[Cardiac syndrome in females with systemic undifferentiated dysplasia of the connective tissue]. / Sindrom porazheniia serdtsa u zhenshchin s sistemnoi nedifferentsirovannoi displaziei soedinitel'noi tkani.

The trial enrolled 119 women with systemic undifferentiated dysplasia of the connective tissue (DCT) aged 14-39 years; 86.6% of them had asthenic constitution. Ultrasound most frequently found prolapse of mitral cusps and accessory chord as in the left ventricle. Use of chest x-ray, echocardiography, ECG 24-h monitoring and transesophageal pacing discovered combination of heart dislocation, changed intracardiac structures, disturbed rhythm and conduction in 87 examinees. This provided the diagnosis of dysplastic heart syndrome. Multiple significant correlations between echocardiometric parameters, hormonal indices, neuroendocrine disorders, reproductive disorders point to close relations between cardiovascular and neuroendocrine systems in women with DCT.

[Neuroendocrine dysfunction in female patients with systemic dysplasia of the connective tissue]. / Neiroéndokrinnaia difunktsiia u zhenshchin s sistemnoi displaziei soedinitel'noi tkani.

The study covered 119 women with systemic undifferentiated dysplasia of the connective tissue (DCT) aged 14-39 years. All the examinees had vegetative disorders, 26.1% had a neuroendocrine-metabolic form of hypothalamic syndrome (HS), 51.3%--premenopausal syndrome, 65.5%--dysmenorrhea. It was found that women with DCT and HS develop symptoms of neuroendocrine disorders at earlier age than those with HS but free of DCT. Arterial hypertension was registered in 96.8% of patients with DCT and HS, 80.3% of DCT patients with premenopausal syndrome. Central hemodynamics was different in DCT patients without neuroendocrine disorders and with neuroendocrine dysfunction evidencing the role of the latter in development of arterial hypertension in DCT.