Co-existence of diabetes and TB among adults in India: a study based on National Family Health Survey data.

Multiple studies suggest that diabetes mellitus (DM) is a potential risk factor for tuberculosis (TB) development and treatment, especially in low- and middle-income countries. The study aimed to test concomitancy between DM and TB among adults in India. Data were from the 2015-16 National Family Health Survey (NFHS-4). The study sample comprised 107,575 men aged 15-54 and 677,292 women aged 15-49 for which data on DM status were available in the survey. The association between state-level prevalence of TB and DM was examined and robust Poisson regression analysis applied to examine the effect of DM on TB. A high prevalence of TB was observed among individuals with diabetes in India in 2015-16. A total of 866 per 100,000 men and 405 per 100,000 women who self-reported having diabetes also had TB; among those who self-reported not having diabetes the ratios were 407 per 100,000 men and 241 per 100,000 women. The risk of having TB among those who self-reported having DM was higher for both men (2.03, 95% CI: 1.26, 3.28) and women (1.79, 95% CI: 1.48, 2.49) than for those who did not self-report having DM. Adults who were diagnosed with diabetes (including pre-diabetes) also had a higher rate of TB (477 per 100,000 men and 331 per 100,000 women) than those who were not diagnosed (410 per 100,000 men and 239 per 100,000 women). Adults from poor families, with lower BMIs, lower levels of literacy and who were not working had a higher risk of TB-DM co-morbidity. The state-level pattern of co-morbidity, the under-reporting of DM (undiagnosed) and TB stigmatization are discussed. The study confirms that diabetes is an important co-morbid feature with TB in India, and reinforces the need to raise awareness on screening for the co-existence of DM and TB with integrated health programmes for the two conditions.

Metal citrate nanoparticles: a robust water-soluble plant micronutrient source.

A series of iron (Fe) and zinc (Zn) plant nanonutrients in citrate form were prepared by an eco-friendly solid-state grinding of the respective nitrates and citric acid. Ball-milling of the as-prepared Fe and Zn citrates resulted in nanosize particles. The as-prepared and ball-milled Fe and Zn citrates were characterized using Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis and differential thermal analysis (TGA/DTA), and powder X-ray diffraction (XRD). The particle size and morphology of the obtained samples were studied using a scanning electron microscope (SEM) and transmission electron microscope (TEM). The obtained nanosized Fe and Zn citrates were analyzed for their plant uptake in the test crop soybean (var. JS-335) using the white-sand technique. The concentration of nutrients was estimated by atomic absorption spectrometry (AAS). A significant increase in nutrient absorption was observed in 6 h ball-milled samples of both Fe (789.8 µg per g of dry weight) and Zn (443.8 µg per g of dry weight) citrates. Such an increased nutrient absorption is due to the high mobility of nanocitrates. Therefore, nanocitrates can serve as an excellent source of plant nutrients in agriculture.

New gold standard: weakly capped infant Au nanoclusters with record high catalytic activity for 4-nitrophenol reduction and hydrogen generation from an ammonia borane-sodium borohydride mixture.

Increasing the surface area-to-volume ratio of materials through size reduction is a desired approach to access maximum possible surface sites in applications such as catalysis. However, increase in the surface energy with the decrease in dimension warrants strong ligands to stabilize nanosystems, which mask the accessibility of the active surface sites. Owing to this, the realization of the true potential of a catalyst's surface remains challenging. Here, we employed a rationally designed strategy to synthesize infant Au nanoclusters-that alleviates the requirement of any separate ligand removal step-to unleash their actual potential to register a record high maximum turn-over frequency (TOFmax) of 72 900 h-1 and 65 500 h-1 in the benchmark catalytic reduction of 4-nitrophenol and catalytic H2 generation from an ammonia borane-sodium borohydride mixture, respectively. Such a phenomenal catalytic activity has been realized via the synthesis and stabilization of Au nanoclusters using solid citric acid and a super-concentrated aqueous AuCl3 solution, a pathway entirely different from the conventional modifications of the Turkevich and Brust methods. The crux of the synthetic strategy lies in precise control of the water content and thereby ensuring that the final Au nanoclusters remain in the solid state. During the synthesis, citric acid not only acts as a reducing agent to yield 'infant' Au nanoclusters but also provides a barrier matrix to arrest their growth. In solution, its weak capping ability and rapid dissolution allows the reactants to easily access the active sites of Au nanoclusters, thus leading to faster catalysis. Our study reveals that the true potential of metal nanoclusters as catalysts is actually far higher than what has been reported in the literature.

Large Scale Solid-state Synthesis of Catalytically Active Fe3O4@M (M = Au, Ag and Au-Ag alloy) Core-shell Nanostructures.

Solvent-less synthesis of nanostructures is highly significant due to its economical, eco-friendly and industrially viable nature. Here we report a solid state synthetic approach for the fabrication of Fe3O4@M (where M = Au, Ag and Au-Ag alloy) core-shell nanostructures in nearly quantitative yields that involves a simple physical grinding of a metal precursor over Fe3O4 core, followed by calcination. The process involves smooth coating of low melting hybrid organic-inorganic precursor over the Fe3O4 core, which in turn facilitates a continuous shell layer post thermolysis. The obtained core-shell nanostructures are characterized using, XRD, XPS, ED-XRF, FE-SEM and HR-TEM for their phase, chemical state, elemental composition, surface morphology, and shell thickness, respectively. Homogeneous and continuous coating of the metal shell layer over a large area of the sample is ascertained by SAXS and STEM analyses. The synthesized catalysts have been studied for their applicability towards a model catalytic hydrogen generation from NH3BH3 and NaBH4 as hydrogen sources. The catalytic efficacy of the Fe3O4@Ag and Ag rich alloy shell materials are found to be superior to the corresponding Au counterparts. The saturation magnetization studies reveal the potential of the core-shell nanostructured catalysts to be magnetically recoverable and recyclable.