3-trifluoromethanesulfonamido-pyrrolidine: a general organocatalyst for anti-selective mannich reactions.

Mannich-type reactions of a glyoxylate imine with carbonyl compounds catalyzed by 3-trifluoromethanesulfonamidopyrrolidine proceed with high yields and anti-stereoselectivity. The catalyst is easily prepared and the transformation appears to be quite general accommodating aldehydes or ketones.