1.
Eur J Med Chem
; 44(10): 4004-9, 2009 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19500884
RESUMO
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates.
Assuntos
Hidrazonas/química , Hidrazonas/farmacologia , Tiofenos/química , Tiofenos/farmacologia , Vasodilatadores/química , Vasodilatadores/farmacologia , Animais , Aorta Torácica/efeitos dos fármacos , Cristalografia por Raios X , Hidrazonas/síntese química , Masculino , Modelos Moleculares , Ratos , Ratos Wistar , Tiofenos/síntese química , Vasodilatadores/síntese química
2.
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 2): o250, 2009 Jan 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21581866
RESUMO
In the title compound, C(17)H(14)O(3), the pyran ring adopts a boat conformation and the dihedral angle between the aromatic ring planes is 59.1â (1)°. In the crystal structure inter-molecular C-Hâ¯O hydrogen bonds and C-Hâ¯π inter-actions link the mol-ecules.
