RESUMO
Schnitzler's syndrome has been described in 1972. It associates a chronic urticaria with leukocytoclastic vasculitis, a macroglobulinemia, bone pains, hyperostosis. In the twenty three cases reported, the evolution is benign but three patients including the princeps case developed a Waldenström's disease or a lymphoplasmocytic lymphoma. We present the case of one patient, aged 65, with Schnitzler's syndrome, who, after 6 years evolution, presents a IgM myeloma. Schnitzler's syndrome appeared as a pre-hemopathic state which has to be taken care of regularly and for a long time.
Assuntos
Imunoglobulina M , Mieloma Múltiplo/etiologia , Urticária/complicações , Macroglobulinemia de Waldenstrom/complicações , Corticosteroides/uso terapêutico , Idoso , Clorambucila/uso terapêutico , Doença Crônica , Humanos , Masculino , Mieloma Múltiplo/tratamento farmacológico , Síndrome , Fatores de Tempo , Urticária/tratamento farmacológico , Urticária/fisiopatologia , Macroglobulinemia de Waldenstrom/tratamento farmacológico , Macroglobulinemia de Waldenstrom/fisiopatologiaRESUMO
The authors report three cases of osteoporotic vertebral fractures in the Cushing Syndrome. This osteoporosis is partially reversible after treatment of the cause. Laboratory findings must comport a cortisonuric and a 17 hydroxycorticosterone cycle.