RESUMO
We studied the effect of pectin gel particles on endotoxemia in mice induced by restraint stress. It was shown that the concentration of LPS in mouse blood increased during restraint stress, which was associated with memory impairment. Pectin gel particles prevented the development of stress-induced endotoxemia and memory impairment in mice.
Assuntos
Endotoxemia/metabolismo , Pectinas/química , Animais , Antioxidantes/metabolismo , Catalase/sangue , Catalase/metabolismo , Endotoxemia/tratamento farmacológico , Masculino , Malondialdeído/sangue , Malondialdeído/metabolismo , Camundongos , Ratos Wistar , Estresse Fisiológico/efeitos dos fármacos , Superóxido Dismutase/sangue , Superóxido Dismutase/metabolismo , Transaminases/sangue , Transaminases/metabolismoRESUMO
The aim of this study was to evaluate the effects of chronotype and social jetlag (SJL) on intelligence. Subjects were aged 14-25 years (n = 1008). A significant effect of intelligence on academic performance, as measured by the Raven's Standard Progressive Matrices test, was found (F2,917 = 11.75, P < 0.0001, η2 = 0.03). When SJL was less than 2 hours, the intelligence of people with late chronotype was found to be higher than that of subjects with early and intermediate chronotypes (F2,305 = 3.12, P < 0.05, η2 = 0.02). A negative effect of SJL on the results of intelligence testing was noted only in subjects with late chronotype (F2,536 = 2.61, P < 0.05, η2 = 0.02). Our data suggest that people with late chronotype have a higher level of intelligence, but these advantages disappear when SJL ≥2 hours.