Insulated Offloading Provides Offloading Protection and Enhanced Skin Perfusion.

INTRODUCTION: Locally and neurally mediated vasodilation of the cutaneous vasculature has been shown to occur in response to locally and systemically applied heat stresses. The resultant shunting of blood to the periphery can be upwards of 7 L/min to 8 L/min when profound heat stresses are applied. The increased cutaneous circulation from local heat stress may benefit extremities afflicted with a wound or area of compromised arterial supply. Insulating the extremity also may increase local cutaneous perfusion. OBJECTIVE: This study aims to determine if increased local warmth from an insulated offloading boot or mitt (designed to protect an extremity from trauma, offload the extremity to prevent pressure ulcers, and insulate the extremity to minimize heat loss) also results in increased local cutaneous perfusion using indocyanine green fluorescence angiography (ICGFA). MATERIALS AND METHODS: Nine patients from an outpatient wound care clinic with a wound or area of compromised arterial supply on the upper or lower extremity were studied prior to and following a minimum of a single 60-minute session of insulated offloading boot or mitt use utilizing ICGFA. Measurements taken were time to first onset of fluorescence (seconds) and ingress and egress rates for the area of concern and the remainder of the area imaged. RESULTS: All 9 patients exhibited signs of increased local warmth by a mean of 3.1ºF while body temperature decreased by a mean of 1.2ºF. Local cutaneous perfusion increased with a mean change of 1 for the ingress rate to the area of concern and a mean change of 0.1 to the remainder of the area imaged. Also, ICGFA was able to demonstrate preferential shunting of the increased cutaneous perfusion to the site of most need. CONCLUSIONS: These findings suggest enhanced skin perfusion may be an additional advantage of insulated offloading boot or mitt use.

Treatment of Nonreconstructable Critical Limb Ischemia With Ischemic Wounds Utilizing a Noninvasive Intermittent Pneumatic Compression Device Monitored With Fluorescence Angiography.

INTRODUCTION: Critical limb ischemia (CLI) is a leading cause of lower extremity amputation. When CLI is identified, revascularization should be performed if possible. When options for revascularization do not exist, use of a noninvasive intermittent pneumatic compression device (NPCD) can be considered. OBJECTIVE: Presented here are 2 cases of patients with nonreconstructable CLI at risk for limb loss who were serially assessed with indocyanine green fluorescence angiography (ICGFA) to determine the effects of NPCD use on local tissue perfusion. MATERIALS AND METHODS: Both patients were treated with the NPCD for 1 hour, 3 times per day, for 4 weeks. Serial ICGFA utilizing a ICGFA device was performed at various time points to monitor the effects of NPCD use on tissue perfusion. RESULTS: The treatment of both patients with serial ICGFA provided limited objective evidence of increased local tissue perfusion which expedited wound resolution. CONCLUSIONS: Larger randomized control trials of this modality of perfusion assessment and NPCD use are recommended.

Charcot Foot: Clinical Clues, Diagnostic Strategies, and Treatment Principles.

Acute Charcot neuroarthropathy of the foot and ankle is often difficult to diagnose because of limited findings in the patient history, physical examination, imaging, and laboratory studies. Delay in treatment results in the development of rigid foot and ankle deformities, increasing the risk of ulceration, infection, and major lower extremity amputation. Acute Charcot neuroarthropathy should be suspected in any patient 40 years or older with obesity and peripheral neuropathy who presents with an acutely swollen foot following minimal or no recalled trauma and who reports minimal to no pain, particularly if radiography and laboratory markers of infection are normal. Magnetic resonance imaging or computed tomography should be performed in these cases. If changes consistent with acute Charcot neuroarthropathy are observed, prompt immobilization and/or referral to a foot and ankle subspecialist is needed to minimize sequelae. Immobilization should continue until lower extremity edema and warmth resolve, and serial radiography shows evidence of osseous consolidation. Intranasal calcitonin salmon may have a role as adjunctive therapy. Although controversial, surgery may be indicated if there is severe dislocation or instability, concern for skin breakdown, or failure of conservative treatment to obtain a stable, plantigrade foot.

Current concepts in pain management: pharmacologic options for the pediatric, geriatric, hepatic and renal failure patient.

This article provides a review for current practice. Strict guidelines are not available on some topics, and they may never be drafted because pain is such a unique individual experience. It is recommended to coordinate care with other medical specialties when patients present with organ dysfunctions or are at the extremes of age. More data are required in the field of pain management, particularly with regard to renal and hepatic dysfunction. In turn, these data serve as a foundation for physicians making practice decisions based on current evidence. Until this is achieved, clinicians must rely on anecdotal evidence and the experiences of others to treat a complex issue: pain.

Topical misoprostol and wound healing in rats.

UNLABELLED: Background. It is well known that prostaglandins play an integral part in wound healing, yet there is scant evidence to support the use of exogenous topical prostaglandins as potential wound healing agents. This study on rats begins that exploration by studying the effects of topical misoprostol on acute wound healing. METHODS: Twenty-six rats had 2-cm x 2-cm full-thickness wounds created on their dorsal surface: one-half had topical misoprostol powder mixed with saline applied daily for 3 weeks, while the other half had only normal saline applied. Photos to measure wound size were taken every 3 days to document any changes. RESULTS: Statistical analysis revealed that topical misoprostol can lead to decreased healing times. CONCLUSION: Topical misoprostol powder can decrease the healing time of acute wounds in rats. Further studies are needed to confirm this finding, as well as to explore its use in chronic wounds.