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1.
Int J Ment Health Addict ; 21(2): 711-728, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-34642579

RESUMO

The COVID-19 is a "unique" stressor, which can produce physical and psychological trauma. Coping styles can buffer this psychological impact. Consequently, this paper aims to psychometrically adapt the Fear of COVID-19 scale (FCV-19S) to Spanish and examines the relationships between FCV-19S, stress response, and coping strategies. The sample comprised a convenience sample of 1146 participants (12-83 years), 880 from Spain (76.8%), and 266 from Dominican Republic (23.2%). Overall, the findings support a one-factor structure for FCV-19S, consisting of 7-items, and was invariant across age, sex, occupational status, and cross-national. Therefore, indicating evidences of construct validity. Evidences of reliability were also observed (Cronbach's α = .86, McDonald's ω = .86, Guttmann's λ6 = .86, greatest lower bound = .91, composite reliability = .85, and average variance extracted = .44). Moreover, as regards criterion-related validity, the mediation analysis indicated that the relationship between FCV-19S and acute stress was positive and high, with maladaptive coping styles mediating the relationship, and with a stronger mediation for men. The findings give evidences of the reliability and validity of the Spanish version of FCV-19S among Spanish-speaker participants, which provides the chance of cross-cultural studies.

2.
Int J Ment Health Addict ; : 1, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34803548

RESUMO

[This corrects the article DOI: 10.1007/s11469-021-00615-x.].

3.
Ann Anat ; 229: 151456, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31911160

RESUMO

Nipples represent a highly specialized skin with capital importance in mammals for breastfeeding and additionally in humans due to sexuality. The histological studies regarding this region are scarce, so 42 human nipples were studied to describe the morphology of the nipple innervation. Our results exclude the presence of a rich innervation on nipple's skin or superficial dermis, thus definitely excluding nipple skin from the concept glabrous skin. The presence of mechanoreceptors is limited to scarce Merkel cells on the epidermis and some corpuscular capsulated and non-capsulated structures in the dermis; Merkel cells progressively decrease with ageing. No Meissner corpuscles were found and the rare Pacinian corpuscles identified were close to vascular structures and embroidered in the mammary fatty tissue. The great sensitivity observed functionally on the breast and especially in the nipple can be morphologically explained by two elements; on the one hand there is a rich smooth muscle innervation present in the deep dermis; on the other hand the mammary gland demonstrate Piezo2 expression in many glandular cells, with two differentiated patterns in the ductal and in the acinar tissue of the breast. The role of Piezo2 in the normal mammary gland is discussed.


Assuntos
Mamilos/inervação , Células Receptoras Sensoriais/fisiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Proteínas de Ligação ao Cálcio/análise , Criança , Feminino , Humanos , Imuno-Histoquímica , Canais Iônicos/metabolismo , Células de Merkel/ultraestrutura , Pessoa de Meia-Idade , Proteínas de Neoplasias/análise , Mamilos/anatomia & histologia , Corpúsculos de Pacini/anatomia & histologia , Glândulas Sebáceas/anatomia & histologia , Adulto Jovem
4.
RSC Adv ; 10(20): 11892-11897, 2020 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-35496611

RESUMO

The growth mechanism of layered α-MoO3 nano- and microplates on the surface of Mo wires during Joule heating has been investigated by application of an external electric field to the current carrying wire. The observed rapid growth of the structures, involving enhanced diffusion processes associated to the intense electric current, is further enhanced by the external field leading to a near instantaneous formation of MoO3 plates. Thermally assisted electromigration in the Mo wire with the additional effect of the electric field appears as a very time effective method to grow MoO3 layered low dimensional structures. Other molybdenum oxide nanostructures, such as nanospheres and nanocrystallites with different shapes, have been found to grow by deposition from the Mo wire on the electrodes used to apply the external electric field. The growth on the electrodes takes place by a thermally assisted electric-field-driven process.

5.
Ann Anat ; 224: 62-72, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31005573

RESUMO

Pacinian corpuscles are onion bulb-like multilayered mechanoreceptors that consist of a complicated structure of axon terminals, Schwann related cells (inner core), endoneural related cells (intermediate layer) and perineurial related cells (outer core-capsule). The cells forming those compartments are continuous and share the properties of that covering the nerve fibers. Small leucine-rich proteoglycans are major proteoglycans of the extracellular matrix and regulate collagen fibrillogenesis, cell signalling pathways and extracellular matrix assembly. Here we used immunohistochemistry to investigate the distribution of class I (biglycan, decorin, asporin, ECM2 and ECMX) and class II (fibromodulin, lumican, prolargin, keratocan and osteoadherin) small leucine-rich proteoglycans in human cutaneous Pacinian corpuscles. The distribution of these compounds was: the inner core express decorin, biglycan, lumican, fibromodulin, osteoadherin; the intermediate layer display immunoreactivity for osteoadherin; the outer core biglycan, decorin, lumican, fibromodulin and osteoadherin; and the capsule contains biglycan, decorin, fibromodulin, and lumican. Asporin, prolargin and keratocan were undetectable. These results complement our knowledge about the distribution of small leucine-rich proteoglycans in human Pacinian corpuscles, and help to understand the composition of the extracellular matrix in these sensory formations.


Assuntos
Corpúsculos de Pacini/química , Proteoglicanas/análise , Adolescente , Adulto , Animais , Antígenos CD34/análise , Biglicano/análise , Criança , Decorina/análise , Equidae , Proteínas da Matriz Extracelular/análise , Fibromodulina/análise , Dedos , Imunofluorescência , Cabras , Humanos , Imuno-Histoquímica , Camundongos , Pessoa de Meia-Idade , Proteoglicanas/classificação , Coelhos , Proteínas S100/análise , Pele/anatomia & histologia , Vimentina/análise , Adulto Jovem
6.
Acta Psychiatr Scand ; 140(1): 5-19, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-30980525

RESUMO

OBJECTIVE: To assess internalizing and externalizing symptoms as risk factors for suicidal behaviour and suicide among adolescents and young adults. METHOD: We conducted a systematic review of articles published until January 2017. We identified 26 883 potential papers; 1701 full-text articles were assessed for eligibility, of which 1479 were excluded because of methodological reasons. Diverse meta-analyses were performed for each group of symptoms. Odds ratios (ORs) and 95% confidence intervals (95% CI) or beta coefficients for categorical variables, and effect size (ES) were calculated for continuous variables. RESULTS: Finally, 41 studies were included, involving participants aged 12-26 years for a systematic review, and 24 articles were included for meta-analysis. The meta-analysis showed that youths with any internalizing (ES = 0.93) or externalizing symptoms (ES = 0.76 and OR = 2.59) were more likely to attempt suicide in future. This effect was also seen in depression symptoms (OR = 6.58 and ES = 1.00), legal problems (OR = 3.36), and anxiety (ES = 0.65). CONCLUSION: Reported internalizing and externalizing symptoms are predictors of suicide behaviour in young people; therefore, the detection and management of these symptoms in young populations could be a crucial strategy for preventing suicidality in this group.


Assuntos
Sintomas Comportamentais , Suicídio , Adolescente , Adulto , Sintomas Comportamentais/epidemiologia , Criança , Humanos , Estudos Longitudinais , Fatores de Risco , Suicídio/estatística & dados numéricos , Adulto Jovem
7.
Ann Anat ; 219: 8-24, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29842990

RESUMO

Meissner's and Pacinian corpuscles are cutaneous mechanoreceptors responsible for different modalities of touch. The development of these sensory formations in humans is poorly known, especially regarding the acquisition of the typical immunohistochemical profile related to their full functional maturity. Here we used a panel of antibodies (to specifically label the main corpuscular components: axon, Schwann-related cells and endoneurial-perineurial-related cells) to investigate the development of digital Meissner's and Pacinian corpuscles in a representative sample covering from 11 weeks of estimated gestational age (wega) to adulthood. Development of Pacinian corpuscles starts at 13 wega, and it is completed at 4 months of life, although their basic structure and immunohistochemical characteristics are reached at 36 wega. During development, around the axon, a complex network of S100 positive Schwann-related processes is progressively compacted to form the inner core, while the surrounding mesenchyme is organized and forms the outer core and the capsule. Meissner's corpuscles start to develop at 22 wega and complete their typical morphology and immunohistochemical profile at 8 months of life. In developing Meissner's corpuscles, the axons establish complex relationships with the epidermis and are progressively covered by Schwann-like cells until they complete the mature arrangement late in postnatal life. The present results demonstrate an asynchronous development of the Meissner's and Pacini's corpuscles and show that there is not a total correlation between morphological and immunohistochemical maturation. The correlation of the present results with touch-induced cortical activity in developing humans is discussed.


Assuntos
Dedos/anatomia & histologia , Mecanorreceptores/fisiologia , Corpúsculos de Pacini/crescimento & desenvolvimento , Adolescente , Adulto , Idoso , Animais , Anticorpos/imunologia , Axônios/fisiologia , Colágeno Tipo IV/análise , Feminino , Dedos/embriologia , Imunofluorescência , Idade Gestacional , Humanos , Imuno-Histoquímica , Lactente , Recém-Nascido , Masculino , Mecanorreceptores/citologia , Camundongos , Pessoa de Meia-Idade , Corpúsculos de Pacini/embriologia , Gravidez , Coelhos , Pele/anatomia & histologia , Pele/embriologia , Pele/crescimento & desenvolvimento
8.
Nanotechnology ; 29(3): 035401, 2018 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-29176063

RESUMO

In this paper, we present a study of silicon surface passivation based on the use of spin-coated hybrid composite layers. We investigate both undoped poly(3,4-ethylenedioxythiophene)/poly-(styrenesulfonate) (PEDOT:PSS), as well as PEDOT:PSS functionalized with semiconducting oxide nanomaterials (TiO2 and SnO2). The hybrid compound was deposited at room temperature by spin coating-a potentially lower cost, lower processing time and higher throughput alternative compared with the commonly used vacuum-based techniques. Photoluminescence imaging was used to characterize the electronic properties of the Si/PEDOT:PSS interface. Good surface passivation was achieved by PEDOT:PSS functionalized by semiconducting oxides. We show that control of the concentration of semiconducting oxide nanoparticles in the polymer is crucial in determining the passivation performance. A charge carrier lifetime of about 275 µs has been achieved when using SnO2 nanoparticles at a concentration of 0.5 wt.% as a filler in the composite film. X-ray diffraction (XRD), scanning electron microscopy, high resolution transmission electron microscopy (HRTEM), energy dispersive x-ray in an SEM, and µ-Raman spectroscopy have been used for the morphological, chemical and structural characterization. Finally, a simple model of a photovoltaic device based on PEDOT:PSS functionalized with semiconducting oxide nanoparticles has been fabricated and electrically characterized.

9.
J Appl Microbiol ; 124(4): 958-964, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28649706

RESUMO

AIM: To improve the efficacy of intercalating dyes to distinguishing between infectious and inactivated hepatitis A virus (HAV) in food. METHODS AND RESULTS: Different intercalating dyes were evaluated for the discrimination between infectious and thermally inactivated HAV suspensions combining with the RT-qPCR proposed in the ISO 15216. Among them, PMAxx was the best dye in removing the RT-qPCR signal from inactivated HAV. Applied to lettuce and spinach, PMAxx-Triton pretreatment resulted in complete removal of the RT-qPCR signal from inactivated HAV. Likewise, this study demonstrates that this pretreatment is suitable for the discrimination of inactivated HAV in shellfish without further sample dilution. In mussels and oysters, the developed viability RT-qPCR method reduced the signal of inactivated HAV between 1·7 and 2·2 logs at high inoculation level, and signal was completely removed at low inoculation level. CONCLUSIONS: This study showed that the use of PMAxx is an important improvement to assess HAV infectivity by RT-qPCR. It was shown that PMAxx-Triton pretreatment is suitable for the analysis of infectious HAV in complex food samples such as vegetables and shellfish. SIGNIFICANCE AND IMPACT OF THE STUDY: The PMAxx-Triton pretreatment can be easily incorporated to the ISO norm for infectious virus detection.


Assuntos
Vírus da Hepatite A/isolamento & purificação , Reação em Cadeia da Polimerase em Tempo Real/métodos , Frutos do Mar/virologia , Verduras/virologia , Águas Residuárias/virologia , Animais , Bivalves/virologia , Microbiologia de Alimentos , Vírus da Hepatite A/classificação , Vírus da Hepatite A/genética , Lactuca/virologia , Ostreidae/virologia , RNA Viral/genética , Esgotos/virologia , Spinacia oleracea/virologia
10.
J Autism Dev Disord ; 48(1): 198-208, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-28932960

RESUMO

Restricted and repetitive behavior (RRB) is one of the two key diagnostic features of autism spectrum disorder (ASD). DSM-5 highlights the importance of severity-based diagnostic modifiers assigned on the basis of intensity of needed supports. Therefore, there is a need for available measures that assess the severity of RRB. The repetitive behavior scale-revised (RBS-R) is probably the most used informant-based rating scale for the assessment of RRB and interests observed in ASD. The present study examined the psychometric properties of the Spanish version of the RBS-R in a sample of 233 participants with ASD, aged 3 to 63 years. Results revealed a six-factor model, good internal consistency, and concurrent-divergent validity. These findings suggest the utility of the Spanish version of RBS-R.


Assuntos
Transtorno do Espectro Autista/diagnóstico , Transtorno do Espectro Autista/psicologia , Transtornos Traumáticos Cumulativos/diagnóstico , Transtornos Traumáticos Cumulativos/psicologia , Inquéritos e Questionários/normas , Adolescente , Adulto , Transtorno do Espectro Autista/epidemiologia , Criança , Pré-Escolar , Transtornos Traumáticos Cumulativos/epidemiologia , Manual Diagnóstico e Estatístico de Transtornos Mentais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Psicometria , Espanha/epidemiologia , Adulto Jovem
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