RESUMO
BACKGROUND: Aspirin resistance has been associated with an adverse long-term outcome in patients with atherosclerotic coronary artery disease, but more studies are needed. HYPOTHESIS: The aim of this study was to investigate the impact of aspirin resistance, assessed by the Platelet Function Analyzer-100 (PFA-100) (Dade Behring Inc., Deerfield, Ill., USA) on the long-term prognosis in patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS). METHODS: A total of 496 consecutive patients were studied. The 1-y incidence of cardiovascular death was the prespecified study endpoint. The patients were divided, according to the values of PFA-100 collagen epinephrine closure time (CEPI-CT) upon presentation, into aspirin sensitives (those with a PFA-100 CEPI-CT>193 sec) and aspirin resistants (those with a PFA-100 CEPI-CTAssuntos
Síndrome Coronariana Aguda/mortalidade
, Aspirina/uso terapêutico
, Resistência a Medicamentos
, Inibidores da Agregação Plaquetária/uso terapêutico
, Idoso
, Distribuição de Qui-Quadrado
, Determinação de Ponto Final
, Feminino
, Humanos
, Incidência
, Masculino
, Testes de Função Plaquetária
, Prognóstico
, Modelos de Riscos Proporcionais
, Fatores de Risco
, Estatísticas não Paramétricas