[Characteristics of psychopathological symptomatology in HIV-infection schizophrenic patients]. / Nekotorye osobennosti psikhopatologicheskoi simptomatiki u bol'nykh shizofreniei s VICh-infektsiei.

AIM: To study the psychopathological structure of psychotic syndromes in HIV-infected schizophrenic patients and in patients without HIV infection. MATERIAL AND METHODS: Forty HIV-infected patients, 23 women and 17 men, with confirmed diagnosis of schizophrenia were included in the study. The control group consisted of 40 patients without HIV infection, 23 women (48%) and 17 men (52%). The psychopathological state in all patients was assessed with the PANSS. Flow cytometry was used to measure immunological parameters in HIV-infected patients. Data analysis included principal component analysis. RESULTS AND CONCLUSION: There were independent positive, negative and affective symptoms in the structure of syndromes of schizophrenic patients without HIV. The structure of syndromes in HIV-infected schizophrenic patients included cognitive deficit as well.

[Prediction of the changes of immunological status and psychopathological data in HIV-infected schizophrenia patients].

AIM: To predict the immunological status in HIV-infected patients with schizophrenia based on a set of clinical and psychopathological characteristics of the endogenous process. MATERIAL AND METHODS: The study included 28 patients with confirmed diagnosis of schizophrenia and HIV status. Authors used psychopathological method, along with psychometric scales (PANSS), in patients with schizophrenia and an immunological method for the determination of HIV-associated status and viral load. RESULTS: Affective syndromes with severe depressive symptoms, volitional impairment, high impulsivity and social features of autism can be prognostically favorable factors for the immune status of HIV-infected patients with schizophrenia that obviously indicates an acute psychotic state. Negative (deficit) symptoms were prognostically unfavorable for the immune status of HIV-infected patients with schizophrenia and for psychosis course. CONCLUSION: Favorable immune status corresponds to acute psychosis whereas the forms with severe deficit are associated with immunosuppression in HIV-infected patients.