[Effect of 6-month S-methylmethionine intake on the quality of life and dyspepsia symptoms in patients with chronic gastritis].

S-methylmethionine (methylmethionine sulfonium chloride), better known as vitamin U, is a metabolic substrate that affects many metabolic processes in the human organism. Since its discovery, a large number of studies has been produced demonstrating its safety and effectiveness in various diseases, especially in diseases of the gastrointestinal tract. The purpose of the study was to evaluate the effect of methylmethionine sulfonium chloride (vitamin U) intake on the symptoms of dyspepsia and the quality of life of patients with chronic gastritis. Material and methods. The study included 37 patients (21 men and 16 women) aged 35-60 years with chronic gastritis of various etiologies. After inclusion in the study, all patients were prescribed S-methylmethionine at a dose of 300 mg per day. Clinical manifestations of dyspepsia were assessed using the GSRS questionnaire (Gastrointestinal Symptom Rating Scale), quality of life was assessed using the SF 36 questionnaire. The survey was conducted before the start of the therapy, after 3 and 6 months of complex diet therapy. Results. The most pronounced manifestations were dyspeptic (from 3 to 9 points) and diarrheal syndromes (from 2 to 5 points). Other indicators of the GSRS scale did not exceed 4 points. The total score was 15 points. By the 3rd month of therapy, there was a statistically significant decrease in the total score to 9 points (p<0.05). By the 6th month of therapy, the total GSRS score averaged 5.5 points (p<0.05). According to the SF 36 questionnaire, by the end of the 3rd month of therapy, indicators such as PF - physical functioning, BP - Bodily pain and SF - social functioning improved. By the end of the 6th month of therapy, several other indicators also improved (RP - role-physical functioning, GH - general perception of health, VT - viability, RE - Role-Emotional; MH - mental health) (p<0.05). Conclusion. The study showed that the appointment of dietary supplements containing methylmethionine sulfonium chloride at a dose of 300 mg per day helps to reduce the severity of dyspeptic symptoms in patients with chronic gastritis and their quality of life.

[Electroacupuncture in the prevention of the immunosuppressive action of surgical stress]. / Elektroakupunkturnaia profilaktika immunosupressivnogo deistviia operationnogo stressa.

Immunological indexes have been studied in 22 patients during planned herniotomy and in 52 healthy donors. The study group comprised 12 patients operated on under local anesthesia in combination with electroacupuncture analgesia (EAPA). Premedication was not performed, narcotic analgesics, neuroleptics and antihistamine agents were also excluded. The control group consisted of 10 patients operated on under local anesthesia after premedication with promedol. Analgesia in the postoperative period was performed using chEHC-2 apparatus in the study group and using narcotic analgesics in the control group. Most indexes characterizing the initial immune status were decreased in both groups, as compared to those observed in healthy donors. A pronounced immunomodulating effect of EAPA on immunoregulatory subpopulations of T-lymphocyte helpers/inducers (Tmu) and suppressors/killers (T gamma) was noted. EAPA did not affect optimal relations between immunoregulatory subpopulations, which was confirmed by immunoregulatory index value, and prevented inhibition of functional lymphocyte activity in blasttransformation reaction to mitogen (PHA).