1.
Angew Chem Int Ed Engl
; 56(33): 9719-9722, 2017 08 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28608622
RESUMO
Described herein is a novel concept for SN 2 reactions at tertiary carbon centers in epoxides without activation of the leaving group. Quantum chemical calculations show why SN 2 reactions at tertiary carbon centers are proceeding in these systems. The reaction allows flexible synthesis of 1,3-diol building blocks for natural product synthesis with excellent control of the relative and absolute configurations.