Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Ceratose/induzido quimicamente , Ceratose/fisiopatologia , Líquen Plano/induzido quimicamente , Líquen Plano/fisiopatologia , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Idoso , Ciclofosfamida/efeitos adversos , Doxorrubicina/efeitos adversos , Humanos , Masculino , Prednisona/efeitos adversos , Rituximab/efeitos adversos , Resultado do Tratamento , Vincristina/efeitos adversosAssuntos
Melanoma/cirurgia , Neoplasias Cutâneas/cirurgia , Pele/patologia , Biópsia/efeitos adversos , Biópsia/métodos , Humanos , Margens de Excisão , Melanoma/diagnóstico , Melanoma/patologia , Estadiamento de Neoplasias , Estudos Retrospectivos , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologiaRESUMO
BACKGROUND: The therapeutic value of ultraviolet A1 (UVA1) phototherapy has been acknowledged for many years. Initially developed predominately for experimental and diagnostic purposes, it was subsequently recognised as a beneficial therapeutic modality in atopic dermatitis and localised scleroderma, and more recently a variety of sclerosing and fibrosing dermatoses, T-lymphocyte mediated disorders, both inflammatory and infiltrative, and several predominately dermal processes previously unresponsive to current therapies. METHODS: We present a retrospective evaluation of outcomes and treatment tolerability in adult patients using a low dose (30 joules/cm2 ), regimen administered in our private dermatologic practice, between 2006 and December 2019. RESULTS: Major clinical groups represented include atopic dermatitis, localised and systemic sclerodermas, mycosis fungoides, urticarial dermatitis, generalised pruritus and granuloma annulare. Eighty-seven patients are included in this study with 92% of all patients experiencing a beneficial result, 54% having complete and 38% partial relief of presenting signs and/or symptoms. UVA1 therapy was well tolerated, with no patients ceasing treatment due to adverse effects. CONCLUSIONS: Ultraviolet A1 is an effective and safe treatment option in many hitherto recalcitrant cutaneous conditions.
Assuntos
Dermatopatias/radioterapia , Terapia Ultravioleta , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto JovemRESUMO
BACKGROUND: Common foot and toenail problems may cause diagnostic and management difficulties and are often complicated by comorbid factors. OBJECTIVE: The aim of this article is to discuss common disorders of the skin and nails of the feet, regional physiological factors to consider and appropriate investigations and management. DISCUSSION: Cutaneous disorders of the feet and nails present significant diagnostic and management challenges given the considerable overlap of common signs and symptoms and regionally difficult management.
