Structural composite based on 3D printing polylactic acid/carbon fiber laminates (PLA/CFRC) as an alternative material for femoral stem prosthesis.

In recent years, surgical procedures for hip prostheses have increased. These implants are manufactured with materials with high stiffness compared to the bone, causing bone loss or aseptic loosening. This research proposes an alternative structural composite consisting of 3D-printing polylactic acid layers and carbon fiber laminates (PLA/CFRC) with potential application in prosthetic implants. Fourier-transform infrared spectroscopy (FTIR) achieved to characterize starting materials and structural composites revealed secondary chemical interactions between the carbonyl group of PLA with the hydroxyl group of epoxy resin from CFRC. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) results show both components (PLA and CFRC) influence the structural composite's thermal behavior, observed in the temperatures of degradation, glass transition, and melting. Furthermore, the composite reached cell viability above 80%, a tensile modulus of 19.29 ± 0.48 GPa and tensile strength of 238.91 ± 25.95 MPa, with mechanical properties very similar to the bone. The results of this study demonstrated that the proposed PLA/CFRC composite can be used as candidate base material for the manufacturing of a hip femoral stem prostheses.

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings.

Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al2O3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58-60 °C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al2O3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al2O3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.

Synthetic hydroxyapatite and its use in bioactive coatings.

An approach to solve the limitations of autologous bone grafting procedures in bone injury treatment is to develop bioactive coatings in the implantation system. The objective of this work is to compare the temperature effect on the stability of hydroxyapatite, graphene, and collagen colloidal suspensions to be used as biocompatible and bioactive coatings on a carbon fiber composite surface. Synthesized hydroxyapatite was assessed by X-ray diffraction. Zeta potential at different temperatures was evaluated. Specimens were characterized using scanning electron microscopy and Raman analysis. The results showed that the best hydroxyapatite/graphene ratio was 85/15, while those of the hydroxyapatite/collagen mixtures were 85/15. A hydroxyapatite/graphene/collagen mixture was synthesized based on these results.