Future Climate Effects on Yield and Mortality of Conventional versus Modified Oil Palm in SE Asia.

Palm oil is a very important commodity which will be required well into the future. However, the consequences of growing oil palm (OP) are often detrimental to the environment and contribute to climate change. On the other hand, climate change stress will decrease the production of palm oil by causing mortality and ill health of OP, as well as reducing yields. Genetically modified OP (mOP) may be produced in the future to resist climate change stress, although it will take a long time to develop and introduce, if they are successfully produced at all. It is crucial to understand the benefits mOP may bring for resisting climate change and increasing the sustainability of the palm oil industry. This paper employs modeling of suitable climate for OP using the CLIMEX program in (a) Indonesia and Malaysia, which are the first and second largest growers of OP respectively, and (b) Thailand and Papua New Guinea, which are much smaller growers. It is useful to compare these countries in terms of future palm oil production and what benefits planting mOP may bring. Uniquely, narrative models are used in the current paper to determine how climate change will affect yields of conventional OP and mOP. The effect of climate change on the mortality of mOP is also determined for the first time. The gains from using mOP were moderate, but substantial, if compared to the current production of other continents or countries. This was especially the case for Indonesia and Malaysia. The development of mOP requires a realistic appreciation of what benefits may accrue.

Special Issue: Coffee, Fungi, Mycotoxins, and Climate Change.

Coffee is very lucrative and enjoyed by many [...].

Climate Refuges in Nigeria for Oil Palm in Response to Future Climate and Fusarium Wilt Stresses.

The detrimental stresses of future climate change are well known and decisions are required to reduce their effects. Climate and disease stresses cause severe damage to plants and it is essential to understand how they will respond. Oil palm (OP) is an Fusarium important crop for many countries. The palm originated in Africa, where palm oil is produced in the largest amount within the continent by Nigeria. OP becomes stressed by climate change and wilt, a devastating disease of OP in Africa. Previous methods to determine the suitability of future climate on OP in continents and whole countries were applied to Nigeria, which is the first time an individual country has been assessed in this manner. Climate maps of Nigeria were divided equally into 16 regions from north to south and east to west to determine the future suitable climate for growing OP. CLIMEX and narrative modelling were used to determine suitability for growing OP and Fusarium wilt incidence for current time and 2050. Maps from published papers were employed directly thereby facilitating the procedure. A distinct latitudinal increasing trend from north to south in suitable climate was observed, which was unexpected. A decreasing longitudinal trend from west to east was also observed. These differences in suitable climates may allow refuges for OP in the future. The growth of OP in the south of Nigeria may be largely unaffected by climate change by 2050, unlike the north. The procedures allow policy decisions at state and national levels to be made from empirical data, which do not otherwise exist. States with low amounts of OP and where the climate deteriorates greatly, could usefully be abandoned. Other low palm oil producers, where the climate does not deteriorate greatly, could be encouraged to develop OP. Little requires to be done in the high producing states where the climate does not deteriorate. In all cases, the environmental impacts require thorough assessment. Climate change requires reduction as indicated in recent Conference of the Parties meetings.

Medical Comorbidities and Medication Use Among Homeless Adults Seeking Mental Health Treatment.

Little is known about the medical conditions and medication use of individuals who are homeless and have mental health problems. This study used secondary data (N = 933) from a mental health clinic serving homeless adults. Primary outcomes were the number and types of self-reported medical conditions and medications. About half (52.60%) of participants were taking one or more medications (mean = 1.67; SD = 2.30), most commonly antidepressants, antipsychotics, and anticonvulsants. Most frequently reported medical conditions were headaches/migraines, hypertension, and arthritis with a mean of 3.09 (SD = 2.74) conditions. Age and sex were significant predictors of the number of medical conditions. Age and the length of time homeless were significant predictors of the number of medications taken. Results suggest that those who are older and have been homeless longer appear to be increased risk for health problems and may need more medications to manage these conditions.

Cardiac sarcoidosis in monozygotic twins: An opportunity for early surveillance and treatment.

Genetic factors play an important role in the development of cardiac sarcoidosis and may determine disease pattern, severity, and prognosis. A 55-year-old African American male presented with new onset of congestive heart failure. This patient was diagnosed with pulmonary sarcoidosis eleven years prior and initially treated with prednisone. He was lost to follow-up until this index admission. He had a monozygotic twin brother who was diagnosed with pulmonary and cardiac sarcoidosis, and passed away from severe biventricular dysfunction. Surveillance, with echocardiography or cardiac MRI, in siblings at high risk of sarcoidosis may allow for early detection and treatment.

Thermophilic Fungi to Dominate Aflatoxigenic/Mycotoxigenic Fungi on Food under Global Warming.

Certain filamentous fungi produce mycotoxins that contaminate food. Mycotoxin contamination of crops is highly influenced by environmental conditions and is already affected by global warming, where there is a succession of mycotoxigenic fungi towards those that have higher optimal growth temperatures. Aflatoxigenic fungi are at the highest limit of temperature although predicted increases in temperature are beyond that constraint. The present paper discusses what will succeed these fungi and represents the first such consideration. Aflatoxins are the most important mycotoxins and are common in tropical produce, much of which is exported to temperate regions. Hot countries may produce safer food under climate change because aflatoxigenic fungi will be inhibited. The same situation will occur in previously temperate regions where these fungi have recently appeared, although decades later. Existing thermotolerant and thermophilic fungi (TTF) will dominate, in contrast to the conventional mycotoxigenic fungi adapting or mutating, as it will be quicker. TTF produce a range of secondary metabolites, or potential mycotoxins and patulin which may become a new threat. In addition, Aspergillus fumigatus will appear more frequently, a serious human pathogen, because it is (a) thermotolerant and (b) present on crops: hence this is an even greater problem. An incubation temperature of 41 °C needs employing forthwith to detect TTF. Finally, TTF in crops requires study because of the potential for diseases in humans and animals under climate change.

Valuing shifts in the distribution of visibility in national parks and wilderness areas in the United States.

Environmental regulations often have the objective of eliminating the lower tail of an index of environmental quality. That part of the distribution of environmental quality moves somewhere above a threshold and where in the original distribution it moves is a function of the control strategy chosen. This paper provides an approach for estimating the economic benefits of different distributional changes as the worst environmental conditions are removed. The proposed approach is illustrated by examining shifts in visibility at Class I visibility areas (National Parks and wilderness areas) that would occur with implementation of the U.S. Environmental Protection Agency's Regional Haze Program. In this application we show that people value shifts in the distribution of visibility and place a higher value on the removal of a low visibility day than on the addition of a high visibility day. We found that respondents would pay about $120 per year in the Southeast U.S. and about $80 per year in the Southwest U.S. for improvement programs that remove the 20% worst visibility days.

Integrating ecosystem services analysis into scenario planning practice: accounting for street tree benefits with i-Tree valuation in Central Texas.

Scenario planning continues to gain momentum in the United States as an effective process for building consensus on long-range community plans and creating regional visions for the future. However, efforts to integrate more sophisticated information into the analytical framework to help identify important ecosystem services have lagged in practice. This is problematic because understanding the tradeoffs of land consumption patterns on ecological integrity is central to mitigating the environmental degradation caused by land use change and new development. In this paper we describe how an ecosystem services valuation model, i-Tree, was integrated into a mainstream scenario planning software tool, Envision Tomorrow, to assess the benefits of public street trees for alternative future development scenarios. The tool is then applied to development scenarios from the City of Hutto, TX, a Central Texas Sustainable Places Project demonstration community. The integrated tool represents a methodological improvement for scenario planning practice, offers a way to incorporate ecosystem services analysis into mainstream planning processes, and serves as an example of how open source software tools can expand the range of issues available for community and regional planning consideration, even in cases where community resources are limited. The tool also offers room for future improvements; feasible options include canopy analysis of various future land use typologies, as well as a generalized street tree model for broader U.S. application.

Toxicology of mycotoxins.

Humans are exposed to mycotoxins via ingestion, contact and inhalation. This must have occurred throughout human history and led to severe outbreaks. Potential diseases range from akakabio-byo to stachybotryotoxicosis and cancer. The known molecular bases of toxicology run the gamut of 23 compounds, from aflatoxins (AFs) to zearalenone, ochratoxin A and deoxynivalenol. Ergotism is one of the oldest recognized mycotoxicosis, although mycotoxin science only commenced in the 1960s with the discovery of AFs in turkey feed. AFs are carcinogenic. Some others are suspected carcinogens. The effects of mycotoxins are acute or chronic in nature. Mycotoxins are well known in the scientific community, although they have a low profile in the general population. An incongruous situation occurs in United States where mycotoxins from "moldy homes" are considered to be a significant problem, although there is a general debate about seriousness. This contrasts with the thousands of deaths from mycotoxins that occur, even now, in the technologically less developed countries (e.g., Indonesia, China, and Africa). Mycotoxins are more toxic than pesticides. Studies are moving from whole animal work to investigating the biochemical mechanisms in isolated cells, and the mechanisms of toxicity at the molecular level are being elucidated. The stereochemical nature of AFs has been shown to be important. In addition, the effect of multiple mycotoxins is being increasingly investigated, which will more accurately represent the situation in nature. It is anticipated that more fungal metabolites will be recognized as dangerous toxins and permitted statutory levels will decrease in the future.

Biodegradation of ochratoxin a for food and feed decontamination.

Ochratoxin A (OTA) is one of the most important mycotoxins that is found in food and feed products. It has proven toxic properties, being primarily known for its nephrotoxicity and carcinogenicity to certain animal species. OTA is produced by several species of Aspergillus and Penicillium that can be found in a wide variety of agricultural products, which makes the presence of OTA in these products common. Many countries have statutory limits for OTA, and concentrations need to be reduced to as low as technologically possible in food and feed. The most important measures to be taken to control OTA are preventive in order to avoid fungal growth and OTA production. However, these measures are difficult to implement in all cases with the consequence of OTA remaining in agricultural commodities. Remediation processes are often used to eliminate, reduce or avoid the toxic effects of OTA. Biological methods have been considered increasingly as an alternative to physical and chemical treatments. However, examples of practical applications are infrequent. This review will focus on the (i) known microorganisms and enzymes that are able to biodegrade OTA; (ii) mode of action of biodegradation and (iii) current applications. A critical discussion about the technical applicability of these strategies is presented.

Heterogeneity in preferences for smoking cessation.

Promoting cessation is a cornerstone of tobacco control efforts by public-health agencies. Economic information to support cessation programs has generally emphasized cost-effectiveness or the impact of cigarette pricing and smoking restrictions on quit rates. In contrast, this study provides empirical estimates of smoker preferences for increased efficacy and other attributes of smoking cessation therapies (SCTs). Choice data were collected through a national survey of Canadian smokers. We find systematic preference heterogeneity for therapy types and SCT attributes between light and heavy smokers, as well as random heterogeneity using random parameters logit models. Preference heterogeneity is greatest between length of use and types of SCTs. We estimate that light smokers would be willing to pay nearly $500 ($CAN) to increase success rates to 40% with the comparable figure for heavy smokers being near $300 ($CAN). Results from this study can be used to inform research and development for smoking cessation products and programs and suggest important areas of future inquiry regarding heterogeneity of smoker preferences and preferences for other health programs.

Long-wave cycles in the position of erupting human premolars.

OBJECTIVE: Unusual long-wave cycles in the position of an erupting human premolar were first noted by Trentini et al. [Trentini CJ, Brown WH, Paterson RL, Proffit WR. The application of Moire magnification to high precision studies of human premolar eruption. Arch Oral Biol 1995;40:623-9]. This report characterises them in detail and evaluates their significance relative to human tooth eruption. DESIGN: The magnitude and frequency of Trentini cycles were examined in high-resolution recordings of premolar eruption in patients without and with periapical infiltration of a vasoconstrictor or vasodilator, and the possibility of artifact due to the natural frequency of vibration of a tooth-PDL system or to building vibration was evaluated. RESULTS: The cycles are characterised by a magnitude of 1.3 +/- 0.5 microm and a frequency of 1.8 +/- 0.5 cycles per minute, with greater variation between than among subjects. They cannot be explained as a natural frequency phenomenon, and vibration from microseism is highly unlikely. The cycles disappear when blood flow to the periapical area of the tooth is interrupted and reappear when blood flow resumes. CONCLUSIONS: The cycles appear to reflect a physiologic rhythm, probably related to blood flow in the periodontal ligament. Because they are similar whether or not a tooth is erupting at a particular time, however, it appears that they are not a direct reflection of a blood flow-related eruption mechanism.

Response of erupting human second premolars to blood flow changes.

The effect of infiltration of a vasodilator and a vasoconstrictor [2% lidocaine (lignocaine) without or with 1:100,000 adrenaline (epinephrine)] above the root apex of human second premolars in the prefunctional stage of post-emergent eruption was evaluated for 11 teeth in eight children. On two consecutive days, 30 min of high-resolution data on changes in tooth position were collected for each participant during each of four sessions, two in the afternoon and two in the evening, using an optical instrument based on Moiré magnification with 0.05 microm resolution. The immediate reaction to the 1.8 ml injection was extrusion of the tooth, which lasted 2-4 min. After that, in the majority of teeth receiving a vasodilator, the reaction was an increased rate of eruption. In teeth receiving a vasoconstrictor, a decrease in eruption or intrusion was noted after the initial extrusion. The low-frequency Trentini cycles characteristic of erupting teeth were immediately obliterated in all teeth receiving injections. In the next few minutes, the cycles reappeared in teeth receiving the vasodilator, but did not reappear or reappeared only partially in teeth receiving the vasoconstrictor. It appears that vascular changes can influence the rate of prefunctional post-emergent eruption.

Drug-induced meningitis.

Preview Drug-induced aseptic meningitis is an unusual adverse reaction associated with a number of medications. In this report, the authors present a case related to use of trimethoprim- sulfamethoxazole and summarize the available data regarding various proposed mechanisms of drug-induced meningitis. The usual clinical presentation and course of the disorder are discussed.