Gelatin Methacryloyl (GelMA) - 45S5 Bioactive Glass (BG) Composites for Bone Tissue Engineering: 3D Extrusion Printability and Cytocompatibility Assessment Using Human Osteoblasts.

3D extrusion printing has been widely investigated for low-volume production of complex-shaped scaffolds for tissue regeneration. Gelatin methacryloyl (GelMA) is used as a baseline material for the synthesis of biomaterial inks, often with organic/inorganic fillers, to obtain a balance between good printability and biophysical properties. The present study demonstrates how 45S5 bioactive glass (BG) addition and GelMA concentrations can be tailored to develop GelMA composite scaffolds with good printability and buildability. The experimental results suggest that 45S5 BG addition consistently decreases the compression stiffness, irrespective of GelMA concentration, albeit within 20% of the baseline scaffold (without 45S5 BG). The optimal addition of 2 wt % 45S5 BG in 7.5 wt % GelMA was demonstrated to provide the best combination of printability and buildability in the 3D extrusion printing route. The degradation decreases and the swelling kinetics increases with 45S5 BG addition, irrespective of GelMA concentration. Importantly, the dissolution in simulated body fluid over 3 weeks clearly promoted the nucleation and growth of crystalline calcium phosphate particles, indicating the potential of GelMA-45S5 BG to promote biomineralization. The cytocompatibility assessment using human osteoblasts could demonstrate uncompromised cell proliferation or osteogenic marker expression over 21 days in culture for 3D printable 7.5 wt % GelMA -2 wt % 45S5 BG scaffolds when compared to 7.5 wt % GelMA. The results thus encourage further investigations of the GelMA/45S5 BG composite system for bone tissue engineering applications.

Eye Gaze Guided Cross-Modal Alignment Network for Radiology Report Generation.

The potential benefits of automatic radiology report generation, such as reducing misdiagnosis rates and enhancing clinical diagnosis efficiency, are significant. However, existing data-driven methods lack essential medical prior knowledge, which hampers their performance. Moreover, establishing global correspondences between radiology images and related reports, while achieving local alignments between images correlated with prior knowledge and text, remains a challenging task. To address these shortcomings, we introduce a novel Eye Gaze Guided Cross-modal Alignment Network (EGGCA-Net) for generating accurate medical reports. Our approach incorporates prior knowledge from radiologists' Eye Gaze Region (EGR) to refine the fidelity and comprehensibility of report generation. Specifically, we design a Dual Fine-Grained Branch (DFGB) and a Multi-Task Branch (MTB) to collaboratively ensure the alignment of visual and textual semantics across multiple levels. To establish fine-grained alignment between EGR-related images and sentences, we introduce the Sentence Fine-grained Prototype Module (SFPM) within DFGB to capture cross-modal information at different levels. Additionally, to learn the alignment of EGR-related image topics, we introduce the Multi-task Feature Fusion Module (MFFM) within MTB to refine the encoder output information. Finally, a specifically designed label matching mechanism is designed to generate reports that are consistent with the anticipated disease states. The experimental outcomes indicate that the introduced methodology surpasses previous advanced techniques, yielding enhanced performance on two extensively used benchmark datasets: Open-i and MIMIC-CXR.

Sensitivity Decouple Learning for Image Compression Artifacts Reduction.

With the benefit of deep learning techniques, recent researches have made significant progress in image compression artifacts reduction. Despite their improved performances, prevailing methods only focus on learning a mapping from the compressed image to the original one but ignore the intrinsic attributes of the given compressed images, which greatly harms the performance of downstream parsing tasks. Different from these methods, we propose to decouple the intrinsic attributes into two complementary features for artifacts reduction, i.e., the compression-insensitive features to regularize the high-level semantic representations during training and the compression-sensitive features to be aware of the compression degree. To achieve this, we first employ adversarial training to regularize the compressed and original encoded features for retaining high-level semantics, and we then develop the compression quality-aware feature encoder for compression-sensitive features. Based on these dual complementary features, we propose a Dual Awareness Guidance Network (DAGN) to utilize these awareness features as transformation guidance during the decoding phase. In our proposed DAGN, we develop a cross-feature fusion module to maintain the consistency of compression-insensitive features by fusing compression-insensitive features into the artifacts reduction baseline. Our method achieves an average 2.06 dB PSNR gains on BSD500, outperforming state-of-the-art methods, and only requires 29.7 ms to process one image on BSD500. Besides, the experimental results on LIVE1 and LIU4K also demonstrate the efficiency, effectiveness, and superiority of the proposed method in terms of quantitative metrics, visual quality, and downstream machine vision tasks.

Dual modality prompt learning for visual question-grounded answering in robotic surgery.

With recent advancements in robotic surgery, notable strides have been made in visual question answering (VQA). Existing VQA systems typically generate textual answers to questions but fail to indicate the location of the relevant content within the image. This limitation restricts the interpretative capacity of the VQA models and their ability to explore specific image regions. To address this issue, this study proposes a grounded VQA model for robotic surgery, capable of localizing a specific region during answer prediction. Drawing inspiration from prompt learning in language models, a dual-modality prompt model was developed to enhance precise multimodal information interactions. Specifically, two complementary prompters were introduced to effectively integrate visual and textual prompts into the encoding process of the model. A visual complementary prompter merges visual prompt knowledge with visual information features to guide accurate localization. The textual complementary prompter aligns visual information with textual prompt knowledge and textual information, guiding textual information towards a more accurate inference of the answer. Additionally, a multiple iterative fusion strategy was adopted for comprehensive answer reasoning, to ensure high-quality generation of textual and grounded answers. The experimental results validate the effectiveness of the model, demonstrating its superiority over existing methods on the EndoVis-18 and EndoVis-17 datasets.

Fully Spiking Actor Network With Intralayer Connections for Reinforcement Learning.

With the help of special neuromorphic hardware, spiking neural networks (SNNs) are expected to realize artificial intelligence (AI) with less energy consumption. It provides a promising energy-efficient way for realistic control tasks by combining SNNs with deep reinforcement learning (DRL). In this article, we focus on the task where the agent needs to learn multidimensional deterministic policies to control, which is very common in real scenarios. Recently, the surrogate gradient method has been utilized for training multilayer SNNs, which allows SNNs to achieve comparable performance with the corresponding deep networks in this task. Most existing spike-based reinforcement learning (RL) methods take the firing rate as the output of SNNs, and convert it to represent continuous action space (i.e., the deterministic policy) through a fully connected (FC) layer. However, the decimal characteristic of the firing rate brings the floating-point matrix operations to the FC layer, making the whole SNN unable to deploy on the neuromorphic hardware directly. To develop a fully spiking actor network (SAN) without any floating-point matrix operations, we draw inspiration from the nonspiking interneurons found in insects and employ the membrane voltage of the nonspiking neurons to represent the action. Before the nonspiking neurons, multiple population neurons are introduced to decode different dimensions of actions. Since each population is used to decode a dimension of action, we argue that the neurons in each population should be connected in time domain and space domain. Hence, the intralayer connections are used in output populations to enhance the representation capacity. This mechanism exists extensively in animals and has been demonstrated effectively. Finally, we propose a fully SAN with intralayer connections (ILC-SAN). Extensive experimental results demonstrate that the proposed method outperforms the state-of-the-art performance on continuous control tasks from OpenAI gym. Moreover, we estimate the theoretical energy consumption when deploying ILC-SAN on neuromorphic chips to illustrate its high energy efficiency.

Cascaded Attention: Adaptive and Gated Graph Attention Network for Multiagent Reinforcement Learning.

Modeling the interactive relationships of agents is critical to improving the collaborative capability of a multiagent system. Some methods model these by predefined rules. However, due to the nonstationary problem, the interactive relationship changes over time and cannot be well captured by rules. Other methods adopt a simple mechanism such as an attention network to select the neighbors the current agent should collaborate with. However, in large-scale multiagent systems, collaborative relationships are too complicated to be described by a simple attention network. We propose an adaptive and gated graph attention network (AGGAT), which models the interactive relationships between agents in a cascaded manner. In the AGGAT, we first propose a graph-based hard attention network that roughly filters irrelevant agents. Then, normal soft attention is adopted to decide the importance of each neighbor. Finally, gated attention further refines the collaborative relationship of agents. By using cascaded attention, the collaborative relationship of agents is precisely learned in a coarse-to-fine style. Extensive experiments are conducted on a variety of cooperative tasks. The results indicate that our proposed method outperforms state-of-the-art baselines.

Adversarial Reciprocal Points Learning for Open Set Recognition.

Open set recognition (OSR), aiming to simultaneously classify the seen classes and identify the unseen classes as 'unknown', is essential for reliable machine learning. The key challenge of OSR is how to reduce the empirical classification risk on the labeled known data and the open space risk on the potential unknown data simultaneously. To handle the challenge, we formulate the open space risk problem from the perspective of multi-class integration, and model the unexploited extra-class space with a novel concept Reciprocal Point. Follow this, a novel learning framework, termed Adversarial Reciprocal Point Learning (ARPL), is proposed to minimize the overlap of known distribution and unknown distributions without loss of known classification accuracy. Specifically, each reciprocal point is learned by the extra-class space with the corresponding known category, and the confrontation among multiple known categories are employed to reduce the empirical classification risk. Then, an adversarial margin constraint is proposed to reduce the open space risk by limiting the latent open space constructed by reciprocal points. To further estimate the unknown distribution from open space, an instantiated adversarial enhancement method is designed to generate diverse and confusing training samples, based on the adversarial mechanism between the reciprocal points and known classes. This can effectively enhance the model distinguishability to the unknown classes. Extensive experimental results on various benchmark datasets indicate that the proposed method is significantly superior to other existing approaches and achieves state-of-the-art performance. The code is released on github.com/iCGY96/ARPL.

Joint Semantic and Latent Attribute Modelling for Cross-Class Transfer Learning.

A number of vision problems such as zero-shot learning and person re-identification can be considered as cross-class transfer learning problems. As mid-level semantic properties shared cross different object classes, attributes have been studied extensively for knowledge transfer across classes. Most previous attribute learning methods focus only on human-defined/nameable semantic attributes, whilst ignoring the fact there also exist undefined/latent shareable visual properties, or latent attributes. These latent attributes can be either discriminative or non-discriminative parts depending on whether they can contribute to an object recognition task. In this work, we argue that learning the latent attributes jointly with user-defined semantic attributes not only leads to better representation but also helps semantic attribute prediction. A novel dictionary learning model is proposed which decomposes the dictionary space into three parts corresponding to semantic, latent discriminative and latent background attributes respectively. Such a joint attribute learning model is then extended by following a multi-task transfer learning framework to address a more challenging unsupervised domain adaptation problem, where annotations are only available on an auxiliary dataset and the target dataset is completely unlabelled. Extensive experiments show that the proposed models, though being linear and thus extremely efficient to compute, produce state-of-the-art results on both zero-shot learning and person re-identification.