[Receptor characteristics of the duodenal mucosa in peptic ulcer: a new approach to the individual selection of the therapy]. / Retseptornaia kharakteristika duodenal'noi slizistoi pri iazvennoi bolezni: novyi podkhod k individualizirovannomu vyboru terapii.

The radioligand-receptor method was used to assay the M-cholinereceptors and opioid binding centers in biopsy specimens of the duodenal mucosa from 40 patients with duodenal ulcer as compared with the results of subsequent therapy by means of gastrocepin (20 patients) and dalargin (20 patients). Analysis of the isothermal curve of 3H-QNB-binding with duodenal mucosa membranes within Skatchard's coordinates showed the presence of 2 subtypes of muscarinic receptors blocked (M1) and not blocked (M2) by gastrocepin. The majority of the patients in both groups demonstrated a significant decrease of the dissociation constant as compared to the control (20 patients). In patients with high receptor sensitivity to gastrocepin and dalargin, ulcer cicatrization was noted during the treatment in all the cases. Meanwhile the treatment proved little effective in patients with appreciably decreased receptor sensitivity to the drugs under consideration. The data obtained indicate the possibility of predicting the results of duodenal ulcer treatment by means of the radioreceptor analysis, providing the basis for the individualized treatment choice.

[Arteriovenous fistulas for extrarenal purification of blood using the brachial artery]. / Arteriovenoznye fistuly dlia vnepochechnogo ochishcheniia krovi s ispol'zovaniem plechevoi arterii.

The article analyzes an experience with creation of different variants of arteriovenous fistulas (AVF) for the extrahepatic purification of blood by using the humeral artery. The above mentioned AVFs were shown to be expedient in patients with small diameters of the forearm vessels or in cases with no possibility to make AVF in the forearm. It is better to make AVF with the antegrade blood flow in the veins. The use of vascular transplants is indicated when there are no veins in the upper extremity suitable for AVF.