[The role of NADPH-oxidase in paracrine and autocrine regulation of platelet functional activity].

NADPH-oxidase (NOX) is a novel transmembrane enzyme that appears to have pivotal role in the control of platelet signal pathways. The NOX activity in platelets is controlled by agonist receptors activation, which, in turn are modulated by NOX. This review focuses on participation of NOX in autocrine and paracrine regulation of platelet activation, aggregation secretion, protein synthesis and cell recruitment processes during thrombus formation. Possible involving of NOX in the cell-to-cell communication and coordination in response to trombogenic stimulus is discussed.

[Hemostasis system and inflammation acute-phase proteins in thrombogenic pathologies].

New knowledge concerning the role of inflammation in activation of fibrinolysis and in discoordination of its components interaction has been presented in the review. Considerable attention was given to molecular mechanisms of the haemostatic protein involvement in the acute phase of inflammation. An analysis of their level changes according to inflammation state has been proposed for thrombogenic risk assessment. Abundant consumption of plasminogen in situ as a result of coagulation induced by moderate level of inflammation is the first critical point in thrombus formation. Activated protein C leakage during severe inflammation is another trigger of thrombogenesis leading to possible death.

[Investigation of oxosubstances in plant leaf lipids]. / Doslidzhennia oksospoluk poverkhnevykh lipidiv lystkiv roslyn.

Surface lipids of plant leaves of different groups were investigated by spectral, chromatographic and functional analysis methods. Absence of oxosubstances in surface lipids of coniferous and their characteristics in tropical species were shown. Functions of oxosubstances are discussed.