Review of imaging techniques in the diagnosis of hepatocellular carcinoma in patients who require a liver transplant.

OBJECTIVES: The aim of the study was to retrospectively compare the diagnostic performance of ultrasound (US), contrast-enhanced multidetector computed tomography (MDCT) and contrast-enhanced MRI in cirrhotic patients who were candidates for liver transplantation. MATERIALS AND METHODS: A total of 273 consecutive patients with 218 hepatocellular carcinoma (HCC) nodules, who underwent imaging and subsequent transplantation, were examined. Diagnosis of HCC was based on explant correlation of the whole liver. Three different imaging data sets were evaluated: US, MDCT and MRI unenhanced and dynamic phases. Diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value, with corresponding 95% confidence intervals, were determined. Statistical analysis was performed for all lesions and for two lesion subgroups (≤2 and >2 cm). Preoperative tumour staging was analysed. RESULTS: Patient sensitivity to US, MDCT and MRI was 80.4, 81.1 and 90.5%, respectively. Specificity was 96.3, 96.2 and 82.1%. Combined US and MDCT improved sensitivity (88%) without significant loss in specificity (95.7%). Imaging tests resulted in accurate tumour staging in 83.4% of the patients. In per-nodule analysis, technique sensitivity was 55.6, 52.4 and 65.9%, respectively. Sensitivity figures improved when the nodule was larger than 2 cm. CONCLUSION: Combining imaging techniques is a good strategy for pretransplant HCC diagnosis and provides more accurate cancer staging in patients, which is necessary to decide the correct therapeutic approach.

Biopsia mamaria asistida por vacío y guiada por estereotaxia. Correlación con la biopsia quirúrgica / Stereotactic vacuum-assisted breast biopsy. Correlation with surgical excisional biopsy

Objetivo. Valorar la eficacia de la biopsia percutánea asistida por vacío y guiada por estereotaxia como alternativa a la biopsia quirúrgica diagnóstica. Material y métodos. Estudio retrospectivo de 250 biopsias asistidas por vacío guiadas por estereotaxia realizadas entre marzo del 2006 y agosto del 2010. Se ha analizado la tasa de falsos negativos y la subestimación diagnóstica en relación con la biopsia quirúrgica. Resultados. La tasa de falsos negativos fue del 2% (1/63) y el valor predictivo positivo fue del 100%. La biopsia quirúrgica evidenció hallazgos de carcinoma en el 30% (3/10) de los casos diagnosticados como hiperplasia ductal atípica y en el 33,3% (2/6) de los carcinomas lobulillares in situ. De las 40 lesiones diagnosticadas como carcinoma ductal in situ, la biopsia quirúrgica evidenció carcinomas infiltrantes en 4 de los casos (10%). Conclusiones. La biopsia guiada por estereotaxia puede considerarse una alternativa válida a la biopsia quirúrgica diagnóstica, aunque persiste la posibilidad de subestimación diagnóstica (AU)

Objective. To evaluate the efficiency of stereotactic vacuum-assisted core breast biopsy as an alternative to diagnostic surgical biopsy. Material and methods. A retrospective study based on 250 stereotactic vacuum-assisted percutaneous biopsies was conducted from March 2006 to August 2010. The false-negative rate and underestimation of disease at percutaneous biopsy were determined in comparison with diagnostic surgical biopsy. Results. The false-negative rate was 2% (1/63) and the positive predictive value was 100%. Surgical excision revealed carcinoma in 30% (3/10) of the patients with atypical ductal hyperplasia at core biopsy and in 33.3% (2/6) of those with lobular carcinoma in situ. Among 40 lesions diagnosed as ductal carcinoma in situ at vacuum-assisted biopsy, surgery revealed invasive carcinoma in four (10%). Conclusions. Stereotactic core breast biopsy can be considered a valid alternative to diagnostic surgical biopsy, although diagnostic underestimation still occurs (AU)

Indicación y utilidad de la ecografía urgente en la sospecha de apendicitis aguda / Indication and usefulness of ultrasonography for suspected acute appendicitis at the emergency department

Objetivo: La apendicitis aguda es la patología quirúrgica aguda abdominal más frecuente. Su diagnóstico constituye uno de los problemas más habituales en los servicios de urgencias. El objetivo del presente estudio es evaluar la utilidad de la ecografía abdominal en el diagnóstico de esta entidad. Material y método: Estudio retrospectivo realizado entre enero y junio del 2004 de todas las consultas realizadas en el servicio de urgencias por dolor abdominal indicativo de probable abdomen agudo, en los que se realizó una ecografía abdominal para descartar apendicitis aguda. Resultados: Se realizaron 2.015 ecografías abdominales urgentes de las cuales 296 fueron solicitadas para descartar el diagnóstico de apendicitis aguda, de éstas 288 fueron valorables. En 52 pacientes la ecografía fue indicativa de apendicitis aguda. En 15 casos el diagnóstico ecográfico fue discordante con el diagnóstico final. En 6 pacientes el informe ecográfico de apendicitis no se confirmó a posteriori. En 9 casos la ecografía fue no diagnóstica pese al diagnóstico quirúrgico de apendicitis aguda. Con estos datos, el rendimiento global de la ecografía para el diagnóstico de apendicitis aguda, se tradujo en una sensibilidad del 83,7%, especificidad del 97,4%, valor predictivo positivo del87,7%, valor predictivo negativo del 96,2%.Conclusiones: El rendimiento global de la ecografía abdominal en el diagnóstico de apendicitis aguda en nuestro medio es aceptable. Debido a su accesibilidad y bajo costees la prueba idónea para el diagnóstico en urgencias, sobre todo en casos dudosos (AU)

Objective: The aim of the present study was to assess the usefulness of ultrasonography in the diagnosis of acute appendicitis. Material and methods: Retrospective study which included patients presented in the emergency department with abdominal pain of suspected acute abdominal disorder origin and remitted to undergone ultrasonography to rule out appendicitis from January to July 2004.Results: Among 2015 ultrasonography scans 296 were performed to exclude a diagnosis of acute appendicitis. 288could be interpreted and the diagnosis of acute appendicitis was established in 52. In 15 cases the ultrasonography and the definite diagnosis differed. Ultrasonography and surgical diagnosis were different in 6 patients. In 9 patients the ultrasonography was not diagnostic. Ultrasound sensitivity, specificity, positive predictive value, and negative predictive value were 83,7%, 97,4%, 87,7% and 96,2%, respectively. Conclusions: The global cost-effectiveness of ultrasonography to diagnose appendicitis is good. Due to its availability and its low cost, ultrasonography is an accurate test for the diagnosis of acute appendicitis in emergency departments, specially in uncertain cases (AU)