1.
J Org Chem
; 69(8): 2881-3, 2004 Apr 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15074946
RESUMO
Starting from racemic 4-hydroxy-4-methyl-2-cyclopentenone, a family of enantiopure carbanucleosides locked in the northern conformation has been synthesized. The use of ionic liquids was determinant in the last step resulting in a tangible increase of the yields and dramatic reduction of reaction times and volumes of organic solvents. To our knowledge, this is the first example of the use of ionic liquids in the coupling of carbasugars with heterocyclic bases.