Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial.

BACKGROUND: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods. Thus, the need to investigate new methods is essential. This study aims to investigate ovulation induction outcomes in patients with decreased ovarian reserve (DOR) in two groups treated with double stimulation (DuoStim) during the follicular and luteal phases in comparison with the antagonist cycle. MATERIALS AND METHODS: This was a randomised clinical trial that enrolled the patients with reduced ovarian reserve. The patients referred for in vitro fertilization (IVF) at Molud Infertility Clinic, Ali Ebn Abitalib (AS) Hospital, Zahedan, Iran from 2020 to 2021. Participants were randomly divided into two groups, those who underwent treatment with DuoStim during the follicular and luteal phase (case group) and those who received the conventional antagonist cycle (control group). RESULTS: The mean number of metaphase II (MII) eggs was 7.7 ± 3.1 in the case group and 6.1 ± 3.9 in the control group (P=0.063). The mean total number of retrieved eggs in the case group was 9.2 ± 3.7 and in the control group, it was 6.9 ± 4.4 (P=0.023). The mean number of embryos obtained in the case group was 6.5 ± 3.9; in the control group, it was 4.7 ± 2.8 (P=0.016). CONCLUSION: The DuoStim method can effectively play a role in increasing the total number of retrieved eggs and embryos (registration number: IRCT20120817010617N8).

Prevalence of maternal mortality causes based on ICD-MM: a systematic review and meta-analysis.

BACKGROUND: Maternal mortality is a universal public health challenge. ICD-Maternal Mortality (ICD-MM) was introduced in 2012 to facilitate the gathering, analysis, and interpretation of data on maternal deaths worldwide. The present study aimed to estimate the global prevalence of maternal death causes through a systematic review and meta-analysis. METHODS: A systematic literature search was conducted using various databases, including Web of Science, PubMed, Scopus, ScienceDirect, Cochrane Library, as well as Persian databases such as MagIran and Scientific Information Database (SID). The search encompassed articles published until August 21, 2022. Thirty-four eligible articles were included in the final analysis. Analysis was performed using a meta-analysis approach. The exact Clopper-Pearson confidence intervals, heterogeneity assessment, and random effects models with Mantel-Haenszel methods were employed using the STATA software version 14.2. RESULTS: The most prevalent causes of maternal deaths, listed in descending order from highest to lowest prevalence, were non-obstetric complications (48.32%), obstetric hemorrhage (17.63%), hypertensive disorders of pregnancy, childbirth, and the puerperium (14.01%), other obstetric complications (7.11%), pregnancy with abortive outcome (5.41%), pregnancy-related infection (5.26%), unanticipated complications of management (2.25%), unknown/undetermined causes (2.01%), and coincidental causes (1.59%), respectively. CONCLUSION: Non-obstetric complications, obstetric hemorrhage, and hypertensive disorders of pregnancy, childbirth, and puerperium were the most common causes of maternal deaths. To reduce the burden of maternal mortality causes, increasing awareness and promoting self-care management among women of reproductive age, and implementing effective screening mechanisms for high-risk mothers during pregnancy, childbirth, and the puerperium can play a significant role. ICD-MM enables the uniform collection and comparison of maternal death information at different levels (local, national, and international) by facilitating the consistent collection, analysis, and interpretation of data on maternal deaths. Our findings can be utilized by policymakers and managers at various levels to facilitate necessary planning aimed at reducing the burden of maternal mortality causes.

Study of The Relationship Between 24-hour Urine Protein Excretion Rate and Protein/Creatinine Ratio in Random Urine Specimen of Women with Preeclampsia.

INTRODUCTION: Early diagnosis and management of preeclampsia are very important to reduce fetal and maternal complications. In this study, we examined the ratio of protein to creatinine in a random urine sample and its relationship to the rate of 24-hour urine protein excretion for quick detection and prompt management of this condition in women with preeclampsia. METHODS: In this descriptive-analytical cross-sectional study, 60 pregnant women with preeclampsia referred to the maternity ward of Ali Ebn -e Abitaleb hospital of Zahedan in 2019 were recruited. The 24-hour urine protein excretion and the ratio of protein to creatinine in a random urine sample were compared in these patients. RESULTS: The results showed that there was a positive correlation between the 24-hour urinary protein excretion and the protein to creatinine ratio of the random urine sample in preeclampsia (P < .001, r = 0.515). Women with a higher 24-hour protein excretion also had a higher urinary protein to creatinine ratio. CONCLUSION: In general, based on the results of this study, it can be concluded that the ratio of protein to creatinine in the random urine sample has a good diagnostic efficiency in suspected preeclampsia. It is a quick alternative method for detecting suspicious proteinuria and could be used as a screening test in emergency situations.  DOI: 10.52547/ijkd.7457.

Incidence and exposure to microplastics in table salt present in the Iran market.

Plastics and microplastics (MPs) are toxic, pervasive and threatening the biotic and abiotic components of the earth, and they threaten food safety and food security by moving in the food chain. In this study, the amounts and characteristics of 40 table salt samples with different brands, including sea salt (No = 13), rock (No = 13), bulk (No = 8) and non-standard (No = 6), were investigated with a combination of sieving, filtration, observation and FTIR, Micro-Raman and SEM techniques. The results showed that all the salts were contaminated with MPs. In general, the abundance range of detected particles was 700-5470 MPs/kg. The abundance of MPs was higher in counterfeit and non-standard salts (1825 ± 1808 MPs/kg). Investigating the relationship between the effect of the purification process (Kruskal-Wallis Test, P = 0.841), the type of packaging (Kruskal-Wallis Test, P = 0.609), and the type of salt (Kruskal-Wallis Test, P = 0.942), on the abundance of MPs using a comparison test Kruskal-Wallis was not significant. However, the numerical difference was recognizable. The most identified polymer in the salts was cellulose acetate, which probably causes by unmanaged plastic litter in the environment (especially cigarette butts). The dominant form of particles was fragment-shaped, which is the most abundant form of identified MPs in the environment. Both environmental pollution and secondary pollution (during production and packaging), respectively, contribute to the contamination of salts with MPs. The estimated human dietary intake (EDI) and the amount of estimated annual intake (EAI) for different ages in Iran were obtained EDI = 5-59 MPs/capita/day and EAI = 1967-21563 MPs/capita/year. The surface morphology of the particles showed that the MPs were affected by continuous weathering, mechanical fracture and oxidation. MPs are a threat to human health due to the absorption and transmission of dangerous pollutants and their inherent toxicity. Therefore, a solution must be thought of to prevent the contamination of the food chain through salts by MPs, (with protective measures at the salt source, and by improving its production processes.

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines anddepression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial.

Background: The inflammation accelerates the progression of bipolar disorder. Supplementation of anti-inflammatory supplements in adjuvant with medications may alleviate disorder signs. This study aimed to investigate the effects of omega-3 fatty acid supplementation on the serum concentrations of pro-inflammatory cytokines and depression status in patients with bipolar disorder. Materials and Methods: This randomized clinical trial study was conducted in Zahedan city in 2021. Patients with bipolar disorder (n = 60) were grouped into two groups: omega-3 fatty acid supplement group (n = 30, 15 men and 15 women) and placebo one using a permuted block stratified randomization. The patients in the omega-3 group received 2 g of omega-3 fatty acids daily for 2 months while patients in the placebo group received 2 g soft gels daily in the same form. Depression score and the serum concentrations of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were assessed before and after the study. Results: Depression score and the serum concentrations of TNF-α, IL-6, and hs-CRP were decreased after intervention in the omega-3 fatty acid group also compared with the placebo group (P < 0.001). The results also show a positive correlation between the serum concentrations of TNF-α, IL-6, and hs-CRP with depression scores (P < 0.001). Conclusion: Prescription of omega-3 fatty acids can decrease inflammatory parameters and help to decrease depression in patients with bipolar disorder. This supplement can be used along with medications for decreasing the inflammatory markers in these patients.

Prevalence of celiac disease and its related factors in children aged 2-6 years old: A case-control study.

Background: Celiac disease (CD) is an immune-genetic disorder associated with the small intestine. Aim: The aim of this study was to determine the prevalence of CD and its related factors in children aged 2-6 years in southeastern Iran. Methods: In the present case-control research, the study groups were selected by convenience sampling method in Zahedan city, Sistan-and-Baluchestan province, southeastern Iran, from January 2021 till January 2022. Social-demographic status and personal information about the child, family, as well as the feeding pattern of children and mothers in the first six months of breastfeeding were examined. Frequency Food Questionnaire (FFQ) was also used for data collection. Results: The prevalence of CD was estimated at 9.2 per 10,000. Our findings showed that child age, birth weight, location of living, child birth type, child digestive disease, and child FFQ score played a significant role in the development of CD (p < 0.05). Children with CD consumed less bread and cereals, meat, eggs and legumes, dairy products, and fruits and vegetables (p = 0.004). In the first six months of breastfeeding, the mean intake of mothers with celiac children and mothers with healthy children was almost the same (p = 0.75). Conclusion: Nutrition in the first six months of lactation, gastrointestinal diseases, birth weight, and type of delivery played a significant role in causing CD in children aged 2-6 years, but mothers' diets in the first six months of lactation had no significant effect on CD incidence in their infants.

Effects of Educational Interventions on Dietary Adherence among Type 2 Diabetics in Zahedan: Using the Health Action Process Approach.

Background: Type 2 diabetes is the most common type of diabetes, and dietary adherence is a self-care practice. This research aims to improve dietary adherence among type 2 diabetics in Zahedan using the HAPA model. Methods: In this cross-sectional study, a total of 210 type 2 diabetics admitted to hospital clinics in Zahedan during summer 2022 were selected. The intervention group (n = 105) and the control group (n = 105) were from hospitals in Zahedan. Samples were selected by the simple random sampling method among the diabetics. After data collection using the demographic characteristics questionnaire and the Dietary Adherence Questionnaire and the HAPA model constructs questionnaire, the pre-test analysis was performed. One and three months after the educational intervention, the questionnaires on HAPA model constructs and self-care behavior were filled out by the patients. Next, data were analyzed using independent t-test, chi-square test, and the Shapiro-Wilk test in SPSS 23. Results: The results showed that all of the HAPA model constructs had significant differences, one and three months after the educational intervention (P = 0.001), indicating the effectiveness of education in the intervention group. However, there was no significant difference in the control group (P = 0.009). Conclusion: After the intervention using the HAPA model, the model's constructs had a significant impact on the patients' self-care of dietary adherence following the training.

Evaluation of the effect of melatonin in patients with Burning mouth syndrome: a double-blind, placebo-controlled randomized clinical trial

Abstract The present study was carried out to evaluate the effect of Melatonin and Placebo in the patient with the Burning mouth (BMs). This double-blind, placebo-controlled randomized clinical trial study was carried out on 30 patients who were suffering from BMS. During this period patients were divided into 2 study and control groups. The study group used four 3 mg Melatonin daily and the control group received a placebo. Then the severity of the burning sensation was measured by the physician Sleep quality was measured using the VAS scale using the Petersburg questionnaire. Data in the application Enter SPSS 20 and then using T test or equivalent Nonparametric was analyzed, mean sleep score and mean severity of oral irritation before and after treatment in two the group was evaluated using T-test Independent. Level significance was considered 0.05. The results of the present study show that the use of melatonin and a placebo in patients with BMS reduces sensation and improves their sleep quality, although it may not reduce it completely. In this study severity of burning was 4.93±2.56 after treatment in the study group and 6.93±2.12 in the control group, which was statistically significant (P =0.036). No significant difference was observed between the two groups in the sleep quality score (P-value = 0.43). Using Melatonin can be a reliable way to treat pain for which there is no standard treatment to date. Although evidence suggests an association between sleep disorders and BMS, melatonin was not superior to a placebo in reducing BMS-induced burning in the present study. Identification of stressors and the ways to struggle with them, further studies with larger samples and higher oral doses, extended follow-up periods and control of psychological factors, and measurement of body mass index that may affect pharmacokinetics are recommended.

Prevalence of Domestic Violence Against Women Undergoing Methadone Maintenance Therapy Programs and its Related Risk Factors.

Background: This study aimed to investigate the prevalence of domestic violence (DV) against women who are undergoing methadone maintenance therapy (MMT) and its related risk factors. Methods: This case-control study was conducted on 195 women who were under MMT and a control group consisting of 195 women who were not under it in the city of Zahedan from 22 May to 1 December 2019. Data were collected using a questionnaire for the measurement of violence against women and a sociodemographic questionnaire. In order to analyze the data, the t test, analysis of variance (ANOVA), Pearson's correlation, and multiple regression analysis were used. Findings: In the case group, 67.2% of participants had experienced DV during the past year. In the control group, the prevalence was 78.5%. The rate of more than one occasion of DV was significantly higher in the group who were under MMT (P<0.05). The most common type of violence was mental abuse. Physical, sexual, and economic abuses were in the next ranks. Important predictors of DV, in order of importance, were: the women's low educational level, smoking, income level, and polygamy (P<0.05). Conclusion: MMT is not a risk factor for DV. It seems that the rate of DV against women in Zahedan is very high. The prevalence of recurrent DV in women under MMT was higher than in the general population.

Quality of death certificates completion for COVID-19 cases in the southeast of Iran: A cross-sectional study.

Background and Aim: Death certificate (DC) data provides a basis for public health policies and statistics and contributes to the evaluation of a pandemic's evolution. This study aimed to evaluate the quality of the COVID-19-related DC completion. Methods: A descriptive-analytical study was conducted to review a total of 339 medical records and DCs issued for COVID-19 cases from February 20 to September 21, 2020. A univariate analysis (χ 2 as an unadjusted analysis) was performed, and multiple logistic regression models (odd ratio [OR] and 95% confidence interval [CI] as adjusted analyses) were used to evaluate the associations between variables. Results: Errors in DCs were classified as major and minor. All of the 339 examined DCs were erroneous; more than half of DCs (57.8%) had at least one major error; all of them had at least one minor error. Improper sequencing (49.3%), unacceptable underlying causes of death (UCOD) (33.3%), recording more than one cause per line (20.1%), listing general conditions instead of specific terms (11.2%), illegible handwriting (8.3%), competing causes (6.2%), and mechanisms (3.8%) were most common major errors, respectively. Absence of time interval (100%), listing mechanism allying with UCOD (51.6%), using abbreviations (45.4%), missing major comorbidities (16.5%), and listing major comorbidities in part I (16.5%) were most common minor errors, respectively. Conclusion: The rate of both major and minor errors was high. Using automated tools for recording and selecting death cause(s), promoting certifiers' skills on DC completion, and applying quality control mechanisms in DC documentation can improve death data and statistics.

Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene.

Printing workers (PWs) are exposed to a mixture of solvents, yet the health risks associated with such exposuer are unknown. This study aimed to compare the serum levels of selected biomarkers of oxidative stress among occupationally exposed PWs to low-level of toluene and xylenes and unexposed controls. Associations between levels of such biomarkers and occupational exposures to toluene and xylene were also investigated. Urinary levels of hippuric acid (HA) and methyl hippuric acids (MHAs) as exposure biomarkers of toluene and xylenes, respectively, and serum levels of oxidative stress biomarkers, including total antioxidant capacity (TAC), malondialdehyde (MDA), and the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were measured among the 84 subjects, comprising 44 PWs and 40 unexposed subjects. Mean concentrations of urinary HA and MHAs of PWs showed a significant increase compared with the unexposed controls. Although levels of urinary biomarkers of exposure to toluene (HA) and xylenes (MHAs) were well below the biological exposure indices (BEIs; ACGHI), PWs presented significantly increased serum levels of MDA, and significantly decreased serum activities of SOD and GPx compared to the unexposed controls. However, for serum TAC and CAT activity, no significant difference was observed between the two groups. Correlation analyses indicated that urinary levels of HA and MHAs were positively correlated with MDA levels and negatively correlated with GPx and SOD. Our study suggested that the alterations evidenced in serum levels of MDA, SOD, and GPx could be involved in the oxidative stress caused by co-exposure to low levels of toluene and xylene. Further investigation is needed to clarify the effect of low-level occupational exposure to solvents among PWs.

Effect of proximal exercises of lower extremity on static balance parameters during quiet standing.

Purpose: People who suffer from knee osteoarthritis (KOA) face reduced balance, which causes increased falling and many serious complications and injuries. The purpose of the extant study was to determine the effect of proximal exercises of lower extremity on static balance parameters during quiet standing. Materials and Methods: In the present randomized controlled trial, 36 patients were divided into intervention and control groups (n = 18 in each group). Both groups received routine physiotherapy in three sessions per week for 6 weeks, while the intervention group did proximal exercises in addition to physiotherapy routine. In the extant study, the pain intensity was measured through a visual analog scale (VAS), and individuals' static balance parameters were measured using Biodex Balance System. All measurements were done before and after the intervention, and then statistical data analysis was performed with Statistical Package for the Social Sciences (SPSS) 24 software. Results: Intergroup comparison indicated significant progress of pain intensity, anterior-posterior (AP), and Overall balance stability in both studied groups (P < 0.05). There was a significant increase in medial-lateral (ML) balance stability only in the intervention group (P < 0.05). Intergroup comparison showed that there was not any significant difference between variables before the intervention (P > 0.05). The results showed more progress in the intervention group than the control group after they received the intervention, which was significant in terms of ML balance stability (P < 0.05). Conclusion: Adding proximal exercises to physiotherapy had more effect on ML balance stability in KOA patients; however, 6 weeks of these exercises in addition to physiotherapy had also the same effect on pain intensity, Overall, and AP balance stability.

Common errors in reporting cause-of-death statement on death certificates: A systematic review and meta-analysis.

The prevalence of death certificate (DC) completion errors is a universal issue. This research aimed to estimate the global prevalence of DC errors by performing a systematic review and meta-analysis. Databases including Web of Science, PubMed, Science Direct, Scopus, and Google search engine were searched by September 4, 2020. Thirty-five articles were included in the final analysis. The exact Clopper-Pearson confidence intervals, heterogeneity assessment, random effects models with Mantel-Haenszel methods were employed using STATA version 14.2 software. Absence of time interval (80.9%), absence/inappropriateness of comorbidities (45.1%), incorrect underlying cause-of-death (COD) statement (38.9%), improper sequence (36.2%), mechanism of death with underlying COD (UCOD) (33.6%), abbreviations (33.0%), mechanism only (23.9%), competing causes (21.5%), two or more condition per line (19.3%), incorrect COD (18.0%), nonspecific or ill-defined condition (16.4%), blanks/repetitive phrases (12.5%), and illegible handwriting (11.6%) were the most prevalent errors, respectively. Lack of or poor training/educating of certifiers, lack of physician understandings about the importance of DC and absence of quality assurance mechanisms were identified as the most significant causes of DC errors. Furthermore, providing ongoing, targeted and interactive training/education, and establishment of quality control and tracking mechanisms for completion of deficient DCs were suggested as the important improving solutions.

Validation and Normalization of Grasha-Riechmann Teaching Style Inventory in Faculty Members of Zahedan University of Medical Sciences.

INTRODUCTION: Considering the importance of teaching styles and their impact on promoting higher education, and the lack of a valid and reliable tool in universities of medical sciences for measuring this concept, as well as no instruments normalized for Faculty of Medical Sciences, the aims of this study were to 1) evaluate and normalize Grasha-Riechmann Teaching Style Inventory and 2) determine the teaching style of the faculty members of Zahedan University of Medical Sciences during 2018-2019. MATERIALS AND METHODS: This was a methodological study. In order to carry out this study, Grasha-Riechmann Teaching Style Inventory was translated and culturally adopted. To measure validity, reliability, and normalize the questionnaire, it was distributed among the study population composed of 361 faculty members (instructor, assistant professor, associate professor, and professor) who were taught theoretical and practical courses in Zahedan University of Medical Sciences, Zahedan, Iran, during the academic year 2018-2019. Confirmatory factor analysis (CFA) and Cronbach's alpha using SPSS version 16 were used to analyze the data. RESULTS: The results of data analysis showed that of the 361 participants, 212 were men and 149 were women. The mean age of the participants was 42.52 ± 7.72 years and their average work experience was 10.12 ± 7.61 years. Content validity was calculated using content validity index (CVI) and content validity ratio (CVR) for each item, and it was reported 97.4 and 68.5, respectively. Cronbach's alpha was used to determine the internal consistency, and its value was 95%. The construct validity of the Grasha-Riechmann Teaching Style Inventory was assessed using CFA by EQS version 6.1. The value of root mean square error of approximation (RMSEA) was 0.075 with the 90% confidence interval, and the GFI value was 0.74. The mean scores and standard deviations (SD) of teaching styles were 5.61 ± 0.61 for Expert teaching style, 5.23 ± 0.72 for formal authority teaching style, 5.39 ± 0.66 for personal model teaching style, 5.43±0.71 for facilitator teaching style, and 4.99 ± 0.82 for delegator teaching style. Our results suggested dominance of the expert (88.6%) and delegator (79.8%) teaching styles as well as the modest use of personal model (65.9%), formal authority (59.3%), and facilitator (55.7%) teaching styles among the faculty members of Zahedan University of Medical Sciences. DISCUSSION: The results of the current study will be effective in promoting education level and increasing students' satisfaction with the academic courses. Researchers and those interested in university medical education and development centers can benefit from the results of this study. For the first time, the psychometric test (normalizing and validating) of Grasha-Riechmann Teaching Style Inventory has been carried out at Zahedan University of Medical Sciences. Also, this questionnaire has been applicable to determine teaching styles of faculty members. CONCLUSION: Overall, the results of the present study showed that the Grasha-Riechmann teaching Style Inventory had a good internal consistency and can be used as a valid tool for evaluating teachers' teaching style.

The Complaints, Type, and Severity of Stressful Events in Patients with Burning Mouth Syndrome Referring to Zahedan School of Dentistry, Iran.

INTRODUCTION: Burning mouth syndrome (BMS) is a burning sensation in oral mucosa without visible lesions in clinical examinations. The present study aimed at comparing complaints, frequency, type, and severity of stressful events between patients with BMS and healthy individuals referred to Zahedan School of Dentistry, Zahedan, Iran. MATERIALS AND METHODS: In the present study, 30 patients with BMS were matched with controls by age and gender after enrollment. The Holmes-Rahe questionnaire and the complaint registration form were used to compare the frequency of complaints, and the type and severity of stressful events between the groups. Data were analyzed by descriptive statistics, Chi-squared and t-tests. RESULTS: The mean age of the subjects in the case and control groups was 40.13 ± 2.30 and 40.07 ± 2.31 years, respectively. The obtained results showed no statistically significant difference between the groups in terms of mean age and gender distribution (P>0.05). The results of the Chi-squared test showed a significant difference in the frequency of complaints between the two groups (P<0.001). The t-test results indicated that the average severity of complaints and the average severity of stressful events were significantly different between patients with BMS and controls (P<0.001). The results of Chi-squared test revealed that the mean frequency of complaints (P<0.001) and mean frequency of stressful events (P<0.001) were significantly different between the two groups. CONCLUSIONS: Based on the study results, the frequency of complaints, and the type and severity of stressful events were significantly different between patients with BMS and healthy individuals referred to the clinic of Zahedan School of Dentistry.

Multiparametric MRI for the Diagnosis of Tumor Type in Patients Suspicious of Inner Gland Prostate Cancer.

PURPOSE: The current study aimed to evaluate multiparametric MRI for the diagnosis of type of tumor (benign ormalignant) in patients suspicious of inner gland prostate cancer. MATERIALS AND METHODS: This cross-sectional study was conducted on 44 consecutive patients with a clinicalimpression of prostate cancer who were referred to the MRI department of Payambaran Hospital, Tehran, Iranfor confirmative diagnostic evaluation. Cases suspected of tumor relapse and those who previously underwenttreatment for prostate cancer were excluded. Multiparametric MRI was performed for every patient by using a 1.5Tesla device with an integrated endorectal and pelvic-phased array coil. All patients subsequently underwent MRItransrectalultrasound fusion biopsy. The diagnostic value of each sequence was then investigated individually andin combination with other techniques by comparing the results with histological findings from MRI-TRUS fusionbiopsy. RESULTS: Among the techniques, T2-weighted imaging (T2W) had the highest sensitivity and specificity whiledynamic contrast enhanced (DCE) technique had the least. Diffusion-weighted imaging (DWI) and magnetic resonancespectroscopy (MRS) had a similar sensitivity and specificity and did not significantly differ from T2W.Adding functional techniques to T2W did not improve diagnostic indices compared to T2W alone. Quantitativeevaluation of apparent diffusion coefficient (ADC), DWI, and MRS showed that all techniques were able to differentiatebetween benign and malignant tumors. However, the quantitative combination of these sequences decreaseddiagnostic performance. CONCLUSION: T2W is the best technique for the diagnosis of type of tumor in terms of benignancy or malignancyin patients suspicious of inner gland prostate cancer. Adding functional imaging measurements to T2W does notimprove its diagnostic value.

Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial.

TRIAL REGISTRATION:: Iranian Registry of Clinical Trials Registration Number: IRCT2016061228407N1 ( www.who.int/ictrp/network/irct/en/ ).

Optimisation of chemical oxygen demand removal from landfill leachate by sonocatalytic degradation in the presence of cupric oxide nanoparticles.

Leachate is the liquid formed when waste breaks down in the landfill and water filters through that waste. This liquid is very toxic and can pollute the land, ground water, and water resources. In most countries, it is mandatory for landfills to be protected against leachate. In addition to all other harms to the environment, disposal of raw landfill leachate can be a major source of hazard to closed water bodies. Hence, treatment of landfill leachate is considered an essential step prior to its discharge from source. This article describes the sonocatalytic degradation of chemical oxygen demand in landfill leachate using cupric oxide nanoparticles as sonocatalyst (cupric oxide/ultrasonic) and aims to establish this method as an effective alternative to currently used approaches. An ideal experimental design was carried out based on a central composite design with response surface methodology. The response surface methodology was used to evaluate the effect of process variables including pH values (3, 7, 11), cupric oxide nanoparticles dose (0.02, 0.035, 0.05 g), reaction time (10, 35, 60 minutes), ultrasonic frequency (35, 37, 130 KHz), and their interaction towards the attainment of their optimum conditions. The derived second-order model, including both significant linear and quadratic terms, seemed to be adequate in predicting responses (R2 = 0.9684 and prediction R2 = 0.9581). The optimum conditions for the maximum chemical oxygen demand sonocatalytic degradation of 85.82% were found to be pH 6.9, cupric oxide nanoparticles dosage of 0.05 gr L-1, and the ultrasonic frequency of 130 kHz at a contact time of 10 min.

Prevalence of malnutrition among preschool children in northeast of Iran, a result of a population based study.

INTRODUCTION: Malnutrition in preschool children is a significant problem and has been identified by the World Health Organization (WHO) as the most lethal form of malnutrition, indirectly or directly causes an annual death of at least 5 million children worldwide. The object of this study was to estimated the rate of underweight, stunting and wasting among preschool children in northeast of Iran. METHODS: A cross sectional population based study was conducted and 70339 children; 35792 males and 34547 females were recruited. The primary outcome variables were; weight, height, age and gender of the children. The sex and age specific rate and overall rate of underweight, stunting, and wasting were calculated. RESULTS: The rate of underweight, stunting, and wasting were 7.5%, 12.5% and 4.4% respectively. There were significant differences in stunting and wasting rate between boys and girls. The overall rate of stunting was significantly higher than the overall rates of underweight and wasting. The rate of malnutrition increased with child's age. CONCLUSION: In compare to WHO criteria, the rate of malnutrition among this study population was low. According to the higher rate of stunting, the main goal of future research and interventions must be finding the causes of deficiency in height growth and improving it.