RESUMO
AIM: The aim of this study was to determine the diagnostic capabilities of tumor markers in pleural effusion and their importance for assessment of the etiology of pleural effusions. PATIENTS AND METHODS: In pleural effusions from 166 patients hospitalized during the period 2003-2005 at the Department of Oncology and Radiotherapy, Faculty Hospital in Pilsen, the following tumor markers were determined: thymidine kinase (TK), neuron-specific enolase (NSE), cytokeratins [tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS) and cytokeratin fragment 19 (CYFRA 21-1)], carcinoembryonic antigen (CEA) and mucinous markers (CA 15-3, CA 19-9, CA 125). The inflammatory marker procalcitonin-PCT was also assessed. RESULTS: Tumor markers CA 125, TPA, TPS were significantly elevated in exudates, irrespective of the etiology, as a non-specific reaction in mesothelial cells. TK had a sensitivity of over 80% for all the types of cancer examined, while CA 15-3 had a sensitivity of over 90%. CONCLUSION: Significant positivity of PCT and CA 15-3 in pleural effusions indicate a suspicion of inflammatory disease. Positivity of TK and CA 15-3 indicate a strong suspicion of malignant exudates.
Assuntos
Biomarcadores Tumorais/análise , Neoplasias/diagnóstico , Derrame Pleural/química , Derrame Pleural/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Antígenos de Neoplasias/análise , Antígeno Ca-125/análise , Antígeno CA-19-9/análise , Calcitonina/análise , Peptídeo Relacionado com Gene de Calcitonina , Antígeno Carcinoembrionário/análise , Feminino , Humanos , Queratina-19 , Queratinas/análise , Masculino , Pessoa de Meia-Idade , Mucina-1/análise , Peptídeos/análise , Fosfopiruvato Hidratase/análise , Precursores de Proteínas/análise , Sensibilidade e Especificidade , Timidina Quinase/análise , Antígeno Polipeptídico Tecidual/análiseRESUMO
In the group of 450 patients operated in the Cardiosurgical Department of the Faculty Hospital in Plzen during the period from III/2003 till XI/2003, 1451 samples were collected to examine the following-procalcitonin levels (PCT), white blood cell counts (Leu) and C-reactive protein levels (CRP). The findings were assessed with respect to the respective patient's clinical status, and any correlation between procedures with extracorporeal circulation (MO), signs of inflammation, septic and non-septic serious complications and between the above mentioned markers levels, was searched. It was detected, that the PCT levels correlated well with the clinical signs of inflammation and sepsis, as well as with the non-inflammatory complications. The CRP and Leu changes were not statistically significant and their levels are commonly increased by the surgical procedure itself.
Assuntos
Calcitonina/sangue , Procedimentos Cirúrgicos Cardiovasculares , Complicações Pós-Operatórias/diagnóstico , Precursores de Proteínas/sangue , Biomarcadores/sangue , Proteína C-Reativa/análise , Peptídeo Relacionado com Gene de Calcitonina , Humanos , Contagem de LeucócitosRESUMO
In Plzen (Czechoslovakia) and Moscow (USSR), major lipid and apolipoprotein levels were studied in male industrial workers aged 20-60 and in men examined for the presence of ischaemic heart disease. Apolipoprotein B level and the B/B-I apolipoprotein ratio were found most suitable of all biochemical tests to distinguish patients with IHD from healthy people.
