RESUMO
INTRODUCTION: The relationship between epilepsy and music is poorly understood. Musicogenic epilepsy, which involves seizures triggered by music, and epilepsy that triggers or involves musical experiences are rare. Anti-seizure medications (ASMs) may affect cognition and possibly the musical sphere. The relationship between epilepsy, ASMs and music perception is insufficiently investigated in the literature. This study describes the clinical characteristics of patients with epilepsy with advanced musical knowledge, and aims to understand the disease's involvement in the musical sphere. PATIENTS AND METHODS: A qualitative study was conducted in epileptic patients with musical knowledge, investigating their musical perception before and after a diagnosis of epilepsy and after a change of ASM when this was possible. Questionnaires and recordings of music were used to assess musical perception. RESULTS: Fourteen patients had musical knowledge, and the majority of these (50%) had temporal lobe epilepsy. A total of 92.8% of the patients stated that epilepsy or its medications had affected them in the musical sphere. There was no clear relationship between the lateralisation of the epilepsy and musical involvement. 42.9% were professional musicians, and had to give up their profession. The patients prescribed with more than one ASM had greater musical involvement. CONCLUSIONS: Temporal lobe epilepsy appears to have the greatest effect on music perception, and more studies with ASM and music perception are needed to determine its effects.
TITLE: Epilepsia y percepción musical. Una visión a través de 14 pacientes.Introducción. La relación entre la epilepsia y la música es poco comprendida. La epilepsia musicógena, que involucra crisis desencadenadas por la música, y la epilepsia que produce o involucra experiencias musicales son poco comunes. Se sabe que los medicamentos anticrisis (MAC) pueden afectar a la cognición y posiblemente a la esfera musical. La relación entre la epilepsia, los MAC y la percepción musical está insuficientemente investigada en la bibliografía. El objetivo de este estudio es describir las características clínicas de pacientes con epilepsia con conocimientos musicales avanzados e intentar comprender la afectación de la enfermedad a la esfera musical. Pacientes y métodos. Se llevó a cabo un estudio cualitativo en pacientes epilépticos con conocimientos musicales, investigando su percepción musical antes y después del diagnóstico de epilepsia y, cuando fue posible, tras el cambio de MAC. Se utilizaron cuestionarios y grabaciones musicales para evaluar la percepción musical. Resultados. Catorce pacientes tenían conocimientos musicales, la mayoría (50%) con epilepsia del lóbulo temporal. Un 92,8% de los pacientes indicó que la epilepsia o sus medicamentos le habían afectado en la esfera musical. No había una clara relación entre lateralización de la epilepsia y afectación musical. Un 42,9% eran músicos profesionales y tuvieron que dejar la profesión. Los pacientes con más de un MAC pautado tenían mayor afectación musical. Conclusiones. La epilepsia del lóbulo temporal parece ser la que más afecta a la percepción musical, y hacen falta más estudios con MAC y percepción musical para dilucidar sus efectos.
Assuntos
Percepção Auditiva , Epilepsia , Música , Humanos , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Epilepsia/psicologia , Epilepsia/tratamento farmacológico , Adulto Jovem , Anticonvulsivantes/uso terapêutico , Pesquisa Qualitativa , Epilepsia do Lobo Temporal/psicologia , Epilepsia do Lobo Temporal/fisiopatologia , Epilepsia do Lobo Temporal/tratamento farmacológicoRESUMO
INTRODUCTION: Epileptic seizures are a common cause of admission in emergency services at hospitals. Performing the correct diagnosis can be difficult, and deciding when and which anti-seizure medication (ASM) to prescribe is critical. Our objective is to detail the characteristics of patients treated in a medium-sized hospital for this reason. PATIENTS AND METHODS: A retrospective observational study was performed, including all the adult patients treated by the emergency service of the Lucus Augusti University Hospital between January 2022 and January 2023 with a diagnosis of epileptic seizure on discharge. The study recorded their demographic variables, history, whether it was their first seizure, the number of seizures, whether an anti-seizure medication was administered and which one, the diagnosis, the tests performed, and whether the patient was referred to the neurology service. RESULTS: A total of 122 patients were diagnosed with epileptic seizures in the emergency service. 50.8% of the patients were women. The mean age was 69.8 years. Neurological assessment was requested for 47.6%. 50.8% presented their first seizure. No diagnosis was performed in 46% of the cases, of which only 10 were evaluated by the neurology service. The most common etiology was vascular. An electroencephalogram was performed on 41.8%. Levetiracetam was practically the only drug administered when the neurology department was not consulted. CONCLUSIONS: Early evaluation of patients with their first seizure in the emergency service by a neurological specialist is crucial for the diagnosis of epilepsy. The same anti-seizure medication is almost always prescribed when no cross-consultation takes place.
TITLE: Crisis en urgencias: una vista a las características clínicas y terapéuticas a través de 122 pacientes.Introducción. Las crisis epilépticas son un motivo frecuente de consulta en los servicios de urgencias hospitalarias. Llegar al diagnóstico correcto puede ser complejo, y es fundamental decidir cuándo y qué medicamento anticrisis (MAC) pautar. Nuestro objetivo es detallar las características de los pacientes que consultaron por este motivo en un hospital mediano. Pacientes y métodos. Estudio observacional retrospectivo de todos los pacientes mayores de edad que consultaron en el servicio de urgencias del Hospital Universitario Lucus Augusti entre enero de 2022 y enero de 2023 con diagnóstico al alta de crisis epiléptica. Se registraron variables demográficas, los antecedentes, si era una primera crisis, el número de éstas, si se inició un MAC y cuál, el diagnóstico, qué pruebas se realizaron y si se interconsultó con la guardia de neurología. Resultados. Se diagnosticó a 122 pacientes de crisis epilépticas en urgencias. El 50,8% eran mujeres. La media de edad fue de 69,8 años. Se solicitó valoración por neurología en un 47,6%. El 50,8% presentó una primera crisis. No se llegó al diagnóstico en un 46% de los casos, de los cuales sólo 10 fueron valorados por neurología. La etiología más frecuente fue la vascular. Se realizó un electroencefalograma en un 41,8%. El levetiracetam fue prácticamente el único fármaco utilizado cuando no se consultó con neurología. Conclusiones. La valoración precoz de los pacientes con una primera crisis en urgencias por un especialista en neurología es determinante para el diagnóstico de epilepsia. Cuando no se interconsulta, casi siempre se pauta el mismo MAC.
Assuntos
Serviços Médicos de Emergência , Adulto , Humanos , Feminino , Idoso , Masculino , Eletroencefalografia , Hospitalização , Hospitais Universitários , Convulsões/diagnóstico , Convulsões/tratamento farmacológicoRESUMO
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Masculino , Feminino , Gravidez , Lactente , Humanos , Fenilcetonúria Materna/complicações , Deficiência Intelectual/etiologia , Fenilcetonúria Materna/diagnóstico , Microcefalia/etiologia , Doenças Fetais/diagnóstico , Doenças Fetais/etiologia , Fenilalanina/sangue , Espectroscopia de Ressonância Magnética , EletroencefalografiaAssuntos
Retardo do Crescimento Fetal/etiologia , Comunicação Interventricular/etiologia , Doenças do Prematuro/etiologia , Deficiência Intelectual/etiologia , Microcefalia/etiologia , Fenilcetonúrias/metabolismo , Complicações na Gravidez/metabolismo , Desenvolvimento Embrionário , Fácies , Feminino , Comunicação Interventricular/embriologia , Humanos , Lactente , Recém-Nascido , Doenças do Prematuro/embriologia , Deficiência Intelectual/embriologia , Masculino , Troca Materno-Fetal , Microcefalia/embriologia , Fenilalanina/efeitos adversos , Fenilalanina/metabolismo , Fenilcetonúrias/genética , Gravidez , Complicações na Gravidez/genéticaRESUMO
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Masculino , Adolescente , Humanos , Síndrome de Beckwith-Wiedemann/complicações , Epilepsia/etiologia , Anticonvulsivantes/uso terapêutico , Epilepsia/tratamento farmacológicoAssuntos
Anti-Inflamatórios não Esteroides/administração & dosagem , Indometacina/administração & dosagem , Hemicrania Paroxística/tratamento farmacológico , Hemicrania Paroxística/fisiopatologia , Doenças do Nervo Troclear/tratamento farmacológico , Doenças do Nervo Troclear/fisiopatologia , Feminino , Humanos , Pessoa de Meia-Idade , Órbita , Hemicrania Paroxística/etiologia , Nervo Troclear/fisiopatologia , Doenças do Nervo Troclear/complicaçõesAssuntos
Arteriopatias Oclusivas/etiologia , Arterite de Células Gigantes/complicações , Insuficiência Vertebrobasilar/etiologia , Idoso , Arteriopatias Oclusivas/complicações , Biópsia , Arterite de Células Gigantes/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/patologia , Artérias Temporais/patologia , Insuficiência Vertebrobasilar/complicações , Insuficiência Vertebrobasilar/patologiaAssuntos
Dissecação da Artéria Carótida Interna/complicações , Doenças do Nervo Hipoglosso/etiologia , Adulto , Dissecação da Artéria Carótida Interna/diagnóstico , Dissecação da Artéria Carótida Interna/patologia , Humanos , Doenças do Nervo Hipoglosso/diagnóstico , Doenças do Nervo Hipoglosso/patologia , Masculino , RecidivaRESUMO
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Masculino , Humanos , Dissecação da Artéria Carótida Interna/complicações , Dissecação da Artéria Carótida Interna/epidemiologia , Dissecação da Artéria Carótida Interna/etiologia , Doenças do Nervo Hipoglosso/complicações , Inibidores da Agregação Plaquetária/administração & dosagem , Recidiva , Dissecação da Artéria Carótida Interna/patologia , Doenças do Nervo Hipoglosso/tratamento farmacológico , Artérias Carótidas/fisiopatologia , Cervicalgia/etiologia , Cefaleia/etiologia , Ticlopidina/uso terapêutico , Síndrome de Horner/patologia , Imageamento por Ressonância Magnética , Neurologia , Isquemia Encefálica/etiologiaRESUMO
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Humanos , Arterite de Células Gigantes/complicações , Arterite de Células Gigantes/diagnóstico , Arterite de Células Gigantes/prevenção & controle , Acidente Vascular Cerebral/etiologia , Anemia/sangue , Aneurisma/etiologia , Estudos Epidemiológicos , InflamaçãoAssuntos
Transtornos Cerebrovasculares/etiologia , Arterite de Células Gigantes/complicações , Arterite de Células Gigantes/diagnóstico , Transtornos Cerebrovasculares/diagnóstico , Transtornos Cerebrovasculares/prevenção & controle , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de RiscoRESUMO
Primary intraventricular hemorrhage is very rare in adults and is even more infrequent in children. We present a 15-year-old girl who presented to the hospital because of sudden severe headache, vomiting and fever. Neurological examination only showed neck stiffness. A brain computed tomography showed blood in the ventricular system. Conventional angiography revealed an arteriovenous malformation originating in the right pericallosal artery branches. Gamma-knife radiosurgery was performed without relevant complications. A follow-up cerebral angiography showed disappearance of the arteriovenous malformation. When a primary intraventricular hemorrhage is detected in a young patient it is mandatory to rule out an underlying lesion such an arteriovenous malformation. Treatment options include surgery, interventional radiology and radiosurgery, alone or in combination.
Assuntos
Hemorragia Cerebral/etiologia , Malformações Arteriovenosas Intracranianas/complicações , Adolescente , Feminino , Humanos , Malformações Arteriovenosas Intracranianas/diagnóstico , Malformações Arteriovenosas Intracranianas/terapiaAssuntos
Lesões das Artérias Carótidas/etiologia , Dissecação da Artéria Carótida Interna/etiologia , Artéria Carótida Interna/fisiopatologia , Infarto da Artéria Cerebral Média/etiologia , Natação/lesões , Ferimentos e Lesões/etiologia , Acidentes , Fenômenos Biomecânicos , Concussão Encefálica/etiologia , Concussão Encefálica/patologia , Concussão Encefálica/fisiopatologia , Lesões das Artérias Carótidas/patologia , Lesões das Artérias Carótidas/fisiopatologia , Artéria Carótida Interna/patologia , Dissecação da Artéria Carótida Interna/patologia , Dissecação da Artéria Carótida Interna/fisiopatologia , Disartria/etiologia , Disartria/patologia , Disartria/fisiopatologia , Humanos , Hipestesia/etiologia , Hipestesia/patologia , Hipestesia/fisiopatologia , Infarto da Artéria Cerebral Média/patologia , Infarto da Artéria Cerebral Média/fisiopatologia , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Água do Mar/efeitos adversos , Ferimentos e Lesões/patologia , Ferimentos e Lesões/fisiopatologiaRESUMO
La hemorragia intraventricular primaria es rara en pacientes adultos. En niños y adolescentes es todavía más infrecuente. Se presenta una paciente de 15 años de edad que acudió al hospital por cefalea intensa de inicio súbito, vómitos y febrícula. La exploración neurológica fue normal, salvo marcada rigidez de nuca. La TC cerebral mostró la presencia de sangre en el sistema ventricular. La angiografía cerebral evidenció una malformación arteriovenosa alimentada por ramas de la arteria pericallosa derecha. Se realizó radiocirugía de esta sin complicaciones relevantes. Una angiografía cerebral de control realizada 2 años después del episodio de hemorragia mostró desaparición de la malformación. La presencia de una hemorragia intraventricular primaria en pacientes jóvenes obliga a descartar la existencia de una lesión subyacente como una malformación arteriovenosa. Las opciones terapéuticas en estos casos son la cirugía, la embolización y la radiocirugía solas o en combinación
Primary intraventricular hemorrhage is very rare in adults and is even more infrequent in children. We present a 15-year-old girl who presented to the hospital because of sudden severe headache, vomiting and fever. Neurological examination only showed neck stiffness. A brain computed tomography showed blood in the ventricular system. Conventional angiography revealed an arteriovenous malformation originating in the right pericallosal artery branches. Gamma-knife radiosurgery was performed without relevant complications. A follow-up cerebral angiography showed disappearance of the arteriovenous malformation. When a primary intraventricular hemorrhage is detected in a young patient it is mandatory to rule out an underlying lesion such an arteriovenous malformation. Treatment options include surgery, interventional radiology and radiosurgery, alone or in combination
Assuntos
Feminino , Adolescente , Humanos , Hemorragia Cerebral/etiologia , Malformações Arteriovenosas Intracranianas/complicações , Malformações Arteriovenosas Intracranianas/diagnóstico , Malformações Arteriovenosas Intracranianas/terapiaRESUMO
The present work describes for the first time the anatomical distribution of adrenocorticotropic hormone (ACTH) in the diencephalon and the brainstem of the dog by means of the indirect immunoperoxidase technique. The distribution found in this species agrees well with the pattern found in other mammals and particularly confirms much of the findings reported in the cat. An exception to that concordance is the presence of ACTH perikarya in the nucleus of the solitary tract of the dog, a population that has been described in the rat but not in the cat, and in the ventral mesencephalon. This last population spread across the ventral tegmental area from the raphe to the cerebral peduncle and appeared to be a specific feature of the canine brain. On the other hand, we can not see ACTH fibers in the substantia nigra of the dog which could be a characteristic of the domestic carnivores, opposite to rodents, since these fibers appeared to be also lacking in the cat. Nevertheless, the widespread distribution of ACTH fibers in the brain of the dog included many other nuclei containing monoaminergic neurons which supported a possible role for ACTH in the regulation of these neurotransmitter systems.
Assuntos
Hormônio Adrenocorticotrópico/metabolismo , Tronco Encefálico/metabolismo , Diencéfalo/metabolismo , Cães/metabolismo , Neurônios/metabolismo , Animais , Monoaminas Biogênicas/metabolismo , Mapeamento Encefálico , Tronco Encefálico/citologia , Diencéfalo/citologia , Cães/anatomia & histologia , Imuno-Histoquímica , Masculino , Neurônios/citologia , Núcleo Solitário/citologia , Núcleo Solitário/metabolismo , Especificidade da Espécie , Substância Negra/citologia , Substância Negra/metabolismo , Área Tegmentar Ventral/citologia , Área Tegmentar Ventral/metabolismoRESUMO
OBJECTIVE: To examine the frequency and predictors of cerebrovascular accidents (CVA) in giant cell arteritis (GCA) patients from a defined population. METHODS: Retrospective study of biopsy-proven GCA patients diagnosed from 1981 through 2001 at the single hospital for the population of Lugo (Northwest Spain). RESULTS: Thirty (14.3%) of the 210 biopsy-proven GCA patients had CVA, 5 of them (16.7%) involving the vertebrobasilar territory. Five patients (4 of them involving the carotid territory) had CVA within the 2 years prior to the onset of GCA symptoms. Four patients had CVA within the first month after the diagnosis of the disease. Of these, 3 involved the vertebrobasilar territory. Another 5 patients suffered carotid stroke between the 4th and the 12th month after the disease diagnosis. The remaining 16 GCA patients had CVA (all but one involving the carotid territory) at least 1 year after the diagnosis of vasculitis. No differences in the clinical and laboratory features at the time of diagnosis between patients who had CVA and the rest of the biopsy-proven GCA patients were observed. However, hypertension and hyperlipidemia at the time of diagnosis of GCA were associated with the development of CVA (p < 0.05 for both). Also, anemia at the time of diagnosis (hemoglobin < 12 g/dL) [hazard ratio = 0.34 (95% CI 0.12 - 1.00; p = 0.05)] was negatively associated with CVA within the first 10 years after the diagnosis of the disease. Mortality in GCA patients with CVA was not significantly higher than that in patients without CVA (hazard ratio = 1.53; p = 0.14). CONCLUSION: The present study confirms that CVA may occur in GCA. Vertebrobasilar accidents are more common than carotid accidents at the time of diagnosis of the disease. Vascular risk factors should be carefully controlled in the follow-up of GCA patients.