Efeito da administração oral de extrato etanólico de Rosmarinus officinalis L. (alecrim) no desenvolvimento do Tumor Sólido de Ehrlich / Effect of oral administration of the ethanol extract of Rosmarinus officinalis L. (alecrim) in the development of Ehrlich Solid Tumor

objetivo deste estudo foi avaliar os efeitos da administração oral diária de extrato etanólico de R.officinalis no desenvolvimento do Tumor Sólido de Ehrlich. Camundongos Swiss foram separados em três grupos A, B e C (n=6). Os animais do grupo A (controle) ingeriram solução salina durante todo o experimento. Os animais do grupo B, a partir do 1º dia, receberam diariamente, por gavagem, uma dose de 100 mg/kg do extrato etanólico de R.officinalis. Os animais do grupo C iniciaram, no 21º dia, a ingestão diária desse extrato. No 21º dia, todos os camundongos foram inoculados subcutaneamente no coxim plantar esquerdo com 2 x 106 células do Tumor de Ehrlich. No 42º dia, os animais foram sacrificados e suas patas foram removidas para análise histopatológica. Os resultados obtidos, através da mensuração da espessura das patas, mostraram que o grupo controle e os grupos que receberam o extrato, apresentaram o mesmo crescimento tumoral. Nas análises histopatológicas, não foram observadas diferenças na morfologia das células tumorais entre os grupos. A administração oral diária de 100 mg/kg de extrato etanólico de Rosmarinus officinalis não afetou o potencial proliferativo de tumor. Outras concentrações do extrato etanólico de Rosmarinus officinalis serão estudadas em experimentos futuros.(AU)

The aim of this study was to evaluate the effects of daily oral administration of ethanol extract of R.officinalis in the development of Ehrlich solid tumor. Swiss mice were divided into three groups A, B and C (n = 6). The animals of group A (control) received saline throughout the experiment. The animals of group B, from day 1, received daily by gavage, a dose of 100 mg/kg of R.officinalis ethanol extract. The animals of group C, on day 21, began the daily intake of this extract. At day 21, all mice were inoculated with 2 x 106 Ehrlich tumor cells in the left footpad. On day 42, the animals were sacrificed; their footpads were measured and removed for histopathological analysis. The results showed that the control group and the groups receiving the extract, before and after tumor inoculation, presented the same tumor growth. Furthermore, the histopathological analysis showed no differences in the morphology of tumor cells between groups. The daily oral administration of 100 mg/kg ethanol extract of Rosmarinus officinalis did not affect the proliferative potential of tumor. Other concentrations this ethanol extract times will be studied in future experiments.(AU)

Relationship between periodontal status and degree of visual impairment in institutionalized individuals.

OBJECTIVE: Periodontal disease is a set of inflammatory infections that affect the supporting structures of the dentition. Patients with visual impairment (VI) may have more difficulty in cleaning and maintaining oral health. The purpose of this study was to investigate the possible relationship between periodontal status and degree of VI in institutionalized individuals. MATERIALS AND METHODS: Fifty-two visually impaired individuals were included in this cross-sectional study. The periodontal parameters assessed were clinical attachment level (CAL), probing depth (PD), and visible plaque index. The degree of VI was established as: Group 1 (mild or moderate VI), Group 2 (severe or profound VI), and Group 3 (completely blind); and the types of VI were considered as congenital and acquired. Fisher's exact, Kruskal-Wallis, Mann-Whitney, and Spearman correlation coefficient test were used. The level of significance was set at 5%. RESULT: Only plaque index was higher on proximal surfaces of subjects with mild/moderate VI when compared to the other degrees of VI (P = 0.01). Furthermore, we observed higher values for interproximal CAL (P = 0.01), total PD (P = 0.04), and interproximal PD in subjects with acquired VI when compared to subjects with congenital VI (P = 0.01). CONCLUSIONS: These findings suggest that periodontal status may be more related to the type of disability than with the degree of VI. Acquired VI people presented a worse periodontal health than the group with congenital VI.