Prevalencia de lesiones de bajo y alto grado de cuello uterino en una ciudad colombiana / Prevalence of lesions of low and high grade cervical in a Colombian city

Objetivo: Determinar la prevalencia de las lesiones de bajo y alto grado de cuello uterino en una Institución Prestadora de Servicios de Salud de Tuluá, Colombia, entre los años 2008-2010. Métodos: Se realizó un estudio descriptivo retrospectivo en el que se incluyeron mujeres entre los 15 y 75 años, residentes en el Municipio de Tuluá. Se evaluó la normalidad de las variables cuantitativas, empleándose la mediana o el promedio con sus varianzas según su distribución, y frecuencias y proporciones para las variables categóricas. Resultados: Se incluyeron 3.539 mujeres. La mediana de la edad fue 38 años con rango intercuartil (RI: 29-46 años), la mediana del número de partos 1 (RI: 0-3). En relación a la seguridad social y uso de métodos anticonceptivos, la mayoría eran particulares y no utilizaban ningún método. El 87,5 por ciento de las citologías se reportaron como negativas, 8,2 por ciento lesión de bajo grado (LSIL), 2,6 por ciento células escamosas atípicas de significado indeterminado (ASC-US), 0,9 por ciento lesiones de alto grado (HSIL), 0,4 por ciento células escamosas atípicas de significado indeterminado de alto grado ASC-H, 0,4 por ciento células glandulares atípicas de significado incierto (ASGUS) y 0,2 por ciento carcinoma invasor. Conclusión: La prevalencia de las anormalidades citológicas fue baja en todos los grupos analizados, sin embargo, existe un mayor número de LSIL hacia la cuarta década de la vida y en aquellas que iniciaron su vida sexual después de los 40 años. De igual manera se encontró una relación inversa entre el número de partos, planificación familiar hormonal y aparición de lesiones pre neoplásicas.

Objective: To determine the prevalence of lesions of low and high grade cervical in a Lender Institution Health Services, Tuluá, Colombia, 2008-2010. Methods: We performed a retrospective study which included women between 15 and 75 years living in Tuluá. We evaluated the normality of quantitative variables, using the median or average with their variances for quantitative variables according to their distribution and frequencies and proportions for categorical variables. Results: 3539 women were included. The median age was 38 years with interquartile range (IR: 29-46 years) and the median parity was 1 (IR: 0-3). In relation to social security and family planning birth control, most were private and did not use any method. The 87.5 percent of smears was reported as negative, low-grade squamous intraepitelial lesions (LSIL) 8.2 percent atypical squamous cells of undetermined significance (ASC-US) 2.6 percent, high-grade squamous intraepitelial lesions (HSIL) 0.9 percent, atypical squamous cells cannot rule out a high grade lesion (ASC-H) 0.0 percent, atypical squamous glandular cells of undetermined significance (ASGUS) 0.4 percent and invasive carcinoma 0.2 percent. Conclusion: The prevalence of cytological abnormalities was low in all groups studied, however, a greater number of LSIL to the fourth decades of life and those who began their sexual life after 40 years. Similarly, an inverse relationship was found between parity, hormonal family planning and pre-neoplastic lesions.

Effect of knee osteoarthritis on the perception of quality of life in Venezuelan patients.

OBJECTIVE: To measure the perception of quality of life in Venezuelan patients with knee osteoarthritis and to identify those variables that may influence it. METHODS: A multicenter, cross-sectional study of 126 mestizo patients with knee osteoarthritis recruited from 8 rheumatology centers in Venezuela. We used a Spanish-translated version of the Arthritis Impact Measurement Scales (AIMS), as adapted in Venezuela. One-way analysis of variance was used to compare the AIMS mean total score among subgroups of knee pain, anatomic stage, and socioeconomic status (SES); a post-hoc test was performed to identify significant intragroup differences. Pearson's correlation coefficient was used to examine correlations between age, body mass index (BMI), disease duration, knee pain, and AIMS score. Associations between radiologic stage, SES, and AIMS scores were examined using Spearman's rank correlation. Multiple regression analysis was used to estimate predictor factors of AIMS scores. RESULTS: A significant correlation was found between total AIMS scores and knee pain, age, and socioeconomic status, but not with BMI, disease duration, or anatomic stage. Patients with severe knee pain differed from those with mild and moderate pain, and the highest AIMS mean total score was seen in patients within the severe knee pain subset. Patients in the highest socioeconomic levels differed from those within lowest categories. Patients classified as being at the levels of relative and critical poverty showed the highest AIMS scores. Multiple regression analysis showed that knee pain was the only variable that exerted an independent effect on the quality of life in our patients. CONCLUSION: The perception of quality of life is negatively affected by increasing levels of joint pain, old age, and low socioeconomic status in Venezuelan patients with knee osteoarthritis. Our study supports the need for an early and vigorous approach to treat pain in this group of patients.

Hepatitis por Citomegalovirus. A propósito de una paciente con artritis reumatoidea juvenil complicada / Hepatitis by cytomegalovirus. A propos of the patient with juvenile rheumatoid arthritis complicate

Se presentan los hallazgos clínicos y de laboratorio en una joven con artritis reumatoide juvenil tratada con esteroides, la cual presentó un cuadro infeccioso terminal caracterizado por fiebre, insuficiencia respiratoria, ictericia y arritmia ventricular. La "biopsia hepática postmortem" permitió comprobar una hepatitis aguda por citomegalovirus. Se comentan aspectos diversos de esta modalidad de hepatitis viral descrita por primera vez en Venezuela