RESUMO
Ability of actin to polymerise and depolymerise makes it essential to key functions of eukaryotic cell. The functioning of actin is controlled by a host of regulatory proteins, the repertoire of which in diatoms is known to remarkably differ from other organisms. We have performed a phylogenetic analysis of 521 actin and actin-related proteins' aminoacid sequences, as well as 190 sequences of gelsolin family proteins from various genomic and transcriptomic datasets. Based on the results of this analysis, as well as on the presence of clade-specific indels in some of the actin-related proteins, we describe a novel ARP subfamily, dubbed ARP12, which is specific to heterokonts and related organisms. We also describe two novel diatom-specific subfamilies, dGRC1 and dGRC2, among short gelsolin repeat-containing proteins.
Assuntos
Actinas/genética , Diatomáceas/genética , Gelsolina/genética , Actinas/química , Actinas/metabolismo , Proteínas de Algas/química , Proteínas de Algas/genética , Proteínas de Algas/metabolismo , Sequência de Aminoácidos , Proteínas de Ligação ao Cálcio , Gelsolina/química , Gelsolina/metabolismo , Família Multigênica , Proteínas de Protozoários , Alinhamento de SequênciaRESUMO
The development of pentylenetetrazole-induced kindling is accompanied by neurodegeneration and neuronal loss in different areas of the hippocampus. However, the data on neurodegeneration development in the dentate gyrus remain controversial. In our study that was performed on 20 Wistar male rats, it was found that the process of neuronal loss was expressed unequally along the dentate gyrus. By the end of pentylenetetrazole kindling development, degenerating cells were present in the superior and inferior blades of the dentate gyrus, whereas the neuronal density in these areas was not reduced. On the other hand, in the angle of the dentate gyrus neuronal loss was already detected at the very early stages of kindling development. These findings allow to suggest a functional heterogeneity of a population of granule cells in relation to their susceptibility to seizure-induced injury.
Assuntos
Convulsivantes/efeitos adversos , Giro Denteado/patologia , Excitação Neurológica/efeitos dos fármacos , Doenças Neurodegenerativas/induzido quimicamente , Doenças Neurodegenerativas/patologia , Pentilenotetrazol/efeitos adversos , Animais , Convulsivantes/farmacologia , Giro Denteado/fisiopatologia , Masculino , Doenças Neurodegenerativas/fisiopatologia , Neurônios/patologia , Pentilenotetrazol/farmacologia , Ratos , Ratos WistarRESUMO
The paper deals with a description of mental disorders seen in patients who had been operated for larynx cancer and who were subsequently subjected to radiotherapy. It is shown that there is a certain dependence of the structure of psychopathological changes on the doses and duration or radiation (prior to and following the operation). The author stresses the fact that radiotherapy is one of the significant factors creating a pathologically changed basis and provoking the appearance of mental disorders.
