1.
Bioorg Med Chem Lett
; 12(4): 689-92, 2002 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11844702
RESUMO
Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38MAPK. The most active isomers were those possessing an aryl group alpha and a heteroaryl group beta relative to the nitrogen atom in the 2-position of the central pyridazine. Additionally, substitution in the 6-position of the central pyridazine with a variety of dialkylamino substituents afforded a set of inhibitors having good (p38 IC50 1-20 nM) in vitro activity.