in medicine. Magnetic practices survived until the end of the 1920s, when they lost importance.

[Multiple endocrine neoplasia and very early onset inflammatory bowel disease. An unexpected association]. / Neoplasia endócrina múltiple y enfermedad inflamatoria intestinal de inicio muy temprano. Una asociación inesperada.

Very early onset inflammatory bowel disease (VEOIBD) is a rare entity in pediatrics. Its association with primary immunodeficiencies of monogenic origin is known. We present the case of a patient diagnosed with VEOIBD who underwent massive paralleled exome sequencing. The result of the study showed a pathogenic variant in the RET proto-oncogene, associated with multiple endocrine neoplasia type 2A disease. There are no previous reports of association of RET proto-oncogene variants with VEOIBD. The presence of these two clinical entities cannot be attributed to a single genetic cause.

La enfermedad inflamatoria intestinal de inicio muy temprano (VEOIBD) es una entidad rara en pediatría. Es conocida su asociación con inmunodeficiencias primarias de origen monogénico. Presentamos el caso de una paciente con diagnóstico de VEOIBD a quien se le realizó una secuenciación masiva del exoma. El resultado del estudio permitió identificar una variante patogénica en el proto oncogen RET, asociada con enfermedad neoplasia endocrina múltiple tipo 2A. No hay reportes de asociación de variantes en el proto oncogen RET con VEOIBD. No se puede adjudicar la presencia de estas dos entidades clínicas a una única causa genética.

Genetic and phenotypic findings in 34 novel Spanish patients with DDX3X neurodevelopmental disorder.

DDX3X is a multifunctional ATP-dependent RNA helicase involved in several processes of RNA metabolism and in other biological pathways such as cell cycle control, innate immunity, apoptosis and tumorigenesis. Variants in DDX3X have been associated with a developmental disorder named intellectual developmental disorder, X-linked syndromic, Snijders Blok type (MRXSSB, MIM #300958) or DDX3X neurodevelopmental disorder (DDX3X-NDD). DDX3X-NDD is mainly characterized by intellectual disability, brain abnormalities, hypotonia and behavioral problems. Other common findings include gastrointestinal abnormalities, abnormal gait, speech delay and microcephaly. DDX3X-NDD is predominantly found in females who carry de novo variants in DDX3X. However, hemizygous pathogenic DDX3X variants have been also found in males who inherited their variants from unaffected mothers. To date, more than 200 patients have been reported in the literature. Here, we describe 34 new patients with a variant in DDX3X and reviewed 200 additional patients previously reported in the literature. This article describes 34 additional patients to those already reported, contributing with 25 novel variants and a deep phenotypic characterization. A clinical review of our cohort of DDX3X-NDD patients is performed comparing them to those previously published.

Development and Validation of a New Method for Detecting Acetic Bacteria in Wine.

In winemaking, excessive production of acetic acid by acetic acid bacteria poses a major challenge, leading to rejection of wine by consumers. The aim of this study was to devise an economically viable and easy-to-use liquid culture medium for the preventive detection of microorganisms capable of generating acetic acid in wine. The modified medium incorporated specific nutrients that favored the growth of acetic acid bacteria and increased selectivity. Under varying conditions and with different types of wine, this medium was tested together with inoculated samples, comparing the occurrence of acetic acid and olfaction. The result was a new liquid medium based on olfactometry, designed to facilitate its use in wineries, even by untrained personnel and without the need for complex laboratory equipment. Validation was carried out on a variety of wines, determining the onset of the presence of acetic acid in the medium. This innovative culture medium provides a means to estimate the concentration of micro-organisms capable of producing acetic acid in wine. Its application in wineries facilitates proactive decision making, avoiding undesirable increases in acetic acid concentration.

Seven Additional Patients with SOX17 Related Pulmonary Arterial Hypertension and Review of the Literature.

Pulmonary arterial hypertension (PAH) is an infrequent disorder characterized by high blood pressure in the pulmonary arteries. It may lead to premature death or the requirement for lung and/or heart transplantation. Genetics plays an important and increasing role in the diagnosis of PAH. Here, we report seven additional patients with variants in SOX17 and a review of sixty previously described patients in the literature. Patients described in this study suffered with additional conditions including large septal defects, as described by other groups. Collectively, sixty-seven PAH patients have been reported so far with variants in SOX17, including missense and loss-of-function (LoF) variants. The majority of the loss-of-function variants found in SOX17 were detected in the last exon of the gene. Meanwhile, most missense variants were located within exon one, suggesting a probable tolerated change at the amino terminal part of the protein. In addition, we reported two idiopathic PAH patients presenting with the same variant previously detected in five patients by other studies, suggesting a possible hot spot. Research conducted on PAH associated with congenital heart disease (CHD) indicated that variants in SOX17 might be particularly prevalent in this subgroup, as two out of our seven additional patients presented with CHD. Further research is still necessary to clarify the precise association between the biological pathway of SOX17 and the development of PAH.

Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.

Snijders Blok-Campeau syndrome (SNIBCPS, OMIM# 618205) is an extremely infrequent disease with only approximately 60 cases reported so far. SNIBCPS belongs to the group of neurodevelopmental disorders (NDDs). Clinical features of patients with SNIBCPS include global developmental delay, intellectual disability, speech and language difficulties and behavioral disorders like autism spectrum disorder. In addition, patients with SNIBCPS exhibit typical dysmorphic features including macrocephaly, hypertelorism, sparse eyebrows, broad forehead, prominent nose and pointed chin. The severity of the neurological effects as well as the presence of other features is variable among subjects. SNIBCPS is caused likely by pathogenic and pathogenic variants in CHD3 (Chromodomain Helicase DNA Binding Protein 3), which seems to be involved in chromatin remodeling by deacetylating histones. Here, we report 20 additional patients with clinical features compatible with SNIBCPS from 17 unrelated families with confirmed likely pathogenic/pathogenic variants in CHD3. Patients were analyzed by whole exome sequencing and segregation studies were performed by Sanger sequencing. Patients in this study showed different pathogenic variants affecting several functional domains of the protein. Additionally, none of the variants described here were reported in control population databases, and most computational predictors suggest that they are deleterious. The most common clinical features of the whole cohort of patients are global developmental delay (98%) and speech disorder/delay (92%). Other frequent features (51-74%) include intellectual disability, hypotonia, hypertelorism, abnormality of vision, macrocephaly and prominent forehead, among others. This study expands the number of individuals with confirmed SNIBCPS due to pathogenic or likely pathogenic variants in CHD3. Furthermore, we add evidence of the importance of the application of massive parallel sequencing for NDD patients for whom the clinical diagnosis might be challenging and where deep phenotyping is extremely useful to accurately manage and follow up the patients.

Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.

Lamb-Shaffer Syndrome (LSS; OMIM #616803; ORPHA #313892; ORPHA #313884) is an infrequent genetic disorder that affects multiple aspects of human development especially those related to the development of the nervous system. LSS is caused by variants in the SOX5 gene. At the molecular level, SOX5 gene encodes for a transcription factor containing a High Mobility Group (HMG) DNA-Binding domain with relevant functions in brain development in different vertebrate species. Clinical features of Lamb-Shaffer syndrome may include intellectual disability, delayed speech and language development, attention deficits, hyperactivity, autism spectrum disorder, visual problems and seizures. Additionally, patients with the syndrome may present distinct facial dimorphism such as a wide mouth with full lips, small chin, broad nasal bridge, and deep-set eyes. Other physical features that have been reported in some patients include short stature, scoliosis, and joint hypermobility. Here, we report the clinical and molecular characterization of a Spanish LSS cohort of new 20 patients and review all the patients published so far which amount for 111 patients. The most frequent features included developmental delay, intellectual disability, visual problems, poor speech development and facial dysmorphic features. Strikingly, pain insensitivity and hypermetropia seems to be more frequent than previously reported, based on the frequency seen in the Spanish cohort. Eighty-three variants have been reported so far, single nucleotide variants (SNV) and copy number variants represent 47% and 53%, respectively, from the total of variants reported. Similarly to previous reports, the majority of the SNVs variants of the novel patients reported herein fall in the HMG domain of the protein. However, new variants, affecting other functional domains, were also detected. In conclusion, LLS is a rare genetic disorder mostly characterized by a wide range of developmental and neurological symptoms. Early diagnosis would allow to start of care programs, clinical follow up, prospective studies and appropriate genetic counseling, to promote clinical and social improvement to have profound lifelong benefits for patients and their families. Further research is needed to better understand the underlying mechanisms of the syndrome related to SOX5 haploinsufficiency.

Lobular Endocervical Glandular Hyperplasia, a mimicker and potential pitfall for HPV-independent well differentiated Gastric-type Endocervical Adenocarcinoma: Case report and literature review focusing on histology, immunophenotype, and molecular findings.

Lobular glandular endocervical hyperplasia is an uncommon benign entity within the spectrum of gastric-type endocervical lesions. We report a case of a 48-year-old woman who presented with a palpable mass and watery vaginal discharge. Ultrasound revealed an 8 cm × 4 cm × 3 cm multicystic mass affecting the cervix, and hysterectomy was performed. The well-delimited multicystic, mucinous mass distorted the entire cervix. Microscopically, endocervical glandular proliferation with a lobular architecture was observed. The glands were lined with a single layer of tall, mucin-rich, columnar cells with basal and bland nuclei. The lesion was positive for MUC6 marker and hormonal receptors were negative, while P53 expression was normal. Three years later, the patient remained disease free. Here, we discuss the differential diagnosis between lobular glandular endocervical hyperplasia and similar conditions, particularly gastric-type endocervical adenocarcinoma, and review the literature focusing on the molecular pathways underlying gastric-type endocervical lesions. This case highlights the importance of accurate diagnosis to ensure favorable outcomes.

Clinical Heterogeneity and Different Phenotypes in Patients with SETD2 Variants: 18 New Patients and Review of the Literature.

SETD2 belongs to the family of histone methyltransferase proteins and has been associated with three nosologically distinct entities with different clinical and molecular features: Luscan-Lumish syndrome (LLS), intellectual developmental disorder, autosomal dominant 70 (MRD70), and Rabin-Pappas syndrome (RAPAS). LLS [MIM #616831] is an overgrowth disorder with multisystem involvement including intellectual disability, speech delay, autism spectrum disorder (ASD), macrocephaly, tall stature, and motor delay. RAPAS [MIM #6201551] is a recently reported multisystemic disorder characterized by severely impaired global and intellectual development, hypotonia, feeding difficulties with failure to thrive, microcephaly, and dysmorphic facial features. Other neurologic findings may include seizures, hearing loss, ophthalmologic defects, and brain imaging abnormalities. There is variable involvement of other organ systems, including skeletal, genitourinary, cardiac, and potentially endocrine. Three patients who carried the missense variant p.Arg1740Gln in SETD2 were reported with a moderately impaired intellectual disability, speech difficulties, and behavioral abnormalities. More variable findings included hypotonia and dysmorphic features. Due to the differences with the two previous phenotypes, this association was then named intellectual developmental disorder, autosomal dominant 70 [MIM 620157]. These three disorders seem to be allelic and are caused either by loss-of-function, gain-of-function, or missense variants in the SETD2 gene. Here we describe 18 new patients with variants in SETD2, most of them with the LLS phenotype, and reviewed 33 additional patients with variants in SETD2 that have been previously reported in the scientific literature. This article offers an expansion of the number of reported individuals with LLS and highlights the clinical features and the similarities and differences among the three phenotypes associated with SETD2.

Adult experiences in Beckwith-Wiedemann syndrome.

Beckwith-Wiedemann syndrome (BWS) is an overgrowth and epigenetic disorder caused by changes on chromosome 11p15. The primary features requiring management in childhood include macroglossia, omphalocele, lateralized overgrowth, hyperinsulinism, and embryonal tumors. Management guidelines have not been developed for adults with BWS and there have been few studies to assess the clinical needs of these patients. Furthermore, there have been few studies on the psychosocial implications of BWS in children or adults. Here, we present a descriptive summary of data gathered from two separate adult BWS cohorts. The first, a patient-based survey cohort, includes self-reported health information and recollections about BWS experiences, while the second provides results of a medical record-based assessment from patients in an overgrowth registry. Results highlight the clinical features and medical issues affecting two large independent cohorts of adults with BWS while noting similarities. Open-ended questions asked of the survey cohort yielded themes to guide future qualitative studies. Finally, the study demonstrated the reliability of patient-reported data and the utility of international partnerships in this context.

Clinical Spectrum and Tumour Risk Analysis in Patients with Beckwith-Wiedemann Syndrome Due to CDKN1C Pathogenic Variants.

Beckwith-Wiedemann syndrome spectrum (BWSp) is an overgrowth disorder caused by imprinting or genetic alterations at the 11p15.5 locus. Clinical features include overgrowth, macroglossia, neonatal hypoglycaemia, omphalocele, hemihyperplasia, cleft palate, and increased neoplasm incidence. The most common molecular defect observed is hypomethylation at the imprinting centre 2 (KCNQ1OT1:TSS DMR) in the maternal allele, which accounts for approximately 60% of cases, although CDKN1C pathogenic variants have been reported in 5-10% of patients, with a higher incidence in familial cases. In this study, we examined the clinical and molecular features of all cases of BWSp identified by the Spanish Overgrowth Registry Initiative with pathogenic or likely pathogenic CDKN1C variants, ascertained by Sanger sequencing or next-generation sequencing, with special focus on the neoplasm incidence, given that there is scarce knowledge of this feature in CDKN1C-associated BWSp. In total, we evaluated 21 cases of BWSp with CDKN1C variants; 19 were classified as classical BWS according to the BWSp scoring classification by Brioude et al. One of our patients developed a mediastinal ganglioneuroma. Our study adds evidence that tumour development in patients with BWSp and CDKN1C variants is infrequent, but it is extremely relevant to the patient's follow-up and supports the high heterogeneity of BWSp clinical features associated with CDKN1C variants.

Pre-Germination Treatments at Operational Scale for Six Tree Species from the Sclerophyll Forest of Central Chile.

Sclerophyll forest in Mediterranean central Chile has been subjected to severe degradation due to anthropic disturbances and climate change and is in need of restoration. Since direct seeding is usually unsuccessful, we need to research seed propagation to produce plants for restoration. Our objective was to assess pre-germination treatments for six native woody species (Acacia caven, Lithraea caustica, Quillaja Saponaria, Porlieria chilensis, Kageneckia angustifolia, and Ceratonia chilensis) of the sclerophyll forest, considering its operational applicability and consequences for nursery plant production. Treatments were selected according to previous studies, and operational applicability in nurseries. Germination and level of seeds water imbibition were assessed. Results indicate that time for seed water imbibition is critical for germination in A. caven, P. chilensis and K. angustifolia, with an average germination of 90.2 ± 2.0%, 85.0 ± 4.7%, and 47.4 ± 2.3%, respectively. Gibberellin did not improve germination compared to water soaking in Q. Saponaria, K. angustifolia and P. chilensis. In addition, physical scarification is a suitable treatment for L. caustica and C. chilensis, instead of chemical scarification, avoiding handling toxic and corrosive compounds in nurseries. We recommend assessing seed water imbibition rates as a key factor for proper germination processes.

Regioselective Monoborylation of Spirocyclobutenes.

We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycles have been prepared with complete regiocontrol. The boryl moiety provides a synthetic handled for further functionalization, allowing access to a wide array of spirocyclic building blocks from a common intermediate.

Complicated grief, unusual perceptual experiences, and hope in widowhood / Luto complicado, experiências perceptivas incomuns e esperança na viuvez / Duelo complicado, experiencias perceptuales inusuales y esperanza en la viudez

The overall objective of this study is to assess grief in religious widows and hope, and the frequency of unusual perceptual experiences after the death of the spouse. It is hypothesized that (H1) religious widows will experience a less complicated grief, (H2) a greater hope, and (H3) a higher frequency of unusual perceptual experiences than non-religious widows. Three instruments, the Complicated Grief Inventory, the Hope Scale, and the Hallucinations Questionnaire were administered to a sample consisting of religious widows and a control group (non-religious widows). The results showed that religious widows experienced less complicated grief than non-religious widows, and fewer feelings of pessimism about the death of the loved one. Religious widows who showed higher feelings of hope, compared to non-religious ones, tended to have fewer indicators of complicated grief. Furthermore, those religious widows who displayed feelings associated with remembering the deceased tended, for example, to hear voices and smell perfumes. It is possible that these occurrences may even be functional and adaptive in order to cope with the negative feelings of grief and loss, rather than resulting in a resource deficit mechanism for dealing with pain and hopelessness.

O objetivo geral deste estudo é avaliar o luto e a esperança em viúvas religiosas, e a frequência de experiências perceptivas incomuns após a morte do cônjuge. A hipótese é que (H1) viúvas religiosas experimentarão um luto menos complicado, (H2) mais esperança e (H3) maior frequência de experiências perceptivas incomuns do que viúvas não religiosas. Três instrumentos, o Inventário do Luto Complicado, a Escala de Esperança e o Questionário de Alucinações, foram administrados a uma amostra composta por viúvas religiosas e um grupo de controle (viúvas não religiosas). Os resultados mostraram que as viúvas religiosas experimentaram um luto menos complicado do que as viúvas não religiosas e menos sentimentos de pessimismo em relação à morte de um ente querido. As viúvas religiosas que mostraram maior senso de esperança, em comparação com as viúvas não religiosas, tendem a ter menos indicadores de luto complicado. Além disso, aquelas viúvas religiosas que demonstravam sentimentos associados à memória do falecido tendiam, por exemplo, a ouvir vozes e cheirar perfumes. É possível que essas ocorrências possam até ser funcionais e adaptativas para lidar com os sentimentos negativos de luto e perda, em vez de ser um mecanismo de déficit de recursos para lidar com a dor e a desesperança.

El objetivo general de este estudio es evaluar el duelo en viudas religiosas y la esperanza, y la frecuencia de experiencias perceptuales inusuales después de la muerte del cónyuge. Se hipotetiza que (H1) las viudas religiosas experimentarán menor grado de duelo complicado, (H2) mayor esperanza y (H3) mayor frecuencia de experiencias perceptuales inusuales que las viudas no religiosas. Se administraron tres instrumentos, el Inventario de Duelo Complicado, la Escala de Esperanza, y el Cuestionario de Alucinaciones a una muestra integrada por viudas religiosas y un grupo control (viudas no religiosas). Los resultados mostraron que las viudas religiosas experimentaban menos duelo complicado que las viudas no religiosas, y menos sentimientos de pesimismo en torno a la muerte del ser querido. Las viudas religiosas que mostraron mayor sentimiento de esperanza, en comparación con las no religiosas, tendieron a menos indicadores de duelo complicado. Además, aquellas viudas religiosas que mostraban sentimientos asociados al recuerdo del difunto tendían, por ejemplo, a oír voces y oler perfumes. Es posible que estas ocurrencias puedan incluso ser funcionales y adaptativas para afrontar los sentimientos negativos del duelo y la pérdida, en lugar de resultar un mecanismo de déficit de recursos para lidiar contra el dolor y la desesperanza.

Abuso y abandono infantil y estilo parental dominante en relación con las experiencias paranormales en la adultez / Negative childhood experiences, parental styles and resilience among people who report paranormal experiences

Resumen El trauma infantil puede conducir al desarrollo de una personalidad propensa a la fantasía y, luego, desarrollar creencias y experiencias paranormales como estrategia de afrontamiento a la ansiedad durante la vida adulta. Se administró la Encuesta de Experiencias Paranormales, el Cuestionario de Experiencias Negativas en la Niñez, y la Escala de Estilos Parentales a una muestra compuesta por 644 individuos Los resultados indican alta frecuencia de experiencias tales como sensación de presencia (58 %), sueños premonitorios (56 %), telepatía (41 %), experiencias místicas (40 %), apariciones (38 %) y experiencia fuera del cuerpo (25 %). Además, se plantearon dos hipótesis: (H1) en la que se encontraría una relación positiva y significativa entre las experiencias negativas en la niñez (abuso y abandono) y la frecuencia de experiencias paranormales en la vida adulta, lo cual se confirmó (rs = .27, Sig. < .001), con correlaciones fuertes para experiencias tales como sensación de presencia (rs = .23) y apariciones (rs = .19); y (H2) que muestra a individuos que reportan mayor frecuencia de experiencias paranormales y tenderían a mostrar un estilo parental más autoritario en comparación con un estilo parental negligente, sobreprotector, permisivo y autoritativo, lo cual se confirmó para madre: χ2 = 18.24, p < .001, en comparación con un estilo parental negligente, sobreprotector, autoritario y autoritativo. Una posible interpretación es que los eventos traumáticos en la niñez son no solo la fuente para la emergencia de las experiencias paranormales, sino un estilo parental autoritario que contribuye a reforzar el modo en que se procesan cognitiva y emocionalmente tales experiencias negativas.

Abstract Child trauma can lead to the development of a personality fantasy prone and life, to develop paranormal beliefs and experiences as a strategy to cope with anxiety during adulthood. In other words, beliefs and paranormal experiences can be a system of representations that allow us to give sense and meaning to control trauma anxiety, and in general an illusion of control over future disturbing events. There are relatively few studies examining the parental style and paranormal experiences/beliefs, therefore, the aim of this study is to measure the dominant parental style of those who have experienced paranormal events and their correlate with negative events in childhood. The Survey of Paranormal Experiences, the Survey of Negative Experiences in Children, and the Scale of Parental Styles were administered to a sample of 644 individuals of both sexes 28 % males and 72 % females (Mean = 28.13 years) in a simple intentional non-probabilistic sampled technique. The results showed high frequency of experiences such as Sense of presence (58 %), Premonitory dreams (56 %), Telepathy (41 %), Mystical experiences (40 %), Apparitions (38 %), and Out-of-Body experiences (25 %). The results confirmed hypotheses which predict (H1) a positive and significant relationship will be found between negative experiences in childhood and the frequency of paranormal experiences in adult life which was confirmed (rs = .27, p < .001); and (H2) individuals who reported a higher frequency of paranormal experiences showed a more Authoritarian parenting style compared to a Negligent, Overprotective, Permissive and Authoritative parenting style, which was confirmed for Mother χ2 = 18.24, p < .001, but not for Father, who showed a more Permissive style χ2 = 8.11, p < .001 compared to a negligent, overprotective, authoritarian and authoritative parenting style. The results here support, in part, the idea that adult paranormality is an adaptive mechanism that helps individuals cope with an absence of control in childhood. For example, when the parents do not meet the physical, psychological, and/or emotional needs of the child, who ends up being explicitly insulted, ridiculed, shouted at, emotionally manipulated, or unfairly blamed by parents- One possible interpretation is that traumatic events in childhood are not only the source for the emergence of other paranormal experiences but a permissive and negligent parental style helps to reinforce the way in which these negative experiences are processed cognitive and emotionally. The parental bond in childhood and throughout life, can also function as a modulator of the occurrence of the paranormal experience. The parental bond in childhood and throughout life, can also function as a modulator of the occurrence of the paranormal experience. Consequently, the behavior of the parents is an easily available model that children imitate involuntarily. The parental bond in childhood and throughout life can also function as a modulator of the occurrence of paranormal experiences and, to some extent, its cognitive adaptation. In this way, internalization can be a much more active process by which parents strive to inculcate their own beliefs in their children, which may involve an explicit program of instruction and positive encouragement but sometimes a degree of coercion and punishment for their breach as well. Therefore, through the process of internalization, the parents' beliefs can be assimilated into the children's own frame of reference and their anomalous experiences. Parents showed a more permissive parenting style, characterized by greater receptivity than demand, that is, parents are more lenient and tended to give in to the demands of their children and give them support, this parenting style significantly favored such paranormal experiences as sense of presence and "seeing" ghosts.

Stereoselective Diboration of Spirocyclobutenes: A Platform for the Synthesis of Spirocycles with Orthogonal Exit Vectors.

The diastereo- and enantioselective diboration of spirocyclobutenes provides a platform for the rapid preparation of a wide variety of chiral spirocyclic building blocks. The chemoselective functionalization of the carbon-boron bond in the products, including a stereospecific sp3 -sp2 Suzuki-Miyaura cross-coupling reaction, provides a powerful tool to control the directionality and the nature of the exit vectors in the spirocyclic framework.

Epidemiología de la COVID-19 y la embarazada en el mundo y Venezuela

El binomio madre-hijo es una población muy especial y recibe toda la atención social para asegurar su protección y asistencia. La pandemia de la COVID-19 con más de 1 año de duración es un riesgo para muchos grupos vulnerables ya identificados con los estudios epidemiológicos donde resaltan las personas mayores de 65 años, personas con comorbilidades tipo obesidad, hipertensión diabetes, enfermedades cardiovasculares e inmunosupresoras. Se revisan las estadísticas de la COVID-19 en la población general y en las gestantes, con especial revisión de la región de las Américas y Venezuela. Las embarazadas han sido estudiadas durante la pandemia y se concluye que es una población de riesgo más vulnerable a complicaciones durante la gestación, en parto el puerperio y su producto durante la vida neonatal mayor riesgo de enfermar grave y requerir cuidados intensivos. Se insta a los grupos de investigación incorporarse en los protocolos de monitoreo internacionales, y seguir estudiando la COVID-19 en la embarazada y el feto.

The mother-child binomial is a very special population and receives all the social care to ensure its protection and assistance. The COVID-19 pandemic lasting more than 1 year is a risk for many vulnerable groups already identified with epidemiological studies highlighting people over the age of 65, people with obesity-like comorbidities, diabetes hypertension, cardiovascular disease and immunosuppressants. Statistics of the COVID-19 pandemic in the general population and pregnant women are reviewed, with special revision of the Americas and Venezuela region. Pregnant women have been studied during the pandemic and it is concluded that it is a population at risk more vulnerable to complications during pregnancy, childbirth, postpartum and its product during neonatal life increased risk of serious illness and intensive care. Research groups are encouraged to join international monitoring protocols, and further study COVID-19 in pregnant women and fetuses.

Copper, Boron and Vinyl Epoxides: from 1,4-Diols to Cyclopropylboronates.

Herein we describe the reactivity found between vinyl epoxides and catalytically generated copper-boryl complexes. By tuning the substituents of the alkene and/or the reaction conditions, 1,4-diols, allylic alcohols or cyclopropylboronates can be prepared. The stereochemical information of the vinyl epoxide is transferred to the products with high levels of stereocontrol.

Salud pública y pruebas diagnósticas del COVID-19: caso Venezuela / Public health and diagnostics tests for SARS-COVID-2 infection: The venezuela case

La salud pública mundial presenta en la actualidad un reto de grandes dimensiones para realizar las funciones esenciales del Siglo XXI, "el diagnóstico temprano y el tratamiento preventivo de las enfermedades"; por lo tanto la OMS considera que para conocer la magnitud de la epidemia COVID-19 es básico contar con suficientes pruebas diagnósticas en cantidad y calidad. En Venezuela, el Ministerio de la Salud comunica que se han realizado más de 80.484 pruebas por millón de habitantes (marzo-diciembre 2020), las más altas de la región; sin embargo, las pruebas diagnósticas de PCR y Prueba de antígenos, no alcanzan a 1.488,8 (105) y 11,9 (105) respectivamente, muy bajas. Se revisan las pruebas más usadas para detección de genoma, antígenos y serología, mediante pruebas de tiempo y rápidas, ambulatorias o de estricto manejo en laboratorio(AU)

Global public health currently presents a major challenge in performing the essential functions of the 21st century, "early diagnosis and preventive treatment of diseases", so WHO believes that sufficient diagnostic evidence in quantity and quality is essential to understand the scale of the COVID-19 epidemic. In Venezuela, the Ministry of Health reports that more than 80,484 tests per million inhabitants (march-december 2020) have been carried out; however, diagnostic tests of PCR and Antigen Test, do not reach 14,888 (106) and 110 (106) respectively, which is very low compared to neighboring countries. The most commonly used tests for genome, antigen and serology are reviewed(AU)

Nuevo coronavirus (SARS-COV-2): una amenaza global / New Coronavirus (SARS-COV-2): a global threat

El nuevo coronavirus (SARS-CoV-2) identificado en Wuhan, China a principios de enero de 2020, es el agente infeccioso causante de la pandemia COVID -19, la cual ha sido declarada por la Organización Mundial de la Salud (OMS) el 11 de marzo de 2020 y es una amenaza global por el número de casos y muertes así como el importan- te impacto en los sistemas de salud. La enferme- dad se transmite de persona a persona a través de las gotas de saliva al hablar, toser o estornudar o al tocar las mucosas oral, conjuntival y nasal con las manos, después de tocar superficies contami- nadas por el virus. La infección puede ser asinto- mática, la gran mayoría de los pacientes presentan una enfermedad leve o moderada, el 14 % puede presentar neumonía y enfermedad grave, un 5 % o más. El órgano principalmente afectado es el pulmón, sin embargo, es una enfermedad sistémica. La fisiopatología de la enfermedad aún no está bien comprendida, no hay untratamiento específi- co, aunque se están ensayando experimentalmente numerosos fármacos. La vacuna, según los exper- tos, tardará en desarrollarse. Los profesionales sanitarios deben estar familiarizados con los aspectos de la enfermedad, así como con el diagnóstico y las medidas de control, entre otros(AU)

The new coronavirus (SARS-CoV-2) identified in Wuhan, China in early January 2020, is the infectious agent causing the COVID -19 pandemic, declared by the World Health Organization (WHO) on March 11, 2020. It has become a global threat due to the number of cases and deaths and its sig- nificant impact on health systems. The disease is transmitted from person to person by respiratory route through saliva droplets while speaking, coug- hing, or sneezing, or by touching the oral, conjunc- tival, and nasal mucosa with the hands after having touched surfaces contaminated by the virus. The infection may be asymptomatic, the vast majority of patients have mild or moderate disease, 14% may have pneumonia, and 5% or more can suffer severe disease. The main affected organs are the lungs but, it is a systemic disease. The pathophysiology of the disease is still not well understood, there is no specific treatment, although numerous drugs are being experimentally tested and the vaccine, according to experts, could take take some time to be ready. Healthcare profes- sionals should be familiar with all aspects of the disease, as well as diagnosis and control measures(AU)