[The induction and elimination of cytogenetic disorders in monkey lymphocytes following thiophosphamide action]. / Induktsiia i éliminatsiia tsitogeneticheskikh narushenii v limfotsitakh obez'ian posle vozdeistviia tiofosfamidom.

The dynamics of sister chromatid exchanges and chromosome aberrations in lymphocyte of monkey has been investigated after a thiophosphamide exposure. The process of induction and elimination of cytogenetic damages was described by the mathematical model. Developing the model in detail will allow to make a cytogenetic prognosis of remote consequences of mutagenic exposure.

[Quantitative comparison of the cytogenetic effect of thiophosphamide during in vivo and in vitro action on monkey lymphocytes]. / Kolichestvennoe sravnenie tsitogeneticheskogo éffekta tiofosfamida pri deistvii na limfotsity obez'ian in vivo i in vitro.

Mutagenic in vivo and in vitro effects were compared quantitatively by the investigation of sister chromatid exchange (SCE) rate and chromosomal aberrations caused by thiophosphamide in macaca rhesus lymphocytes. The integral of thiophosphamide concentration in the blood or culture fluid by a certain time period was used for the estimation of the dose of mutagenic exposure. It was shown that the dose-response relationships and corresponding regression coefficients were similar when the in vivo and in vitro results were compared. The data obtained indicate the possibility for quantitative extrapolation of the results obtained in vitro on the entire organism.

[Incidence of chromosome aberrations in the bone marrow of monkeys and their progeny after exposure to aflatoxin B1]. / Chastota aberratsii khromosom v kostnom mozge obez'ian i ikh potomstva posle vozdeistviia aflatoksinom B1.

A mutagenic effect of aflatoxin B1 (AFB1) was studied in somatic cells of primates. It is shown that AFB1 elevates the chromosome aberration frequency in bone marrow cells of two monkey species: Macaca mulatta and Papio hamadryas. Genome mutations were found in these experimental primates simultaneously with chromosome aberrations. The AFB1-induced chromosome aberrations were revealed at least during two years of the study. The fact of the chromosome aberration frequency increase was established in Macaca babies born from females who received AFB1 in pregnancy.

Frequency of chromosome aberrations in bone marrow of monkeys and their F1 after aflatoxin B1 injection.

A mutagenic effect of aflatoxin B1 (AFB1) in somatic cells of primates is investigated. It is shown that AFB1 elevated the frequency of chromosome aberrations in the bone marrow of two species of monkeys: Macaca mulatta and Papio hamadryas. Beside chromosome aberrations, genome mutations were found in these experimental primates. AFB1-induced chromosome aberrations were constantly revealed during two years of study. Increase in the frequency of chromosome aberrations could be demonstrated in Macaca babies born from females that had received AFB1 at the final stage of pregnancy.