[Analysis of a clinical ethics committee activities at a general hospital]. / Experiencia del Comité de Ética Asistencial del Hospital Carlos van Buren entre los años 2007-2020.

BACKGROUND: Clinical Ethics Committees are deliberative groups whose main functions are to assess cases with ethical-clinical conflicts, to generate institutional protocols for preventive purposes, and to train health teams. AIM: To analyze the activity of a clinical ethics committee of a general hospital in the period 2007-2020. MATERIAL AND METHODS: A retrospective analysis of all session records, annual reports, case resolution and documents generated by the Clinical Ethics Committee of Carlos van Buren Hospital in Valparaíso, Chile, between 2007 and 2020, was carried out. RESULTS: On average, 12 cases are analyzed per year. Sixty percent correspond to requests from pediatric units and in 78% of these cases there was at least one neurological disease. In 62% of cases, the main ethical dilemma was adequacy of therapeutic effort, followed by dilemmas related to the exercise of autonomy in 18.2%. In education, two courses are identified aimed to doctors, residents, and other members of the health team. Regarding normative functions, several documents were generated at the request of the Hospital management or in different clinical situations. During COVID-19 pandemia, the active role of the committee was linked to the three main functions, namely evaluating cases, participating in morbidity and mortality meetings for preventive purposes, and issuing guidelines and recommendations for action. The active participation of Pediatric Neurology residents in the Committee, for educational and administrative purposes, stands out. CONCLUSIONS: The three main functions described for the ethics committees were exerted by this Committee during the evaluated period. The impact of our recommendations remain to be objectively evaluated.

Experiencia del Comité de Ética Asistencial del Hospital Carlos van Buren entre los años 2007-2020

Background: Clinical Ethics Committees are deliberative groups whose main functions are to assess cases with ethical-clinical conflicts, to generate institutional protocols for preventive purposes, and to train health teams. Aim: To analyze the activity of a clinical ethics committee of a general hospital in the period 2007-2020. Material and Methods: A retrospective analysis of all session records, annual reports, case resolution and documents generated by the Clinical Ethics Committee of Carlos van Buren Hospital in Valparaíso, Chile, between 2007 and 2020, was carried out. Results: On average, 12 cases are analyzed per year. Sixty percent correspond to requests from pediatric units and in 78% of these cases there was at least one neurological disease. In 62% of cases, the main ethical dilemma was adequacy of therapeutic effort, followed by dilemmas related to the exercise of autonomy in 18.2%. In education, two courses are identified aimed to doctors, residents, and other members of the health team. Regarding normative functions, several documents were generated at the request of the Hospital management or in different clinical situations. During COVID-19 pandemia, the active role of the committee was linked to the three main functions, namely evaluating cases, participating in morbidity and mortality meetings for preventive purposes, and issuing guidelines and recommendations for action. The active participation of Pediatric Neurology residents in the Committee, for educational and administrative purposes, stands out. Conclusions: The three main functions described for the ethics committees were exerted by this Committee during the evaluated period. The impact of our recommendations remain to be objectively evaluated.

Radical vaginal trachelectomy and laparoscopic pelvic lymphadenectomy in IB1 cervical cancer during pregnancy.

► We expose an novel surgical technique in pregnant women with cervical cancer. ► We preserve the pregnancy in this case. ► After 40 months of monitoring both patient and her child are healthy.

Destrucción de la capa de ozono y sus implicancias / Destruction of the ozone layer and its implications

El ozono (O3) se encuentra en la estratósfera en una concentración variable que oscila alrededor de 1/1.000.000. Su propiedad más importante es la de absorver los fotones de las radiaciones ultravioletas menores de 315 nm. (UVC y parte de UVB). En la última década, productos químicos tales como los clorofluorocarburos y los bromuros han dañado la capa de ozono, creando en ella un agujero ubicado sobre el Continente Antártico, lo que tiene especial trascendencia para Chile. La disminución de la capa protectora de ozono implica un mayor riesgo de exposición a radiaciones ultravioletas y, por ende, de envejecimiento cutáneo y de cánceres de piel. Ello acentúa la importancia de todas las medidas de fotoprotección

Mayores niveles séricos de IgM en mujeres en relación a hombres usando un modelo de heteroaglutinina humana anti raton / Higher women IgM levels compared with men in a model of human anti mouse heteroagglutinins

Se probaron 68 muestras de hombres y 67 mujeres de sueros anti ABO con glóbulos rojos de ratones silvestres. Sesenta y cinco muestras en ambos casos aglutinaron los glóbulos rojos de ratón. Considerando o no el grupo sanguíneo ABO de los donantes, en los dos casos se obtuvo un promedio de título de esta heteroaglutinina mucho mayor en mujeres que en hombres. Las diferencias fueron estadísticamente significativas (p < 0,001). Los eritrocitos de ratón fueron aglutinados por la fracción IgM del suero y no por la fracción IgG. Nuestros resultados están de acuerdo con la hipótesis que relaciona la concentración sérica de IgM y el número de cromosomas X que posea un individuo, postulándose una mayor concentración, en mamíferos, de IgM en hembras en relación a los machos