RESUMO
Ibopamine was administered in a dose of 100 mg every 8 hours for three days to 18 hospitalised heart patients of NYHA class I and II. ECHO examination, polygraphic examination, rheographic examination and carotid CW Doppler were carried out under basal conditions and at the end of treatment. B.P. did not show significant changes whereas H.R. showed a slight tendency to rise. PEPc fell significantly whereas LVETw did not change, with a parallel reduction in PEP/LVET. ECHO examination did not reveal any reduction in diameters, an increase in Vcfm and a reduction in Ses. The Ses/Vs and P/V contractility indices increased to some extent. Irrelevant changes were observed in peripheral circulation evaluated with rheography, and cerebral circulation evaluated with CW Doppler. On the basis of these results it can be concluded that ibopamine is in a position to determine an improvement in ventricular performance during heart failure and that, allowing for its sympathergic effects, it is the treatment of choice in bradykinetic decompensation.
Assuntos
Cardiotônicos/uso terapêutico , Desoxiepinefrina/análogos & derivados , Dopamina/análogos & derivados , Hemodinâmica/efeitos dos fármacos , Vasodilatadores/uso terapêutico , Cardiomiopatias/diagnóstico , Cardiomiopatias/tratamento farmacológico , Cardiomiopatias/fisiopatologia , Sistema Cardiovascular/efeitos dos fármacos , Sistema Cardiovascular/fisiopatologia , Desoxiepinefrina/uso terapêutico , Avaliação de Medicamentos , Ecocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de TempoAssuntos
Arteriopatias Oclusivas/tratamento farmacológico , Perna (Membro)/irrigação sanguínea , Pirrolidinas/uso terapêutico , Administração Oral , Adolescente , Adulto , Idoso , Ensaios Clínicos como Assunto , Avaliação de Medicamentos , Feminino , Humanos , Isquemia/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Pirrolidinas/administração & dosagem , Doença de Raynaud/tratamento farmacológicoRESUMO
Five years' experience at the coronary unit of the S. Angelo Hospital medical division is described. Practical considerations are offered with regard to the management of arrhythmia with drugs, electroconversion and electrostimulation.