RESUMO
Kingella kingae infections have aroused great interest in the last few years because of the increasing number of identified cases. Although considered an emerging pathogen, the increase in diagnosis of these infections can probably be explained by better knowledge of the bacteria, improved microbiological diagnostic techniques and greater awareness among clinicians. K. kingae is an aerobic cocobacillus with high tropism for osteoarticular tissue, endocardium, and vascular space. This pathogen mainly produces osteomyelitis, endocarditis, septic arthritis and bacteriemias. First choice antibiotics are penicillins and cephalosporins. This article reviews the literature on this microorganism.
Assuntos
Kingella kingae , Infecções por Neisseriaceae , Humanos , Infecções por Neisseriaceae/diagnóstico , Infecções por Neisseriaceae/terapiaRESUMO
Las infecciones por Kingella kingae han despertado recientemente un importante interés debido al mayor número de casos identificados. Aunque se considera un patógeno emergente, probablemente el mejor conocimiento de la bacteria, las mejores técnicas para el diagnóstico microbiológico y una mayor concienciación de los clínicos frente a este microorganismo justifican este aumento de casos descritos. K. kingae es un cocobacilo aerobio gramnegativo que presenta especial tropismo por el tejido osteoarticular, endocardio y espacio vascular. Las infecciones descritas con mayor frecuencia son osteomielitis, artritis séptica, endocarditis y bacteriemia. Los antimicrobianos de elección son penicilinas y cefalosporinas. Se revisa en este artículo la bibliografía relacionada con este microorganismo (AU)
Kingella kingae infections have aroused great interest in the last few years because of the increasing number of identified cases. Although considered an emerging pathogen, the increase in diagnosis of these infections can probably be explained by better knowledge of the bacteria, improved microbiological diagnostic techniques and greater awareness among clinicians. K. kingae is an aerobic cocobacillus with high tropism for osteoarticular tissue, endocardium, and vascular space. This pathogen mainly produces osteomyelitis, endocarditis, septic arthritis and bacteriemias. First choice antibiotics are penicillins and cephalosporins. This article reviews the literature on this microorganism (AU)
Assuntos
Humanos , Kingella kingae/isolamento & purificação , Infecções por Neisseriaceae/epidemiologia , Osteomielite/microbiologia , Artropatias/microbiologia , Endocardite Bacteriana/microbiologiaRESUMO
Fosamprenavir (FPV) efficacy in human immunodeficiency virus (HIV)-infected pediatric patients is still being evaluated in ongoing clinical trials. The long-term efficacy and safety of FPV boosted with ritonavir (FPV/r) was evaluated in 20 antiretroviral-naive and antiretroviral-experienced HIV-vertically infected pediatric patients. Analyses of CD4(+) T-cells, HIV-ribonucleic acid (RNA), and clinical status were performed during a median of 180 weeks. Initially, median HIV-RNA was 4.6 log(10) in naive and 4.4 log(10) in pretreated patients. Median CD4(+) T-cell was 17% and 31%, respectively. After FPV/r treatment, 18 of 20 patients achieved undetectable HIV-RNA and 4 of 20 experienced adverse events. To date, FPV/r treatment has shown sustained antiviral response and immunologic improvement in our 20 patients.
