Relationship between natural muscle oscillation frequency and lower limb muscle performance during instrumented sit-to-stand and stand-to-sit movements on a novel device in sedentary subjects.

BACKGROUND: Despite the significance of muscle oscillation frequency, previous research has not established a correlation with muscle performance due to the challenges of applying resistance without altering natural motion during functional tests. RESEARCH QUESTION: What is the correlation between muscle oscillation frequency and lower limb muscle strength, power, and work during an instrumented sit-to-stand and stand-to- sit (iSTS-TS) task among sedentary subjects? METHODS: In a cross-sectional study, the oscillation frequency of the gastrocnemius medialis (GM), biceps femoralis (BF), and vastus medialis (VM) muscles in both the dominant (D) and non-dominant (ND) legs was assessed with a handheld myotonometer in 34 sedentary individuals before performing the iSTS-TS task. RESULTS: In the isokinetic mode, no significant correlations were found. In the isotonic mode, the BF muscle oscillation frequency in the D and ND legs exhibited significant positive correlations with peak force, peak power, and work during sitting down, as well as peak power and work during standing up. Positive correlations were observed in both legs between the GM oscillation frequency and sitting down peak force and work. Additionally, significant positive correlation was found with standing up work in the D leg. Muscle oscillation frequency of the VM exhibited a positive correlation with sitting down peak force in the ND leg. SIGNIFICANCE: Due to a greater number of correlations found, it is advisable to use the isotonic mode when assessing muscle oscillation frequency in relation to muscle performance during functional iSTS-TS tasks in sedentary subjects.

Androgen and Estrogen ß Receptor Expression Enhances Efficacy of Antihormonal Treatments in Triple-Negative Breast Cancer Cell Lines.

The triple-negative breast cancer (TNBC) subtype is characterized by the lack of expression of ERα (estrogen receptor α), PR (progesterone receptor) and no overexpression of HER-2. However, TNBC can express the androgen receptor (AR) or estrogen receptor ß (ERß). Also, TNBC secretes steroid hormones and is influenced by hormonal fluctuations, so the steroid inhibition could exert a beneficial effect in TNBC treatment. The aim of this study was to evaluate the effect of dutasteride, anastrozole and ASP9521 in in vitro processes using human TNBC cell lines. For this, immunofluorescence, sensitivity, proliferation and wound healing assays were performed, and hormone concentrations were studied. Results revealed that all TNBC cell lines expressed AR and ERß; the ones that expressed them most intensely were more sensitive to antihormonal treatments. All treatments reduced cell viability, highlighting MDA-MB-453 and SUM-159. Indeed, a decrease in androgen levels was observed in these cell lines, which could relate to a reduction in cell viability. In addition, MCF-7 and SUM-159 increased cell migration under treatments, increasing estrogen levels, which could favor cell migration. Thus, antihormonal treatments could be beneficial for TNBC therapies. This study clarifies the importance of steroid hormones in AR and ERß-positive cell lines of TNBC.

Comparative evaluation of the dentoalveolar effects of three Class II correctors: A finite element analysis study.

OBJECTIVE: To compare the stress distribution and total strain applied to the dentition, periodontal ligament (PDL) and cortical and trabecular bones by three Class II correctors using finite element analysis. DESIGN: Three-dimensional analysis of stresses and total strain of the dentition with three Class II correctors. SETTING: Computational study. METHODS: Three-dimensional finite element models of Class II elastics, the Forsus Fatigue Resistant Device (FRD) and the Carriere Motion Appliance (CMA) were constructed from a cone-beam computed tomography (CBTC) image of an orthodontic Class II patient. The distribution of stress (von Mises and principal stress) and the total strain (mm) in maxillo-mandibular dentition, PDL, cortical and trabecular bone were analysed. RESULTS: The highest von Mises yield and the maximum principal stress in the three models were found at the teeth, followed by the cortical bone, trabecular bone and PDL. The maximum stress and total deformation were located at the upper canines and lower molars in the Class II elastics and CMA models, in the upper first molars in the Forsus FRD and CMA, and in the lower first premolars in the Forsus FRD. In addition, stress was distributed in the anterior and posterior regions of the teeth, and the total deformation was found in the distal direction in the upper arch and in the mesial direction in the lower arch. CONCLUSION: The stress concentrations in the three models were located close to the active components of each appliance, producing specific patterns of stress distribution and displacement that should be taken into account when planning the type of appliance to be used for the correction of the Class II malocclusion.

Sound-encoded faces activate the left fusiform face area in the early blind.

Face perception in humans and nonhuman primates is accomplished by a patchwork of specialized cortical regions. How these regions develop has remained controversial. In sighted individuals, facial information is primarily conveyed via the visual modality. Early blind individuals, on the other hand, can recognize shapes using auditory and tactile cues. Here we demonstrate that such individuals can learn to distinguish faces from houses and other shapes by using a sensory substitution device (SSD) presenting schematic faces as sound-encoded stimuli in the auditory modality. Using functional MRI, we then asked whether a face-selective brain region like the fusiform face area (FFA) shows selectivity for faces in the same subjects, and indeed, we found evidence for preferential activation of the left FFA by sound-encoded faces. These results imply that FFA development does not depend on experience with visual faces per se but may instead depend on exposure to the geometry of facial configurations.

Prevalencia de la exóstosis del conducto auditivo externo entre practicantes de surf y bodyboard en la costa central de Chile / Prevalence of auditory canal exostosis among surfers and bodyboarding athletes of the central Chilean coast

La exóstosis del conducto auditivo externo (ECAE), también conocida como oído de surfista, es una alteración del tejido óseo del oído externo, principalmente causada debido a la sobrexposición al frío. Considerando que los practicantes de deportes acuáticos como el surf y bodyboard de las costas del pacífico sur se exponen a aguas con temperaturas entre 12-16 °C, se busca determinar, en este estudio, la prevalencia y grado de ECAE en practicantes de surf y bodyboard de las localidades de Reñaca y Concón durante el año 2018. Se realizó una evaluación del CAE mediante video-otoscopía a 67 personas (134 oídos) practicantes de surf y bodyboard de las playas de Reñaca y Concón, y se les aplicó un cuestionario respecto a sus hábitos de práctica. Como resultado, se observó una prevalencia de ECAE del 77,6%, siendo el 61,2% ECAE bilateral y el 16,4% ECAE unilateral. Se pudo determinar, además, que el 62,3%de los participantes no usa protecciones. A partir de estos hallazgos, es posible concluir que existe una alta prevalencia de la ECAE en practicantes de surf y bodyboard en las costas centrales chilenas, lo que debería alertar tanto a la población practicante como a profesionales de la salud auditiva con el fin de promover una vida saludable en esta población.

External auditory canal exostosis (ECAE), also known as surfer's ear, is an alteration of the bone tissue of the external ear, mainly caused due to overexposure to cold. Considering that those who practice water sports such as surfing and bodyboarding on the Pacific coast are exposed to waters with temperatures between 12-16 °C,. We seek to determine, in this study, the prevalence and degree of ECAE in surfers and bodyboarders from the coast of the south of Pacific Ocean, Reñaca and Concón, during the year 2018. An evaluation of the ECAE was carried out by means of video-otoscopy in 67 people (134 ears) who practiced surfing and bodyboarding from the beaches of Reñaca and Concón, and a questionnaire was used to collect information about their practice habits. As a result, a prevalence of ECAE of 77.6% was observed, with 61.2% bilateral ECAE and 16.4% unilateral ECAE. It was also possible to determine that 62.3% of the participants do not use protections. Based on these findings, it is possible to conclude that there is a high prevalence of ECAE in surfers and bodyboarders on the central Chilean coasts, which should alert both the practicing population and hearing health professionals to promote a healthy life in this population.

Can urine studies be replaced by serum free light chains measurements to assign responses in multiple myeloma patients?

Serum and urine protein electrophoresis and immunofixation are the preferred techniques for monitoring monoclonal proteins and evaluating treatment response in multiple myeloma (MM) patients with measurable disease. However, urine studies are subjected to limitations that may lead to inaccuracies or prevent guidelines compliance. We retrospectively studied if the substitution of urine studies by measuring serum free light chains (sFLCs) results in a comparable disease monitoring, both in intact immunoglobulin (II) and light chain (LC) MM patients. In our cohort, equal or higher percentages of disease were identified by sFLCs at baseline and maximum response as compared to urine studies. Achieving very good partial response or better (≥VGPR) according to the response criteria proposed by the French group (evaluating sFLCs instead of urine) and the IMWG response criteria were associated to a 62% and 63% reduced risk of progression, respectively. A similar prognostic value for reaching ≥VGPR was also observed among LCMM patients when the French group and the IMWG response criteria were applied. Overall, these results support the replacement of urine studies by the sFLCs assay in IIMM. In LCMM, sFLCs could be used for monitoring and urine studies could be performed only to confirm complete remissions and progressions.

Pensamiento y aprendizaje en animales y humanos: los excluidos / Thinking and learning in animals and humans: the excluded / Pensament I aprenentatge en animals I humans: els exclosos

En el presente artículo, reflexionamos sobre la exclusión de otras especies, así como de grupos humanos, a los que se les somete y se les violenta, a partir de coloquios después del visionado de vídeos y películas. Partimos de la hipótesis de que cuando se adornan ciertos grupos humanos de narcisismo patológico, estos se convierten en supremacistas, o en mentes que funcionan predominantemente en la parte psicótica de la personalidad. Hay una represión de las representaciones más ori­ginales que dificultan la comprensión, la empatía, el trabajo y el vínculo social

In this article, we reflect on the exclusion of other species, as well as of human groups, to which they are subjected and which are subjected to violence, based on discussions after watching videos and films. We start from the hypothesis that when certain human groups are embellished with pathological narcissism, they become supremacists, or minds that function predominantly in the psychotic part of the personality. There is a repression of the most original representations that make un­derstanding, empathy, work and social bonding difficult

En el present article, reflexionem sobre l'exclusió d'altres espècies, així com de grups humans, als quals se'ls sotmet I se'ls violenta, a partir de col·loquis després del visionament de vídeos I pel·lícules. Partim de la hipòtesi que quan es revesteixen certs grups humans de narcisisme patològic, aquests es converteixen en supremacistes, o en ments que funcionen predominantment en la part psicòtica de la personalitat. Hi ha una repressió de les representacions més originals que dificulten la comprensió, l'empatia, el treball I el vincle social

Unexpected population fragmentation in an endangered seabird: the case of the Peruvian diving-petrel.

In less than one century, the once-abundant Peruvian diving petrel has become the first endangered seabird of the Humboldt Current System (HCS). This small endemic petrel of the South American Pacific coast is now an important indicator of ongoing habitat loss and of the success of local conservation policies in the HCS - an ecoregion designated as a priority for the conservation of global biodiversity. Yet so far, poorly understood life history traits such as philopatry or dispersal ability may strongly influence the species' response to ecosystem changes, but also our capacity to assess and interpret this response. To address this question, we explore the range-wide population structure of the Peruvian diving petrel, and show that this small seabird exhibits extreme philopatric behavior at the island level. Mitochondrial DNA sequences and genome-wide SNP data reveal significant isolation and low migration at very short distances, and provide strong evidence for questioning the alleged recovery in the Peruvian and Chilean populations of this species. Importantly, the full demographic independence between colonies makes local population rescue through migration unlikely. As a consequence, the Peruvian diving petrel appears to be particularly vulnerable to ongoing anthropogenic pressure. By excluding immigration as a major factor of demographic recovery, our results highlight the unambiguously positive impact of local conservation measures on breeding populations; yet at the same time they also cast doubt on alleged range-wide positive population trends. Overall, the protection of independent breeding colonies, and not only of the species as a whole, remains a major element in the conservation strategy for endemic seabirds. Finally, we underline the importance of considering the philopatric behavior and demographic independence of breeding populations, even at very fine spatial scales, in spatial planning for marine coastal areas.

Morphological characteristics of Street Workout practitioners.

INTRODUCTION: The determination of the morphological characteristics of the most popular sports has allowed the evaluation and comparison between athletes, which has helped to improve their performance. The Street Workout is an emerging sport based on calisthenics, which recently has become popular. Despite its popularization, neither the morphologic profile nor the morphologic characteristics of Street Workout athletes has been determined. OBJECTIVE: Determine the profile and morphological characteristics of Street-Workout athletes, through anthropometry. MATERIAL AND METHODS: Fourteen athletes (22.7 ± 3.26 years) were recruited from the National Calisthenics Tournament 2015 in Chile. The athletes were evaluated following the protocol of the International Society for the Advancement of Kinanthropometry to determine the somatotype, body composition, as well as indices of body composition such as body mass index, waist to hip ratio, waist to height ratio, fat/muscle mass and muscle/bone mass indexes. RESULTS: Street Workout practitioners presented a balanced-mesomorphic somatotype, a low fat mass and a high muscular development, with upper arms and trunk predominance. Regarding body composition indices, the values obtained allow us to classify them as a low-risk population of chronic non-communicable diseases. CONCLUSION: The present study sets a first antecedent of the morphological characteristics of Street Workout, determining that the Street Workout athletes presented balanced-mesomorphic somatotype and were classified as a healthy and athletic sample by their body composition indexes.

Morphological characteristics of Street Workout practitioners / Características morfológicas de practicantes de Street Workout

Introduction: The determination of the morphological characteristics of the most popular sports has allowed the evaluation and comparison between athletes, which has helped to improve their performance. The Street Workout is an emerging sport based on calisthenics, which recently has become popular. Despite its popularization, neither the morphologic profile nor the morphologic characteristics of Street Workout athletes has been determined. Objective: Determine the profile and morphological characteristics of Street-Workout athletes, through anthropometry. Material and methods: Fourteen athletes (22.7 ± 3.26 years) were recruited from the National Calisthenics Tournament 2015 in Chile. The athletes were evaluated following the protocol of the International Society for the Advancement of Kinanthropometry to determine the somatotype, body composition, as well as indices of body composition such as body mass index, waist to hip ratio, waist to height ratio, fat/muscle mass and muscle/bone mass indexes. Results: Street Workout practitioners presented a balanced-mesomorphic somatotype, a low fat mass and a high muscular development, with upper arms and trunk predominance. Regarding body composition indices, the values obtained allow us to classify them as a low-risk population of chronic non-communicable diseases. Conclusion: The present study sets a first antecedent of the morphological characteristics of Street Workout, determining that the Street Workout athletes presented balanced-mesomorphic somatotype and were classified as a healthy and athletic sample by their body composition indexes (AU)

Introducción: la determinación de las características morfológicas de los deportes más populares ha permitido la evaluación y comparación entre los atletas, lo que ha contribuido a mejorar su rendimiento. El street workout (ejercicio callejero) es un deporte emergente basado en ejercicios de calistenia, el cual ha ido ganando popularidad en los últimos años. A pesar de su masificación, aún no ha sido determinado el perfil morfológico ni las características morfológicas de los atletas de street workout. Objetivo: determinar las características y el perfil morfológico de los atletas de street workout mediante antropometría. Material y métodos: catorce atletas (22,7 ± 3,26 años de edad promedio) fueron reclutados del Torneo Nacional de Calistenia del año 2015 en Chile. Los atletas fueron evaluados siguiendo el protocolo de la Sociedad Internacional para el Avance de la Kineantropometría para determinar el somatotipo, la composición corporal, así como también índices de composición corporal tales como el índice de masa corporal, cintura/cadera, cintura/talla masa grasa/músculo y músculo/masa ósea. Resultados: los atletas de street workout evaluados presentaron un somatotipo mesomórfico balanceado, una baja masa grasa y un alto desarrollo muscular, con dominancia en miembros superiores y tronco. Respecto a los índices de composición corporal, los valores obtenidos permiten clasificar a este grupo de atletas como una población de bajo riesgo de enfermedades crónicas no transmisibles. Conclusión: el presente estudio sienta el primer antecedente de las características morfológicas del street workout, estableciendo que los atletas evaluados presentan un somatotipo mesomórfico equilibrado, siendo clasificados como una muestra atlética y saludable por sus índices de composición corporal (AU)

Elección del modelo de proporcionalidad antropométrica en una población deportista; comparación de tres métodos / Anthropometric proportionality method election in a sport population; comparison of three methods

Introducción: la aplicación de modelos de proporcionalidad, basados en proporciones ideales, tendría un gran impacto en el deporte de alto rendimiento, debido a que los mejores deportistas tienden a asemejarse antropométricamente. Objetivo: el objetivo de este estudio es comparar los métodos de proporcionalidad antropométrica: Phantom, Combinado y Escalable, en los campeones chilenos de fútbol masculino universitario de los años 2012 y 2013, ocupando como población de criterio a futbolistas profesionales sudamericanos, con el fin de encontrar el método de proporcionalidad más adecuado para poblaciones de deportistas. Metodología: se realizó la evaluación de 22 variables kineantropométricas, según el protocolo ISAK, a una muestra constituida por 13 jugadores pertenecientes a la selección masculina de fútbol de la Pontificia Universidad Católica de Valparaíso. Se obtuvieron los valores Z de cada variable antropométrica de los diferentes métodos, usando sus fórmulas respectivas. Se usó como población de criterio a los futbolistas profesionales sudamericanos. Resultados: se observó una tendencia semejante entre los tres métodos. Se encontraron diferencias significativas (p < 0,05) en los valores Z de los métodos Escalable y Combinado, respecto al método Phantom. No se encontraron diferencias significativas entre los resultados obtenidos por los métodos Combinado y Escalable, excepto en los perímetros radiocarpiano, cadera y muslo. Conclusión: se propone la utilización del método Escalable sobre el método Combinado y Phantom para realizar la comparación de valores Z en variables kineantropométricas en deportistas de la misma disciplina (AU)

Introduction: the proportionality model application, based on ideal proportions, would have a great impact on high performance sports, due to best athletes to resemble anthropometrically. Objective: the objective of this study was to compare the following anthropometric methods of proportionality: Phantom, Combined and Scalable, in male champion university Chilean soccer players in 2012 and 2013, using South American professional soccer players as criterion, in order to find the most appropriate proportionality method to sports populations. Method: the measerement of 22 kinanthropometric variables was performed, according to the ISAK protocol, to a sample constituted of 13 members of the men’s soccer team of the Pontificia Universidad Católica de Valparaíso. The Z-values of the anthropometrics variables of each method were obtained using their respective equations. It was used as criterion population South American soccer players. Results: a similar trend was observed between the three methods. Significant differences (p <0.05) were found in some Z-values of Scalable and Combined methods compared to Phantom method. No significant differences were observed between the results obtained by the Combined and Scalable methods, except in wrist, thigh and hip perimeters. Conclusion: it is more appropriate to use the Scalable method over the Combined and Phantom methods for the comparison of Z values in kinanthropometric variables in athletes of the same discipline (AU)

Somatotipo y composición corporal de la selección de fútbol masculino universitario de Chile, Pontificia Universidad Católica de Valparaíso, campeona los años 2012 y 2013 / Somatotype and body composition of the male university soccer team at Pontificia Universidad Católica de Valparaíso, champions 2012-2013

El objetivo del presente estudio es determinar el somatotipo y la composición corporal de la selección masculina de fútbol universitario bicampeona del año 2013 y realizar la comparación de éstos entre posiciones de juego y con otras poblaciones de futbolistas. Se realizó una evaluación kineantropométrica a trece jugadores de la selección masculina de fútbol de la Pontificia Universidad Católica de Valparaíso (PUCV) 2013, utilizando el perfil completo del protocolo de la Sociedad Internacional para el Avance de la Kineantropometría (ISAK). Las mediciones se realizaron en pretemporada. Se determinó que el somatotipo de la selección masculina de fútbol de la PUCV 2013 corresponde a Endo-Mesomorfo (3,5­5,6­1,7). Los valores de composición corporal promedio de la selección de fútbol PUCV fueron 25,81% de masa grasa, 47,41% de masa muscular, 10,68% de masa ósea, 5,07% de masa piel y 11,03% de masa residual. No se encontraron diferencias significativas en los resultados expuestos en las diferentes posiciones en el campo de juego, con respecto a somatotipo, composición corporal y variables kineantropométricas analizadas (valor p >0,05). El perfil somatotípico de la selección masculina de fútbol de la PUCV 2013 es Endo-Mesomorfo, resultado similar al encontrado en otro estudio realizado en futbolistas universitarios. En cuanto a la composición corporal se observó que los porcentajes de tejido muscular y óseo se encuentran dentro de los rangos aceptables, mientras que el tejido graso se encuentra elevado respecto a otras poblaciones de futbolistas profesionales y universitarios.

The objective of this study was to determine the somatotype and body composition of the male university soccer team at Pontificia Universidad Católica de Valparaíso (PUCV) and then compare them, according to playing positions and other soccer populations. Thirteen players of the university soccer team at PUCV underwent a kineanthropometric evaluation, using the full profile of the International Society for the Advancement of Kinanthropometry (ISAK) protocol. The measures were performed in the 2013 pre-season. The somatotype of the male soccer team at PUCV corresponds to endomorphic-mesomorph (3.5­5.6­1.7). The average values of the body composition of the soccer team were 25.81% of fat mass, 47.41% of muscle mass, 10.68% of bone mass, 5.07% of skin mass and 11.03% of residual mass. No significant differences were observed among different playing positions with respect to the somatotype, for either body composition or any kineanthropometric variables analyze (p value >0.05). The somatotypical profile of the male university soccer team at PUCV is endo-mesomorphic, which is in accordance to a similar study conducted on university soccer players in Mexico. According to body composition, it was observed that the percentages of muscle and bone mass are in the acceptable ranges, while fat mass is elevated compared to other professional populations as well as other university soccer players.

[ANTHROPOMETRIC PROPORTIONALITY METHOD ELECTION IN A SPORT POPULATION; COMPARISON OF THREE METHODS]. / ELECCIÓN DEL MODELO DE PROPORCIONALIDAD ANTROPOMÉTRICA EN UNA POBLACIÓN DEPORTISTA; COMPARACIÓN DE TRES MÉTODOS.

INTRODUCTION: the proportionality model application, based on ideal proportions, would have a great impact on high performance sports, due to best athletes to resemble anthropometrically. OBJECTIVE: the objective of this study was to compare the following anthropometric methods of proportionality: Phantom, Combined and Scalable, in male champion university Chilean soccer players in 2012 and 2013, using South American professional soccer players as criterion, in order to find the most appropriate proportionality method to sports populations. METHOD: the measerement of 22 kinanthropometric variables was performed, according to the ISAK protocol, to a sample constituted of 13 members of the men's soccer team of the Pontificia Universidad Católica de Valparaíso. The Z-values of the anthropometrics variables of each method were obtained using their respective equations. It was used as criterion population South American soccer players. RESULTS: a similar trend was observed between the three methods. Significant differences (p < 0.05) were found in some Z-values of Scalable and Combined methods compared to Phantom method. No significant differences were observed between the results obtained by the Combined and Scalable methods, except in wrist, thigh and hip perimeters. CONCLUSION: it is more appropriate to use the Scalable method over the Combined and Phantom methods for the comparison of Z values in kinanthropometric variables in athletes of the same discipline.

Introducción: la aplicación de modelos de proporcionalidad, basados en proporciones ideales, tendría un gran impacto en el deporte de alto rendimiento, debido a que los mejores deportistas tienden a asemejarse antropométricamente. Objetivo: el objetivo de este estudio es comparar los métodos de proporcionalidad antropométrica: Phantom, Combinado y Escalable, en los campeones chilenos de fútbol masculino universitario de los años 2012 y 2013, ocupando como población de criterio a futbolistas profesionales sudamericanos, con el fin de encontrar el método de proporcionalidad más adecuado para poblaciones de deportistas. Metodología: se realizó la evaluación de 22 variables kineantropométricas, según el protocolo ISAK, a una muestra constituida por 13 jugadores pertenecientes a la selección masculina de fútbol de la Pontificia Universidad Católica de Valparaíso. Se obtuvieron los valores Z de cada variable antropométrica de los diferentes métodos, usando sus fórmulas respectivas. Se usó como población de criterio a los futbolistas profesionales sudamericanos. Resultados: se observó una tendencia semejante entre los tres métodos. Se encontraron diferencias significativas (p < 0,05) en los valores Z de los métodos Escalable y Combinado, respecto al método Phantom. No se encontraron diferencias significativas entre los resultados obtenidos por los métodos Combinado y Escalable, excepto en los perímetros radiocarpiano, cadera y muslo. Conclusión: se propone la utilización del método Escalable sobre el método Combinado y Phantom para realizar la comparación de valores Z en variables kineantropométricas en deportistas de la misma disciplina.

Right occipital cortex activation correlates with superior odor processing performance in the early blind.

Using functional magnetic resonance imaging (fMRI) in ten early blind humans, we found robust occipital activation during two odor-processing tasks (discrimination or categorization of fruit and flower odors), as well as during control auditory-verbal conditions (discrimination or categorization of fruit and flower names). We also found evidence for reorganization and specialization of the ventral part of the occipital cortex, with dissociation according to stimulus modality: the right fusiform gyrus was most activated during olfactory conditions while part of the left ventral lateral occipital complex showed a preference for auditory-verbal processing. Only little occipital activation was found in sighted subjects, but the same right-olfactory/left-auditory-verbal hemispheric lateralization was found overall in their brain. This difference between the groups was mirrored by superior performance of the blind in various odor-processing tasks. Moreover, the level of right fusiform gyrus activation during the olfactory conditions was highly correlated with individual scores in a variety of odor recognition tests, indicating that the additional occipital activation may play a functional role in odor processing.

Development of a fully automated system for delivering odors in an MRI environment.

We describe the development and evaluation of a computer-controlled system for delivering odors in a magnetic resonance imaging (MRI) environment. The system allows a timely presentation of different odors in synchrony with MRI sequences and participant's inspiration phase. The rise/fall time of odor deliverance has been optimized to generate prompt and strong stimulations. Equipped with a user-friendly programming interface, the system can be used reliably in a wide range of experimental paradigms. We have paid particular attention to developing a portable system that is relatively easy, rapid, and inexpensive to replicate. The equipment has been tested in a 3-Tesla MRI in a boxcar paradigm, in which stimulation conditions alternated with rest periods (no stimulation). The experiment demonstrated the good functioning of the device and its efficiency in producing the expected activation in the olfactory cortex; it also revealed some methodological and technical aspects to be improved.

Odour discrimination and identification are improved in early blindness.

Previous studies showed that early blind humans develop superior abilities in the use of their remaining senses, hypothetically due to a functional reorganization of the deprived visual brain areas. While auditory and tactile functions have been investigated for long, little is known about the effects of early visual deprivation on olfactory processing. However, blind humans make an extensive use of olfactory information in their daily life. Here we investigated olfactory discrimination and identification abilities in early blind subjects and age-matched sighted controls. Three levels of cuing were used in the identification task, i.e., free-identification (no cue), categorization (semantic cues) and multiple choice (semantic and phonological cues). Early blind subjects significantly outperformed the controls in odour discrimination, free-identification and categorization. In addition, the larger group difference was observed in the free-identification as compared to the categorization and the multiple choice conditions. This indicated that a better access to the semantic information from odour perception accounted for part of the improved olfactory performances in odour identification in the blind. We concluded that early blind subjects have both improved perceptual abilities and a better access to the information stored in semantic memory than sighted subjects.