Maternal periodontal status, oral inflammatory load, and systemic inflammation are associated with low infant birth weight.

BACKGROUND: Periodontal disease and pregnancy outcomes have been claimed to be associated with conflicting reports. The purpose of this study was to prospectively examine the association between maternal periodontal status, oral inflammatory load and serum C- reactive protein (CRP) level, and infant birth weight. METHODS: A total of 156 pregnant women (age 26.62 ± 3.93 years) within the gestational age group of 13 to 32 weeks participated in this cross-sectional study. Oral inflammatory load (OIL) was assessed in a salivary rinse sample using fluorescence microscopy. Clinical periodontal parameters were recorded and serum C-reactive protein level (CRP) was assessed. Participants were followed till delivery, details of parturition and infant birth weight (IBW) was recorded. RESULTS: OIL was significantly more in participants with mild and moderate periodontitis as compared to those with gingivitis in mid and late stages of pregnancy. Periodontal and systemic inflammatory parameters were positively correlated. A significant negative correlation was found between IBW and OIL (P = 0.006) and serum CRP (P < 0.001). The GI score (P = 0.039), BOP% (P = 0.023), serum CRP level (P < 0.001) and oral polymorphonuclear neutrophil (oPMN) count (P < 0.001) was significantly more in mothers delivering babies with low IBW. A multiple linear regression analysis showed that only oPMN (ß = - 0.244, P = 0.021) and serum CRP (ß = - 0.226, P = 0.019) were included in the best model (R2  = 0.12, F(3,152) = 7.15, P < 0.001) for significantly predicting the infant birth weight. CONCLUSIONS: Poor maternal periodontal status, increased oral inflammatory load and increased systemic inflammation have an adverse effect on infant birth weight.

Otological manifestations in pregnant women - A study at a tertiary care hospital of eastern India.

BACKGROUND: There are several physiological changes found in pregnant women and amongst them, otological changes are quite important. The otological manifestations in pregnant women are mainly due to changes of sex hormones levels, which return to normal in the postpartum period. OBJECTIVE: To report otological manifestations among pregnant women. MATERIALS AND METHODS: Eighty-four pregnant women participated in this prospective study. A questionnaire was administered in all participants for assessing otological manifestations. The pregnant women were in the age range of 22-35 years. They underwent thorough otological and obstetric examinations. Pure tone audiometry (PTA) was done for assessment of hearing loss. RESULTS: The mean age of the pregnant women in this study was 26.23 years. The most common otological manifestation was sensation of ear blockage. Eustachian tube dysfunction was common in the last trimester of pregnancy. Other manifestations included vertigo and tinnitus. CONCLUSION: The alteration of hormonal milieu in pregnant women can lead to several otological manifestations, including eustachian tube dysfunction, hearing impairment, otitis externa, Bell's palsy, vertigo and tinnitus. Despite these otological manifestations found in pregnant women, yet they are often neglected in clinical practice.